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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Yersinia pseudotuberculosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Biosynthetic arginine decarboxylase (speA), Biosynthetic arginine decarboxylase (speA), Biosynthetic arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPolyamine biosynthesisUniRule annotationSAAS annotation, Putrescine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00186;UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
ORF Names:CRM78_11500Imported
OrganismiYersinia pseudotuberculosisImported
Taxonomic identifieri633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000219975 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

SMRiA0A2A7VJ04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 368Orn_Arg_deC_NInterPro annotationAdd BLAST268

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 318Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01585

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2A7VJ04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDNLISRP LTAGAHVSLR SMQEVAMNDR NASKMLSTYN VAYWGGNYYD
60 70 80 90 100
VNELGHISVC PDPDIREARV DLAQLVKKMQ LEQGQRLPAL FCFPQILQHR
110 120 130 140 150
LRSINAAFKR ARESFGYEGG YFLVYPIKVN QHRRVIESLV NSGEPLGLEA
160 170 180 190 200
GSKAEMMAVL AHAGMTRSVI VCNGYKDREY IRLALIGEKL GHKVYLVIEK
210 220 230 240 250
MSEIKMVLEE AERLNVVPRL GVRARLASQG SGKWQASGGE KSKFGLSATQ
260 270 280 290 300
VLQLVDMLRE ANSLESLQLL HFHLGSQLSN IRDISTGVRE SARFYVELHK
310 320 330 340 350
LGVNIQCFDV GGGLGVDYEG TRSQSDCSVN YGLNEYANNV IWGIGDACNE
360 370 380 390 400
HGLPHPTVIT ESGRAVTAHH TVLVSNVIGV ERNEFCEPQP PEAGAPRALE
410 420 430 440 450
SLWDTWQEMQ EPENRRSLRE WLHDSQMDLH DVHTQYAHGM LDLTHRAWAE
460 470 480 490 500
QLYLSICNEI QKQLDPSNRA HRPIIDELQE RMADKLYVNF SLFQSMPDAW
510 520 530 540 550
GIDQLFPVLP LEGLDKPPER RAVLLDITCD SDGTIDHYID GDGVATTMPM
560 570 580 590 600
PPYDPENPPL LGFFMVGAYQ EILGNMHNLF GDTAAVDVYV FPDGTVEVEQ
610 620 630 640 650
TDEGDTVADM LEYVQLNPEK LLEHFRGQVK ETDLDTELQA QFLEEFEAGL

YGYTYLEDE
Length:659
Mass (Da):74,104
Last modified:December 20, 2017 - v1
Checksum:iAD2795F60745B686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDEJ01000002 Genomic DNA Translation: PEI13817.1
RefSeqiWP_002209969.1, NZ_UHJE01000003.1

Genome annotation databases

KEGGiypc:BZ23_2766
ypq:DJ40_3310
ypr:BZ20_2995
ypu:BZ21_2486

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDEJ01000002 Genomic DNA Translation: PEI13817.1
RefSeqiWP_002209969.1, NZ_UHJE01000003.1

3D structure databases

SMRiA0A2A7VJ04
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiypc:BZ23_2766
ypq:DJ40_3310
ypr:BZ20_2995
ypu:BZ21_2486

Phylogenomic databases

KOiK01585

Enzyme and pathway databases

UniPathwayi
UPA00186;UER00284

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2A7VJ04_YERPU
AccessioniPrimary (citable) accession number: A0A2A7VJ04
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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