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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Edwardsiella tarda
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi3Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi11Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi14Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi87Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei212S-adenosyl-L-methionineUniRule annotation1
Binding sitei241S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei262S-adenosyl-L-methionineUniRule annotation1
Binding sitei307S-adenosyl-L-methionineUniRule annotation1
Active sitei334PROSITE-ProRule annotation1
Active sitei334NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processrRNA processingUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotationSAAS annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
ORF Names:CRM76_10255Imported
OrganismiEdwardsiella tardaImported
Taxonomic identifieri636 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesHafniaceaeEdwardsiella
Proteomesi
  • UP000219788 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2A7U1V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHCAQYQAGR CHSCQWLSLP YSRQLDDKQH HLAALLDDQP VGEWLPACPS
60 70 80 90 100
AEQAMRNKAK MVVTGSVERP LLGMLTREGE GVDLCDCPLY PASFAPVFAV
110 120 130 140 150
LKAFIPRAGL TPYNVARRRG ELKYLLLTES RLNGEMMLRF VLRSENKLAQ
160 170 180 190 200
LRQALPWLQA QLPQLAVISV NLQPVPMAIL EGEQEIFLSE QQALEESFNG
210 220 230 240 250
VPLYIRPQSF FQTNPAVAEA LYAEARDWVR ALGVTAMWDL FCGVGGFGLH
260 270 280 290 300
CATPEMALTG IEISAEAIAC ARRSAARLGL EKVSFAALDS TAFADEHGQA
310 320 330 340 350
PQLVLVNPPR RGIGVALCDD LRRMAPPYIL YSSCNAQSMA QDIACLESYR
360 370
IAKIRLFDMF PHTAHYEVLT LLVHQRVQA
Length:379
Mass (Da):42,052
Last modified:December 20, 2017 - v1
Checksum:i07198B654F91A89F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDDV01000013 Genomic DNA Translation: PEH72277.1
RefSeqiWP_035598132.1, NZ_UFYK01000001.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
PDDV01000013 Genomic DNA Translation: PEH72277.1
RefSeqiWP_035598132.1, NZ_UFYK01000001.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2A7U1V3_EDWTA
AccessioniPrimary (citable) accession number: A0A2A7U1V3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: November 7, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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