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Protein

Octanoyl-[GcvH]:protein N-octanoyltransferase

Gene

lipL

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.UniRule annotation

Miscellaneous

The reaction proceeds via a thioester-linked acyl-enzyme intermediate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

[Glycine cleavage system H]-N6-octanoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-octanoyl-L-lysine.UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei161Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyl-[GcvH]:protein N-octanoyltransferaseUniRule annotation (EC:2.3.1.204UniRule annotation)
Alternative name(s):
Octanoyl-[GcvH]:E2 amidotransferaseUniRule annotation
Gene namesi
Name:lipLUniRule annotation
ORF Names:CN488_05985Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000219880 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 229BPL/LPL catalyticInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the octanoyltransferase LipL family.UniRule annotation

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2A8KYD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNSRSILSQ PEWRIVDQSS LGPTFHALQS FAMDDTLCTS IGNGRSAATM
60 70 80 90 100
RSWVHHNTIV LGIQDSRLPH LEEGISFLKE NNFNVIVRNS GGLAVVLDEG
110 120 130 140 150
VLNVSLLFQE TEKGIDIDLG YDTMWHLIQE MLKDYDVTIE AKEIIGSYCP
160 170 180 190 200
GSYDLSIRDQ KFAGISQRRI RGGVAVQIYL CATGSGSERA ALVRDFYNLA
210 220 230 240 250
IQGEETRFTY PEIVPSTMAS LSELLGETIT VQDLMMRLLK TLQQFAPKLT
260 270 280
PSQLTIDEIP LYETNLQRII DRNNKALGLE K
Length:281
Mass (Da):31,418
Last modified:December 20, 2017 - v1
Checksum:i9297FBB19F17EE91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NTYQ01000007 Genomic DNA Translation: PES24901.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NTYQ01000007 Genomic DNA Translation: PES24901.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_02119 LipL, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024897 LipL
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2A8KYD5_BACAN
AccessioniPrimary (citable) accession number: A0A2A8KYD5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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