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Entry version 17 (12 Aug 2020)
Sequence version 1 (20 Dec 2017)
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Protein
Submitted name:

Protein furry homolog-like

Gene

FRYL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein furry homolog-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRYLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29127, FRYL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000075539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A2C9F2R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A2C9F2R7, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 119MOR2-PAG1_midInterPro annotationAdd BLAST47
Domaini302 – 361MOR2-PAG1_midInterPro annotationAdd BLAST60
Domaini448 – 568MOR2-PAG1_midInterPro annotationAdd BLAST121
Domaini710 – 962MOR2-PAG1_CInterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 209DisorderedSequence analysisAdd BLAST25
Regioni1166 – 1201DisorderedSequence analysisAdd BLAST36
Regioni1214 – 1278DisorderedSequence analysisAdd BLAST65
Regioni1345 – 1371DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1568 – 1602Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 201PolarSequence analysisAdd BLAST17
Compositional biasi1169 – 1193PolarSequence analysisAdd BLAST25
Compositional biasi1236 – 1273PolarSequence analysisAdd BLAST38
Compositional biasi1345 – 1364AcidicSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086058

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid

The PANTHER Classification System

More...
PANTHERi
PTHR12295, PTHR12295, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A2C9F2R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XRIQTAHPAG RQVMLHYLLP WMNNIELVDL KPLPTARRHD EDEDDSLKDR
60 70 80 90 100
ELMVTSRRWL RGEGWGSPQA TAMVLNNLMY MTAKYGDELA WSEVENVWTT
110 120 130 140 150
LADGWPKNLK IILHFLISIC GVNSEPSLLP YVKKVIVYLG RDKTMQLLEE
160 170 180 190 200
LVSELQLTDP VSSGVTHMDN PPYYRITSSY KIPSVTSGTT SSSNTMVAPT
210 220 230 240 250
DGNPDNKPIK ENIEESYVHL DIYSGLNSHL NRQHHRLESR YSSSSGGSYE
260 270 280 290 300
EEKSDSMPLY SNWRLKVMEH NQGEPLPFPP AGGCWSPLVD YVPETSSPGL
310 320 330 340 350
PLHRCNIAVI LLTDLIIDHS VKVEWGSYLH LLLHAIFIGF DHCHPEVYEH
360 370 380 390 400
CKRLLLHLLI VMGPNSNIRT VASVLLRNKE FNEPRVLTVK QVAHLDYNFT
410 420 430 440 450
AGINDFIPDY QPSPMTDSGL SSSSTSSSIS LGNNSAAISH LHTTILNEVD
460 470 480 490 500
ISVEQDGKVK TLMEFITSRK RGPLWNHEDV SAKNPSIKSA EQLTTFLKHV
510 520 530 540 550
VSVFKQSSSE GIHLEHHLSE VALQTALSCS SRHYAGRSFQ IFRALKQPLT
560 570 580 590 600
ATTLSDVLSR LVETVGDPGE DAQGFVIELL LTLESAIDTL AETMKHYDLL
610 620 630 640 650
SALSQTSYHD PIMGNKYAAN RKSTGQLNLS TSPINSSSYL GYNSNARSNS
660 670 680 690 700
LRLSLIGDRR GDRRRSNTLD IMDGRINHSS SLARTRSLSS LREKGMYDVQ
710 720 730 740 750
STTEPTNLMA TIFWIAASLL ESDYEYEYLL ALRLLNKLLI HLPLDKSESR
760 770 780 790 800
EKIENVQSKL KWTNFPGLQQ LFLKGFTSAS TQEMTVHLLS KLISVSKHTL
810 820 830 840 850
VDPSQLSGFP LNILCLLPHL IQHFDSPTQF CKETASRIAK VCAEEKCPTL
860 870 880 890 900
VNLAHMMSLY STHTYSRDCS NWINVVCRYL HDSFSDTTFN LVTYLAELLE
910 920 930 940 950
KGLSSMQQSL LQIIYSLLSH IDLSAAPAKQ FNLEIIKIIG KYVQSPYWKE
960 970 980 990 1000
ALNILKLVVS RSASLVVPSD IPKTYGGDTG SPEISFTKIF NNVSKELPGK
1010 1020 1030 1040 1050
TLDFHFDISE TPIIGNKYGD QHSAAGRNGK PKVIAVTRST SSTSSGSNSN
1060 1070 1080 1090 1100
ALVPVSWKRP QLSQRRTREK LMNVLSLCGP ESGLPKNPSV VFSSNEDLEV
1110 1120 1130 1140 1150
GDQQTSLIST TEDINQEEEV AVEDNSSEQQ FGVFKDFDFL DVELEDAEGE
1160 1170 1180 1190 1200
SMDNFNWGVR RRSLDSIDKG DTPSLQEYQC SSSTPSLNLT NQEDTDESSE
1210 1220 1230 1240 1250
EEAALTASQI LSRTQMLNSD SATDETIPDH PDLLLQSEDS TGSITTEEVL
1260 1270 1280 1290 1300
QIRDETPTLE ASLDNANSRL PEDTTSVLKE EHVTTFEDEG SYIIQEQQES
1310 1320 1330 1340 1350
LVCQGILDLE ETEMPEPLAP ESYPESVCEE DVTLALKELD ERCEEEEADF
1360 1370 1380 1390 1400
SGLSSQDEEE QDGFPEVQTS PLPSPFLSAI IAAFQPVAYD DEEEAWRCHV
1410 1420 1430 1440 1450
NQMLSDTDGS SAVFTFHVFS RLFQTIQRKF GEITNEAVSF LGDSLQRIGT
1460 1470 1480 1490 1500
KFKSSLEVMM LCSECPTVFV DAETLMSCGL LETLKFGVLE LQEHLDTYNV
1510 1520 1530 1540 1550
KREAAEQWLD DCKRTFGAKE DMYRINTDAQ ELELCRRLYK LHFQLLLLFQ
1560 1570 1580 1590 1600
AYCKLINQVN TIKNEAEVIN MSEELAQLES ILKEAESASE NEEIDISKAA
1610 1620 1630 1640 1650
QTTIETAIHS LIETLKNKEF ISAVAQVKAF RSLWPSDIFG SCEDDPVQTL
1660 1670 1680 1690 1700
LHIYFHHQTL GQTGSFAVIG SNLDMSEANY KLMELNLEIR ESLRMVQSYQ
1710
LLAQAKPMGN MVSTGF
Length:1,716
Mass (Da):192,214
Last modified:December 20, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF87E61835C6EE75B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O94915FRYL_HUMAN
Protein furry homolog-like
FRYL AF4P12, KIAA0826
3,013Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2S2F2Z2S2_HUMAN
Protein furry homolog-like
FRYL
1,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEZ9A0A286YEZ9_HUMAN
Protein furry homolog-like
FRYL
1,563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9X0H0Y9X0_HUMAN
Protein furry homolog-like
FRYL
1,455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6E1XQM6A0A6E1XQM6_HUMAN
Protein furry homolog-like
FRYL
1,233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB90A0A669KB90_HUMAN
Protein furry homolog-like
FRYL
964Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9B9D6R9B9_HUMAN
Protein furry homolog-like
FRYL
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000507873; ENSP00000422408; ENSG00000075539

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PeptideAtlasiA0A2C9F2R7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23821, 27 antibodies

Genome annotation databases

EnsembliENST00000507873; ENSP00000422408; ENSG00000075539

Organism-specific databases

HGNCiHGNC:29127, FRYL
OpenTargetsiENSG00000075539

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00610000086058

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRYL, human

Gene expression databases

ExpressionAtlasiA0A2C9F2R7, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid
PANTHERiPTHR12295, PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 3 hits
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2C9F2R7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2C9F2R7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: August 12, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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