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Protein

Quinolinate synthase

Gene

BB463_00520

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.SAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H2O + phosphate.SAAS annotation

Cofactori

[4Fe-4S] clusterSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from iminoaspartate.SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Quinolinate synthase (BB398_07655), Quinolinate synthase (BB404_07050), Quinolinate synthase (BB423_05755), Quinolinate synthase (AK968_04145), Quinolinate synthase (BGL78_02880), Quinolinate synthase (HPF17_0045), Quinolinate synthase (BZK18_04270), Quinolinate synthase (BZK19_04595), Quinolinate synthase (HPF94_0043), Quinolinate synthase (C2R76_05535), Quinolinate synthase A (nadA), Quinolinate synthase (BB401_04235), Quinolinate synthase (BGL60_02890), Quinolinate synthase (BB468_06445), Quinolinate synthase A (nadA), Quinolinate synthase (BB448_06675), Quinolinate synthase (C2S37_01960), Quinolinate synthase (BB454_05770), Quinolinate synthase (ACM23_00975), Quinolinate synthase (AEY53_04695), Quinolinate synthase (HPF72_0043), Quinolinate synthase A (nadA), Quinolinate synthase (BB415_07315), Quinolinate synthase (ACM31_06075), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2R84_03715), Quinolinate synthase (HPY499_01385), Quinolinate synthase (C2R61_01325), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2R56_07420), Quinolinate synthase (C2R64_01230), Quinolinate synthase (BB458_04130), Quinolinate synthase (BB399_06925), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BGL83_04195), Quinolinate synthase (BB482_06490), Quinolinate synthase (C2R66_07335), Quinolinate synthase (C2R52_07065), Quinolinate synthase (HPY228_06205), Quinolinate synthase (C2S43_00550), Quinolinate synthase (HPF38_0050), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (CEP78_008860), Quinolinate synthase (C2R86_04970), Quinolinate synthase (BB413_07120), Quinolinate synthase (C2R74_04685), Quinolinate synthase (C2R45_07955), Quinolinate synthase (C2R81_07605), Quinolinate synthase A (nadA), Quinolinate synthase (BGL55_07905), Quinolinate synthase (AC783_03365), Quinolinate synthase A (nadA), Quinolinate synthase (BB451_03970), Quinolinate synthase A (nadA), Quinolinate synthase (C2R54_02845), Quinolinate synthase (C2S45_05075), Quinolinate synthase (BB475_02850), Quinolinate synthase (HPY1786_06525), Quinolinate synthase (BB445_06880), Quinolinate synthase (BB403_04690), Quinolinate synthase (BB425_05080), Quinolinate synthase (BB389_07500), Quinolinate synthase (BB464_04980), Quinolinate synthase (C2R46_05590), Quinolinate synthase (BGL67_05465), Quinolinate synthase A (nadA), Quinolinate synthase (C2R47_04725), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AA973_06160), Quinolinate synthase (ACM37_05900), Quinolinate synthase (ACM25_04670), Quinolinate synthase A (nadA), Quinolinate synthase (HPMKF10_0090), Quinolinate synthase (C2R94_06780), Quinolinate synthase (C2S01_06240), Quinolinate synthase (BGL75_01500), Quinolinate synthase (BB449_05335), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BGL71_06650), Quinolinate synthase (C2R87_02090), Quinolinate synthase (AOD77_0202490), Quinolinate synthase (nadA), Quinolinate synthase (AM496_03720), Quinolinate synthase (BB483_07670), Quinolinate synthase (C2R71_05645), Quinolinate synthase (HPY655_06365), Quinolinate synthase (BGL77_00455), Quinolinate synthase (BB471_07420), Quinolinate synthase A (nadA), Quinolinate synthase (AA976_06880), Quinolinate synthase (BZK20_00770), Quinolinate synthase (ACM26_07720), Quinolinate synthase A (nadA), Quinolinate synthase (C2R68_06705), Quinolinate synthase (BB408_07620), Quinolinate synthase (BB433_07695), Quinolinate synthase (HPF78_0049), Quinolinate synthase (BHU51_02520), Quinolinate synthase A (nadA), Quinolinate synthase (AC786_05590), Quinolinate synthase (BB386_06910), Quinolinate synthase A (nadA), Quinolinate synthase (HPMKF3_0043), Quinolinate synthase (C2R77_03215), Quinolinate synthase (C2R91_00315), Quinolinate synthase (BZK27_01705), Quinolinate synthase (BGL73_04555), Quinolinate synthase (BB430_03035), Quinolinate synthase (BGL74_00845), Quinolinate synthase (HPF51_0044), Quinolinate synthase (BB431_05820), Quinolinate synthase (BB407_01115), Quinolinate synthase (HPY173_04020), Quinolinate synthase (C2R48_04895), Quinolinate synthase A (nadA), Quinolinate synthase (BGL85_03255), Quinolinate synthase (BZK21_01005), Quinolinate synthase (HPF55_0045), Quinolinate synthase (AOD76_0201075), Quinolinate synthase (BB461_05325), Quinolinate synthase (C2R92_05855), Quinolinate synthase (C2S39_00525), Quinolinate synthase (AEY52_07200), Quinolinate synthase A (nadA), Quinolinate synthase (CGC32_07160), Quinolinate synthase (HPF75_0049), Quinolinate synthase (BGL81_03250), Quinolinate synthase (HPF20_0047), Quinolinate synthase (ACM29_05840), Quinolinate synthase A (nadA), Quinolinate synthase (HPMKM6_0049), Quinolinate synthase (C2R73_00155), Quinolinate synthase (ACM28_02565), Quinolinate synthase A (nadA), Quinolinate synthase (C2S04_06770), Quinolinate synthase (C2R70_03895), Quinolinate synthase (C2R85_06720), Quinolinate synthase (BB394_06350), Quinolinate synthase A (nadA), Quinolinate synthase (HPMKM5_0045), Quinolinate synthase (AC782_02175), Quinolinate synthase (C2S44_00045), Quinolinate synthase (BGL58_03270), Quinolinate synthase (C2R82_03550), Quinolinate synthase (C2R72_06525), Quinolinate synthase (BGL87_02485), Quinolinate synthase (BB436_03185), Quinolinate synthase (C2S07_04950), Quinolinate synthase A (nadA), Quinolinate synthase (HPF63_0047), Quinolinate synthase (BIZ48_04360), Quinolinate synthase (BB469_07440), Quinolinate synthase (C2S42_01505), Quinolinate synthase (C2S49_05140), Quinolinate synthase (AA974_06160), Quinolinate synthase (C2S30_03365), Quinolinate synthase (BB414_04340), Quinolinate synthase (C2R57_06195), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (EG63_06695), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (C2R78_00565), Quinolinate synthase (JM68_01315), Quinolinate synthase (BGL70_03090), Quinolinate synthase (C2S26_01385), Quinolinate synthase (BB395_04085), Quinolinate synthase A (nadA), Quinolinate synthase (BB390_03560), Quinolinate synthase A (nadA), Quinolinate synthase (BB397_07615), Quinolinate synthase (BGL62_06235), Quinolinate synthase (AA971_06325), Quinolinate synthase (C2S29_03110), Quinolinate synthase A (nadA), Quinolinate synthase (C2R50_03475), Quinolinate synthase (BB428_03850), Quinolinate synthase (BB447_01570), Quinolinate synthase (ACM24_00465), Quinolinate synthase (AB991_05550), Quinolinate synthase (C2R59_06220), Quinolinate synthase (C2R96_00170), Quinolinate synthase (C2S08_04730), Quinolinate synthase (C2R52_06985), Quinolinate synthase (BB411_06835), Quinolinate synthase (HPF211_0044), Quinolinate synthase A (nadA), Quinolinate synthase (BXP09_07305), Quinolinate synthase (C2S36_00290), Quinolinate synthase (AEY55_07010), Quinolinate synthase A (nadA), Quinolinate synthase (BB459_06300), Quinolinate synthase (HPF210_0043), Quinolinate synthase (BB400_07225), Quinolinate synthase (AV921_0207375), Quinolinate synthase (BZK22_08035), Quinolinate synthase (HPY1846_02420), Quinolinate synthase A (nadA), Quinolinate synthase (ACM32_02395), Quinolinate synthase (BB384_07435), Quinolinate synthase (BZK26_07335), Quinolinate synthase (C2R90_05785), Quinolinate synthase (BGL76_00185), Quinolinate synthase (BB388_00285), Quinolinate synthase (BGL82_01035), Quinolinate synthase A (nadA), Quinolinate synthase (AA977_07105), Quinolinate synthase (AC784_04740), Quinolinate synthase (HPMKM1_0044), Quinolinate synthase A (nadA), Quinolinate synthase (BGL59_02580), Quinolinate synthase (BB392_04940), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (AB891_06965), Quinolinate synthase (BB409_06655), Quinolinate synthase A (nadA), Quinolinate synthase (BB396_07710), Quinolinate synthase (HPF209_0046), Quinolinate synthase (BGL64_00830), Quinolinate synthase (EE66_07745), Quinolinate synthase (BV499_07240), Quinolinate synthase (BB434_03360), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase A (nadA), Quinolinate synthase (BB463_00520), Quinolinate synthase A (nadA), Quinolinate synthase (ACM27_07100)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from iminoaspartate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processPyridine nucleotide biosynthesisSAAS annotation
Ligand4Fe-4SSAAS annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00253;UER00327

Names & Taxonomyi

Protein namesi
Recommended name:
Quinolinate synthaseSAAS annotation (EC:2.5.1.72SAAS annotation)
Gene namesi
ORF Names:BB463_00520Imported, BB479_06030Imported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000220703 Componenti: Unassembled WGS sequence
  • UP000220567 Componenti: Unassembled WGS sequence

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2A6SGT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTDNDLKTS ILELLNDLDA LLVAHFYQKD EIVELAHHTG DSLELAKIAS
60 70 80 90 100
QSDKNLIVFC GVHFMGESVK ALAFDKQVIM PKLSCCSMAR MIDSHYYDRS
110 120 130 140 150
VHLLKEYGVK EFYPITYINS NAEVKAKVAK DDGVVCTSRN ASKIFNHALK
160 170 180 190 200
QNKKIFFLPD KCLGENLALE NGLKSAILGV NSQEEIKNAD VVCYNGFCSV
210 220 230 240 250
HQLFKLEDIE FYRQKYPDIL IAVHPECEPS VVSNADFSGS TSQIIEFVEK
260 270 280 290 300
LSPDQKVAIG TESHLVNRLK AKRHHQNTFI LSSTLAFCPT MNETTLKDLF
310 320 330
EVLKAYKNHR AYNTIELKDE VARLAKLALT KMMELS
Length:336
Mass (Da):37,886
Last modified:December 20, 2017 - v1
Checksum:i580C1A15E652964F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MBKC01000041 Genomic DNA Translation: PDW22020.1
MBJC01000001 Genomic DNA Translation: PDX32160.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MBKC01000041 Genomic DNA Translation: PDW22020.1
MBJC01000001 Genomic DNA Translation: PDX32160.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00253;UER00327

Family and domain databases

InterProiView protein in InterPro
IPR003473 NadA
IPR036094 NadA_sf
PANTHERiPTHR30573 PTHR30573, 1 hit
PfamiView protein in Pfam
PF02445 NadA, 1 hit
SUPFAMiSSF142754 SSF142754, 1 hit
TIGRFAMsiTIGR00550 nadA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A2A6SGT1_HELPX
AccessioniPrimary (citable) accession number: A0A2A6SGT1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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