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Entry version 19 (12 Aug 2020)
Sequence version 1 (20 Dec 2017)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Gene

106058385

Organism
Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei327UniRule annotation1
Active sitei374UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationARBA annotation, TransducerUniRule annotationARBA annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesteraseUniRule annotation (EC:3.1.4.11UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:106058385Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6526 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataHygrophilaLymnaeoideaPlanorbidaeBiomphalaria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000076420 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini626 – 742PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini749 – 847C2InterPro annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni498 – 573DisorderedSequence analysisAdd BLAST76
Regioni934 – 961DisorderedSequence analysisAdd BLAST28
Regioni1027 – 1052DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili987 – 1007Sequence analysisAdd BLAST21
Coiled coili1096 – 1138Sequence analysisAdd BLAST43
Coiled coili1149 – 1169Sequence analysisAdd BLAST21
Coiled coili1197 – 1217Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi530 – 569PolarSequence analysisAdd BLAST40
Compositional biasi934 – 957PolarSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13361, PH_PLC_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR042531, PLC-beta_C_sf
IPR009535, PLC-beta_CS
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336, PTHR10336, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF06631, DUF1154, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000956, PLC-beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2C9KAI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKPFEFNWR IPVPEVLQIG CVFDIWDEEY SVYESNCMVK VDEYGFFICW
60 70 80 90 100
KSEGREGQVL ECSQVNDIRL GLAPKVSDTK VLADILEKSP HSLDSRTVTV
110 120 130 140 150
CSGLDLVNIT YTLLIARDPD VAKVWFEGLR KITLNTKANN VCPMTQLKKH
160 170 180 190 200
WIKLCCMVNP SGKIPVRGIT RTFASGKTEK MVMSSLKDLG LPSGKGDEID
210 220 230 240 250
PGLFTFDKFY ELYHMICPRS DIEDLFKSLS QNRSYLDIPQ LIEFFNDRQR
260 270 280 290 300
DPRLNEILFP FYNHFRVKNI IQSYETDADY LSKDWLSLDG FCRYLMSDEN
310 320 330 340 350
APVFLDRLDI YMDMDQPLAH YIINSSHNTY LTGRQFGGRS SVEMYRQVLL
360 370 380 390 400
AGCRCVELDC WDGRNEDQEP IITHGKAMCT DILFKDVIQA IKETAFVTSC
410 420 430 440 450
YPVILSFENH CSKLQQYKMA KYCEDLLGDF LLKKPIEGHP LEPGVPLPSP
460 470 480 490 500
NQLKFKILIK NKRLKPEVEK QQLEMFQKGM IQIVNEDSEV IEDPNVVATV
510 520 530 540 550
DGEDGPLNDD DADSASSIDS SPPPPPQVTT ATASTSTKTS DLVPTTKNTD
560 570 580 590 600
TEAHPELAKT NTGSVDSDSE LKKTSVKIPL SKKAKEELDD LLKTDSMDTA
610 620 630 640 650
LTADEEAALM SSYHYTGATT NIHPYLSAMV NYAQPVKFQG FDVAEAKNLH
660 670 680 690 700
FHMSSFSENT MYQMIKHRCI DILDYNKRQM SRIYPRGGRV DSSNFLPQIF
710 720 730 740 750
WNAGCQMVAL NFQTADINMQ LNQGKFEYNS NCGYLLKPDF MRRPDRTFDP
760 770 780 790 800
FSESPVDGVI AAHCSVQVIS GQFLSDKKVG TYVEVDMYGL PTDTIRREFR
810 820 830 840 850
TRVVPNNGLN PIYNEEPFVF RKVVLPELAV LRIAVFEDTG KLIGQRILPL
860 870 880 890 900
DGLQAGYRHI SLRTEGNFPL SLPTVFCRII LKTYVPVEFG DFVDALSAPI
910 920 930 940 950
LAMSQAEKRE KAMKDMGIDE RDISDVPVVR PTKINRPQNG QMSNSPNRMS
960 970 980 990 1000
QPNLNSVTGK KDDRRVPEEM IFEAITREKL TSEKIYFKLL RKQAKDLEML
1010 1020 1030 1040 1050
KRRHQKERSM MQRAHCTVVD KLVATHDKEK SATEKSMEKK MKKNKDSSSD
1060 1070 1080 1090 1100
LKTHEGKVLN LVSDHKLKIN ELVVQQTKEW SDMVVRQMTE EHELWKEHIV
1110 1120 1130 1140 1150
QQNESLAKLL EDAQKEQMAE LEAKQERENK ELKANQAKHS MDSTKTVLND
1160 1170 1180 1190 1200
KSIKNKAERE RRIRELNENN TKKFIEERKR FAVKHNRQQE ALKKVHLEQT
1210 1220 1230
EKMLAENQKA IEMIEMAYEE AKMATKPETD V
Length:1,231
Mass (Da):140,934
Last modified:December 20, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB06EB3C6DC29F4B
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_013071366.1, XM_013215912.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
BGLB016942-RE; BGLB016942-PE; BGLB016942

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
106058385

Bioinformatics Resource for Invertebrate Vectors of Human Pathogens

More...
VectorBasei
BGLB016942-RE; BGLB016942-PE; BGLB016942

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_013071366.1, XM_013215912.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiBGLB016942-RE; BGLB016942-PE; BGLB016942
GeneIDi106058385
VectorBaseiBGLB016942-RE; BGLB016942-PE; BGLB016942

Phylogenomic databases

OrthoDBi368239at2759

Family and domain databases

CDDicd13361, PH_PLC_beta, 1 hit
Gene3Di1.20.1230.10, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR016280, PLC-beta
IPR042531, PLC-beta_C_sf
IPR009535, PLC-beta_CS
IPR037862, PLC-beta_PH
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336, PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF06631, DUF1154, 1 hit
PF09279, EF-hand_like, 1 hit
PF17787, PH_14, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PIRSFiPIRSF000956, PLC-beta, 1 hit
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2C9KAI9_BIOGL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2C9KAI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: August 12, 2020
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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