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UniProtKB - A0A2C9KXQ8 (A0A2C9KXQ8_BIOGL)

Entry version 13 (10 Feb 2021)
Sequence version 1 (20 Dec 2017)
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Protein

LisH domain-containing protein

Gene

106068128

Organism
Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LisH domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:106068128Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6526 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Hygrophila › Lymnaeoidea › Planorbidae › Biomphalaria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000076420 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:BGLB024659

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 96LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni587 – 609DisorderedSequence analysisAdd BLAST23
Regioni680 – 729DisorderedSequence analysisAdd BLAST50
Regioni879 – 912DisorderedSequence analysisAdd BLAST34
Regioni925 – 975DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili229 – 278Sequence analysisAdd BLAST50
Coiled coili283 – 303Sequence analysisAdd BLAST21
Coiled coili372 – 406Sequence analysisAdd BLAST35
Coiled coili434 – 454Sequence analysisAdd BLAST21
Coiled coili512 – 549Sequence analysisAdd BLAST38
Coiled coili644 – 664Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi688 – 717PolarSequence analysisAdd BLAST30
Compositional biasi926 – 944PolyampholyteSequence analysisAdd BLAST19
Compositional biasi945 – 959PolarSequence analysisAdd BLAST15
Compositional biasi960 – 975PolyampholyteSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006594, LisH

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16045, LisH_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2C9KXQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDHPEYLSA EELRNRLYHS LRNRGFVDSI KSQLRNSLVT ELQQTVHGPL 
        60         70         80         90        100
TLKDLNIPEE GSLLHRASNS LVANHLSACQ YEYTLSVFLP ESGLSQDKKF 
       110        120        130        140        150
EALDLLKLLN ISPLSRLYQR LIAETHKDSK RGFLWQGVSE VSSLHANSIN 
       160        170        180        190        200
TVGCQTDLIK VGPITPLDEK LSDVDEMYAS RREDYLRTGR AGAEERLLSF 
       210        220        230        240        250
QRQLEDRYNT QLKMELARMK ESEIATIKLS EKENSRKTLE QAKRDMERIY 
       260        270        280        290        300
KDRYDALVIR ERNTMERLQQ QTEMQEREIY AQRQSILEEI EAVRQREVEV 
       310        320        330        340        350
KREAEVNKRE KRLSEERVKD KETELRRREM EIKQRESSFE QRLQNEMAQF 
       360        370        380        390        400
KLDQQARFIE RVQNVEVREQ TLKEQERILS EEKFRLQQIK DELRDKTQRV 
       410        420        430        440        450
NELETKLSEC KYSEVNANKN NEYLNAKLRD MSDYSTLKEQ VVLYRNELET 
       460        470        480        490        500
LRTRLAEVLS MNERERGRQE ELLRELRRPS PESLMLQRDL ERAKESLRQE 
       510        520        530        540        550
QIVFNQQKQV LEARLKEELD CNKDLMARFE EQTLQMKEMN REIVDLRQHL 
       560        570        580        590        600
HMTTKALNNE VYRKAKEGLE QSQLVESRLS HKVHDSSRHS VDLNFDDHEP 
       610        620        630        640        650
QRPSRFDADP KEIYHGVDFE TFSQVRDGLY FEDDISSIDS ADVIAQAKYR 
       660        670        680        690        700
LKSLDQEAHN LEKAYHDFHC RITNIHAIPL DQPAQSPPRS RVVGQQQGAI 
       710        720        730        740        750
VTSPAQSPIP FDNPRSSTPY KQKRKPQEID DSFSELKTKP KLTADSQHPT 
       760        770        780        790        800
LTSKITLDID KGFVQNKHIT VADLEQRPGS PPLMVIAGSV SSDEGLPKGT 
       810        820        830        840        850
TLSALDQLEH HVTKTPAFTS AEQLEQVAKT SLVTVTHTES TSTRLMQPEL 
       860        870        880        890        900
VQPISLDTAW KSHAEDDVLD VKRRQRELQE EEEEMERERQ KLEEEQAREA 
       910        920        930        940        950
VSTVTNKLDE EDNIDPVMKQ YMAMVTQQKE KEKELAKKAV ASWQQEEKTE 
       960        970 
SQNASEELSA ATDDKSEHDD DMSSW
Length:975
Mass (Da):113,710
Last modified:December 20, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD61509EADBBD5E7A
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_013082892.1, XM_013227438.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		BGLB024659-RA; BGLB024659-PA; BGLB024659

Database of genes from NCBI RefSeq genomes

More...GeneIDi		106068128

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013082892.1, XM_013227438.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiBGLB024659-RA; BGLB024659-PA; BGLB024659
GeneIDi106068128

Organism-specific databases

VEuPathDBiVectorBase:BGLB024659

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
PfamiView protein in Pfam
PF16045, LisH_2, 1 hit
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2C9KXQ8_BIOGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2C9KXQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 10, 2021
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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