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Protein
Submitted name:

ephrin type-A receptor 3 isoform X3

Gene

epha3

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPUniRule annotation1
Active sitei746Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi627 – 635ATPUniRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ephrin type-A receptor 3 isoform X3Imported
Gene namesi
Name:epha3Imported
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
Proteomesi
  • UP000221080 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei542 – 564HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501303950020 – 956Sequence analysisAdd BLAST937

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 207Eph LBDInterPro annotationAdd BLAST179
Domaini325 – 435Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini436 – 531Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini621 – 882Protein kinaseInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd10481 EphR_LBD_A3, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034266 EphA3_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2D0R5Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCTRFLTLL LLLFMLVSCA EFIVYPSNEV NLLDSKASQG ELGWISYPPH
60 70 80 90 100
GWEEISGVDE HYTPIRTFQV CNVMEYSQNN WLRTNWIPRS SAQKIYVELK
110 120 130 140 150
FTLRDCNSIP LVLGTCKETF NLHYLETDED QGSKFREHQF SKIDTIAADE
160 170 180 190 200
SFTQMDLGDR ILKLNTEVRE VGPVTKKGFY LAFQDVGACV ALVSVRVYFK
210 220 230 240 250
KCPFTVRNLA SFPDTVPMDT QSLVEVRGSC VNNSKEEDPP KMYCSTEGEW
260 270 280 290 300
LVPIGKCLCN IGYEDRGVTC QACRPGFYKA SSGNMKCSKC PPHSYTHKEG
310 320 330 340 350
AVHCICDKNY FRADGDPVSM ACTRPPSAPR NVISVINETS VILDWSWPED
360 370 380 390 400
TGGRKDLIFK VVCKRCLAGS KQCEPCRGAV RFLPRASGLL NTTVTVADLL
410 420 430 440 450
AHTNYTFEIE AENGVSSLAP AMRQHASVTI TTNQAAPSQV TIIRKDRTSR
460 470 480 490 500
NSISLSWLEP ERPNGIILDY EVKYYEKQEQ ETSYTILRCK GTNVTLNGLK
510 520 530 540 550
PDTRYLLQIR ARTAAGYGSS SRKFEFETSP DSFSISSENS QVVLIAIASA
560 570 580 590 600
VAIILLTVVL YIVISRCCGY SKSKHPDKKR LHFGNGHLRL PGIRTYVDPH
610 620 630 640 650
TYEDPSQAVH EFAKELDASC IAIDKVVGAG EFGEVCSGRL KLPSKKEICV
660 670 680 690 700
AIKTLKAGYT ETQRRDFLSE ASIMGQFDHP NIIRLEGVVT RSKPVMIVTE
710 720 730 740 750
YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR
760 770 780 790 800
NILVNSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK
810 820 830 840 850
FTSASDVWSY GIVLWEVLSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP
860 870 880 890 900
APLYQLMLDC WQKDRNNRPK FEQIVSILDK LIRNPGSLKI TASTASRPVN
910 920 930 940 950
QLQTSTDITS FSTVGHWLES ARTLPCKEAF SGVSYSSCDT LPKTSADFPE

PSNPIA
Length:956
Mass (Da):106,897
Last modified:December 20, 2017 - v1
Checksum:i18543095E90B9D30
GO

Sequence databases

RefSeqiXP_017325937.1, XM_017470448.1
UniGeneiIpu.29825

Genome annotation databases

GeneIDi108266754

Similar proteinsi

Entry informationi

Entry nameiA0A2D0R5Q1_ICTPU
AccessioniPrimary (citable) accession number: A0A2D0R5Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: July 18, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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