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Entry version 14 (10 Feb 2021)
Sequence version 1 (20 Dec 2017)
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Protein
Submitted name:

coiled-coil domain-containing protein 180

Gene

ccdc180

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
coiled-coil domain-containing protein 180Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccdc180Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7998 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000221080 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 571DUF4455InterPro annotationAdd BLAST461
Domaini1144 – 1349DUF4456InterPro annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 62DisorderedSequence analysisAdd BLAST27
Regioni74 – 93DisorderedSequence analysisAdd BLAST20
Regioni1078 – 1102DisorderedSequence analysisAdd BLAST25
Regioni1353 – 1373DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili464 – 509Sequence analysisAdd BLAST46
Coiled coili616 – 636Sequence analysisAdd BLAST21
Coiled coili760 – 780Sequence analysisAdd BLAST21
Coiled coili862 – 882Sequence analysisAdd BLAST21
Coiled coili895 – 922Sequence analysisAdd BLAST28
Coiled coili1267 – 1287Sequence analysisAdd BLAST21
Coiled coili1420 – 1440Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 62PolarSequence analysisAdd BLAST20
Compositional biasi1353 – 1367PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNIKCQV

Database of Orthologous Groups

More...
OrthoDBi
47728at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026701, CCDC180
IPR028089, DUF4455
IPR027914, DUF4456

The PANTHER Classification System

More...
PANTHERi
PTHR21444:SF14, PTHR21444:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14643, DUF4455, 1 hit
PF14644, DUF4456, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2D0PN63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEIRVVPSG KIYRQMFDAQ AHLSLSLHER RRQRAAHAGC LSGDNTDTGS
60 70 80 90 100
HQHPLRSQTE QCSEDTMRNQ LFSGTKPALS VDQDDQEETT GLPDRVVSEK
110 120 130 140 150
SGSDIIERLM EKKQREHMEA VTQLQRDLIE LSAGYETLLK ETGEDFLLKL
160 170 180 190 200
SEYDEEVERL MHGDDLEALS FQDLHKIWTS VSHEFAMRRN CIQELDELLV
210 220 230 240 250
KYEIERAAMI AAVLRKYTMT LEKISYVMPG DVHRLINNEA MMMNQALLAN
260 270 280 290 300
RRALAKLRLN LMEKDLQKEV LYHMRWETKL QDWKKMKVVT AVSQFKDFMN
310 320 330 340 350
SPEIQNPKNV QDTFSTMRTK QKVYSEQRLK ILEQVRNMTP PNCSKSSTAE
360 370 380 390 400
WYSSLSSVNE QIDRMHTETL TKLHEYYENT WQDCSLEVER FKNELSTCGL
410 420 430 440 450
TSDEIQEIVN CEMVPLIGKC QTQEEERLAA MEKAREGLAK TAAFLSKSLF
460 470 480 490 500
EFARGAANVW EMHSAGLQRK EQQLQNYLEE VRKNYEEKNQ KKEARLDVMM
510 520 530 540 550
DKLRQESTEE ALQAALEQIL KFLEEIKEGY VNFYKEGVDT VERYPVMVLE
560 570 580 590 600
EIHAYSVAVS QYFSVKEIYS QDPEELQILY PSLTLRASRI KKSPPSVNLS
610 620 630 640 650
PNAFQNVTPQ AHTPDLSHAE ENIDYFSQEL RDSQSETFTT AKGNVYSCPV
660 670 680 690 700
IQCDDAEEHL KVMEVEAVLY PESLIVELQR DVREKFFNHL EERSQEVLNH
710 720 730 740 750
TVVIMDAKKE KLKSELDLRL HLHQPRAKRI EMDIHNVRAA ELILHEDRVD
760 770 780 790 800
RHCKGILQAL ADLRTDFDNL QETRRKLNEG FRAKIHSKED TLYTATKSYT
810 820 830 840 850
LVKLSASVQS SLAEHMNGIQ ELQRQFRQNV EIKFEGLREA NAQLMKHFKL
860 870 880 890 900
FVEGGNFTPK EIEKYRKHLE KVAKRIDSAD EALMLDMKGT ESKYLDQAKE
910 920 930 940 950
VISKFEEKLQ FLKVDLMFLE KIQSVLTNTQ VQIKAEAMKS NTHKKMISTV
960 970 980 990 1000
MSKLKDKLEA YTQCCPDNGV TSGDISGLTS TLIEELRKRS QYLDCYLDPS
1010 1020 1030 1040 1050
MAVPLPDAPL QGAFAVAARP RSRKQEQVGS PAADPLLQPS CMGGAFMEDK
1060 1070 1080 1090 1100
AVEVVRGLLR ISKSQTCQDA SVGLKEASSA TVTAPARTSS PPESVNSQSV
1110 1120 1130 1140 1150
RRLTKPTRFD KKFQVFGPKP DEQQEILTFK GLITNILWEA NDLLLQAAED
1160 1170 1180 1190 1200
FYKKKERRSV SRPQYIQESF ELCAEDLNKR LLVYQSQSHE YHRGCVQEFC
1210 1220 1230 1240 1250
KQLKTIEEIV CEIPEALLTK LRDQHLEDLS RSLTLVRQQF ERTWQQSEEK
1260 1270 1280 1290 1300
KREHRGKLCV RLNHPACEEE LNRLVAAEDD RQEEQRKATE NNRLELQACI
1310 1320 1330 1340 1350
KKNADAFVTA LATLTEHLLF QLDNIVTTDE IQGGSVEPKR ENITTLVRRT
1360 1370 1380 1390 1400
QAGTLQEERK ERPLSEKGSR AWPGVSYFGT TDGSSVKQQK RETATITTAK
1410 1420 1430 1440 1450
TTRAQLKVME VRNALHQSYE QKIMEELESL EISRQEQEAE LFHWKEHWRN
1460
ELKILSTLKS E
Length:1,461
Mass (Da):168,533
Last modified:December 20, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1351C25BFDF6337B
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_017307454.1, XM_017451965.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108255767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ipu:108255767

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_017307454.1, XM_017451965.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi108255767
KEGGiipu:108255767

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100499483

Phylogenomic databases

OMAiVNIKCQV
OrthoDBi47728at2759

Family and domain databases

InterProiView protein in InterPro
IPR026701, CCDC180
IPR028089, DUF4455
IPR027914, DUF4456
PANTHERiPTHR21444:SF14, PTHR21444:SF14, 1 hit
PfamiView protein in Pfam
PF14643, DUF4455, 1 hit
PF14644, DUF4456, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2D0PN63_ICTPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2D0PN63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 10, 2021
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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