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Protein

Pyruvate kinase

Gene

pykA1

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA1), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno), Enolase (eno)
  5. Pyruvate kinase (pyk), Pyruvate kinase (COK92_16395), Pyruvate kinase (pykA1), Pyruvate kinase (A9486_15570), Pyruvate kinase (pyk), Pyruvate kinase (pyk), Pyruvate kinase (MCCC1A01412_07425), Pyruvate kinase (pyk), Pyruvate kinase (pyk), Pyruvate kinase (CN488_18960), Pyruvate kinase (pyk), Pyruvate kinase (CN272_12880), Pyruvate kinase (BVG01_09765), Pyruvate kinase (pyk2), Pyruvate kinase (CN286_13255), Pyruvate kinase (COE56_07990), Pyruvate kinase (CON16_24335), Pyruvate kinase (COJ30_11890), Pyruvate kinase (CN907_26205), Pyruvate kinase (A9486_00415), Pyruvate kinase (CN504_15055), Pyruvate kinase (pyk), Pyruvate kinase (ABW01_15615)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykA1Imported
Ordered Locus Names:BA_3382Imported, GBAA_3382Imported
ORF Names:COL95_10655Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome
  • UP000224851 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi260799.BAS3136

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 330PKInterPro annotationAdd BLAST325

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0469 LUCA
HOGENOMiHOG000021558
KOiK00873

Family and domain databases

Gene3Di2.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2B6C9J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIDRVCTIG PASNNKETLA KLINNGMKIV RLNLSHGTHE SHKDIIRLVK
60 70 80 90 100
SLDDSIKILG DVQGPKIRLG EIKGEQITLQ AGDSFMLRTQ PVTGSSTEAS
110 120 130 140 150
VDYEGIANDV KVGSRILMND GEVELIVEKV STDKIETKVK TGGNISSHKG
160 170 180 190 200
VNLPGAIVSL PAITEKDKKD IQFLLEEDVD FIACSFVRKP SHIKEIRDFI
210 220 230 240 250
QQYKETSPNL IAKIETMEAI ENFQDICKEA DGIMIARGDL GVELPYQFIP
260 270 280 290 300
LLQKMMIQEC NRTNTYVITA TQMLQSMVDH SIPTRAEVTD VFQAVLDGTN
310 320 330 340 350
AVMLSAESAS GEHPVESVST LRLVSEFAEH VKKDGPFVMK DVLELLHKSL

DE
Length:352
Mass (Da):38,860
Last modified:February 28, 2018 - v1
Checksum:i94A73CAB2AB03E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27154.1
AE017334 Genomic DNA Translation: AAT32490.1
NVHS01000027 Genomic DNA Translation: PGB54187.1
RefSeqiNP_845668.1, NC_003997.3
WP_000151131.1, NZ_QPKQ01000003.1

Genome annotation databases

EnsemblBacteriaiAAT32490; AAT32490; GBAA_3382
ANH89653; ANH89653; A8C77_16475
GeneIDi1084882
KEGGiban:BA_3382
banh:HYU01_16590
bar:GBAA_3382
PATRICifig|1392.230.peg.3332

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27154.1
AE017334 Genomic DNA Translation: AAT32490.1
NVHS01000027 Genomic DNA Translation: PGB54187.1
RefSeqiNP_845668.1, NC_003997.3
WP_000151131.1, NZ_QPKQ01000003.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi260799.BAS3136

Protocols and materials databases

DNASUi1084882
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT32490; AAT32490; GBAA_3382
ANH89653; ANH89653; A8C77_16475
GeneIDi1084882
KEGGiban:BA_3382
banh:HYU01_16590
bar:GBAA_3382
PATRICifig|1392.230.peg.3332

Phylogenomic databases

eggNOGiCOG0469 LUCA
HOGENOMiHOG000021558
KOiK00873

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00188

Family and domain databases

Gene3Di2.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2B6C9J6_BACAN
AccessioniPrimary (citable) accession number: A0A2B6C9J6
Secondary accession number(s): E9QRA9
, E9QRB0, Q6HW95, Q6KQE6, Q81N35
Entry historyiIntegrated into UniProtKB/TrEMBL: February 28, 2018
Last sequence update: February 28, 2018
Last modified: November 7, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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