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Protein

Cardiolipin synthase A

Gene

cls

Organism
Edwardsiella tarda
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotationSAAS annotation, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotationSAAS annotation (EC:2.7.8.-UniRule annotationSAAS annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsImported
Synonyms:clsAUniRule annotation
ORF Names:CRM76_13850Imported
OrganismiEdwardsiella tardaImported
Taxonomic identifieri636 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000219788 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalUniRule annotationAdd BLAST20
Transmembranei37 – 58HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesteraseInterPro annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesteraseInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

A0A2A7U3S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTFYTVISW LAIFGYWLLI ASVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSFGE LHLGKRRAER ARAMWPSTAR WLADLRNCRS IFATHNSEVA
110 120 130 140 150
APLFQLCERR QGIAGVKGNQ LQLLTSSDET LKALIRDIEL AHNSIEMVFY
160 170 180 190 200
IWQPGGLADQ VAEALMAAAR RGVHCRLMLD SAGSVAFFRS PYPAMMREAG
210 220 230 240 250
IEVVEALQVN LLRVFLRRMD LRQHRKVVLV DNFIAYTGSM NLVDPRYFKQ
260 270 280 290 300
DAGVGQWVDV MARMEGPVAT TMGIYYAFDW EMETGKRILP PEPTCNILPF
310 320 330 340 350
EKESGHTIQV IASGPGFPEE LIHQSLLTAV YSARQQLVMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIIVPK KNDSMMVGWA SRAFFTEMLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDD GFGSDLACVQ
460 470 480
DDYIARSTLL DPLTWLKRPL WQRMVERLFY FFSPLL
Length:486
Mass (Da):54,843
Last modified:December 20, 2017 - v1
Checksum:i25135FFDF1C3EA84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDDV01000013 Genomic DNA Translation: PEH72944.1
RefSeqiWP_005285197.1, NZ_UFYK01000001.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDDV01000013 Genomic DNA Translation: PEH72944.1
RefSeqiWP_005285197.1, NZ_UFYK01000001.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2A7U3S0_EDWTA
AccessioniPrimary (citable) accession number: A0A2A7U3S0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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