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Entry version 8 (11 Dec 2019)
Sequence version 1 (20 Dec 2017)
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Protein

Integrase catalytic domain-containing protein

Gene

B5V51_12791

Organism
Heliothis virescens (Tobacco budworm moth)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrase catalytic domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:B5V51_12791Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeliothis virescens (Tobacco budworm moth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7102 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHeliothis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000218220 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2425 – 2446HelicalSequence analysisAdd BLAST22
Transmembranei2572 – 2594HelicalSequence analysisAdd BLAST23
Transmembranei2614 – 2635HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1550 – 1743Integrase catalyticInterPro annotationAdd BLAST194

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni111 – 138DisorderedSequence analysisAdd BLAST28
Regioni553 – 581DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2388 – 2408Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271 Aquaporin-like
IPR005312 DUF1759
IPR040676 DUF5641
IPR022048 Envelope_fusion-like
IPR001584 Integrase_cat-core
IPR041588 Integrase_H2C2
IPR000425 MIP
IPR008737 Peptidase_asp_put
IPR008042 Retrotrans_Pao
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12259 Baculo_F, 1 hit
PF05585 DUF1758, 1 hit
PF03564 DUF1759, 1 hit
PF18701 DUF5641, 1 hit
PF17921 Integrase_H2C2, 1 hit
PF00230 MIP, 1 hit
PF05380 Peptidase_A17, 1 hit
PF00665 rve, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00783 MINTRINSICP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit
SSF81338 SSF81338, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2A4K6T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGTIETQYQ IMQAMNKIVI NFKKDGASRK TTDYVQKKID LLDKYWIEFL
60 70 80 90 100
SNHEKIRERE DPSHEYFVQE FFEKTRQFYN TTRESFVKYL TQEQNPVSPV
110 120 130 140 150
LMPATFTFEP APSTSKLSEQ KFNPEQGTGG VKSGNQSPFS ITVPEAIEIT
160 170 180 190 200
GNSKIDEMLR KQRSNVKAFQ RTVSYINVDL LKEKWQFEDA LKLLESRWKA
210 220 230 240 250
IDSLYWDLDS LPNEAEEQYE ISYNACELVY NQIKSNINTK MWSVSHREKS
260 270 280 290 300
TPKIEIPTFS GSYEHWTAFK DLFVETIHSN PSLSKAQRMQ FLKSKVKGEA
310 320 330 340 350
EKLIQHLSIS SENYETAWEI LNRRYNNKKL IFSSHLNSLL GVPNTQHLSA
360 370 380 390 400
ASVKKLHDTT QECINAIKNL GVDTSSWDPI LVHLLSQKLD AETLNDYLES
410 420 430 440 450
LEEPRELPNL ADFLNFLEGK FVSWETSRRK PETSKGAQSE PTQMKKKYHS
460 470 480 490 500
YKAFSAKQNR NDDYKSNSLT KENEVASKCP HCNQAHKLFS CKEFLELQPD
510 520 530 540 550
EKRKAIAKYN LCKNCLTVHT QSNGCLSRRK CRVCNLEHNT LLHDAYGKWG
560 570 580 590 600
GQTSNNRSLQ QNTAAADSKK TTSSNTNHVS QEDLSETLLT TALINVQAND
610 620 630 640 650
GSLITLRALL DQGSQTSLIT EKAAQRLRIP RGRCKGVIFG VGAKESNCKG
660 670 680 690 700
VIRITCSAIH SDYEFDTDVF IMRNLINNLP NKSFTKPKSW KFLENITLAD
710 720 730 740 750
PDFNESRPVD ILLGADIYSN IIQEGIIRHE KSQPVAQQTR LGWILCGSVQ
760 770 780 790 800
TTFQCNVVIN NLDDIRQFWS VEDIAEDPKM SQDDLDCLQH YKNTTTRNEE
810 820 830 840 850
GRYTVELPFI SNFQEKLGAS KSMALAQFRH LEKKFTKQPQ LAESYRQFIH
860 870 880 890 900
EYQAMNHMVE CTSNTTPACY LPHHCVQRAD STTTALRVVF NASAKTSTGH
910 920 930 940 950
TLNDLMKRGP NLQQDLMSLI LRWRQYQFAY TADVEKMYRA IRCSPEHQNY
960 970 980 990 1000
QKILWRSSPD QRLREYQLTT VTYGMKAAPF LAMMTLKQLA ADEGHKYQDS
1010 1020 1030 1040 1050
RAAEALQEEF YMDDLVSGSF TLSSAKQLQE DLLQLLRSGG FNLRKWSSNN
1060 1070 1080 1090 1100
EELLQNVNRA SSHQAPFDFK QAESTKTLGL QWNPKEDTFT FELKIDATTK
1110 1120 1130 1140 1150
AEKRTKRALL SDISKIFDPL GWLAPITTTL KLLFKQAWLS NIQWDDLLPV
1160 1170 1180 1190 1200
KINTEWEKVR ADLQYISEFR IQRWYKTGEH DTIQLHGFCD ASIKAYACVV
1210 1220 1230 1240 1250
YCKIGTYVTL VAAKTRLVPE NKKLTLPRLE LCGAHLLSSL MQKIVQALHG
1260 1270 1280 1290 1300
REIKIYGWTD STAVLGWIQG NINRWTPFVA NRIRQIKEVI ISDNWYYIKS
1310 1320 1330 1340 1350
ADNPADCASR GITTAQLKQH HLWWYGPQFL PGFNELSVAE RSVYVTDQEE
1360 1370 1380 1390 1400
RKIKQSNVVV QPHSDDVIQY ILHRNSDMAR AVRILAWVLR FSRRQRYRSI
1410 1420 1430 1440 1450
YLHANEQDKA KHMIIKYVQE ENFSEEINSL RKQEPVHRKS KTLCLNPFLD
1460 1470 1480 1490 1500
KDGLLRVGGR LKHANIDEEM KHPLIIPHRS HITDLIIDQA HRRTFHAGAR
1510 1520 1530 1540 1550
MTLAHIRQSY WILGGNRAVR KRLLTCITCK KHKAIKQKQM MGYLPEPRSN
1560 1570 1580 1590 1600
PSRPFHHTGV DYTGYVDVKL NKGRGVKTSK GYIAVFVCMV TKAVHLELVS
1610 1620 1630 1640 1650
DLSSSAFLAA LKRMSSRRGK PHHIYSDNGT NFVGANKALQ QEQAELRKTF
1660 1670 1680 1690 1700
SDGFYAEISE MGIQWHFNAP AWPSAGGLWE AAVKSLKYHL RRVVGEQKLT
1710 1720 1730 1740 1750
FEEYSTLLAQ LEACLNSRPL CTITEDPDDL NYLTPSHFLS SGPILTILDT
1760 1770 1780 1790 1800
EQDERTRWKR TEKIFEDIWK RWKSEYLAQL SARSKWQRPH ENIQVDDVVI
1810 1820 1830 1840 1850
IHEPNLPAGR WALGRVTELH PGSDGLVRVV TLKTKSGYIK RPVIKLSVLV
1860 1870 1880 1890 1900
SNPKATDQTS KISHKQTIKK KDDQSNCRPG TASNLIATLI TLFLFMTTVF
1910 1920 1930 1940 1950
GRQQTASPYS LTTIHKALYF DRISSMQFIR DEWKLIVYHD MSPYWDGSTT
1960 1970 1980 1990 2000
FEKYLQQITN VCERETKKAL CDIIILQLRH AHDELKYYNE MLMNQHIEER
2010 2020 2030 2040 2050
TRKRRGLIDG VGYVANSLFG VLDQRFADQY KQDISLIKRN EEHLALLWKN
2060 2070 2080 2090 2100
QTSVVEAEYN LLKRTEESIN RQHKVINQHL NNLTKATNIL NKNLQEQEVM
2110 2120 2130 2140 2150
NELALSTIIA TNMLAKLKSI QDTIIDTITD IHHGMFSVHL LSPKQLRDQL
2160 2170 2180 2190 2200
SIISGQLSRE LSLPIENIQT ELPKIYHLLK VKARVTQQYL IFEIRIPLIS
2210 2220 2230 2240 2250
RESYDLYQLI SIPQHHGNST VAVVPVSDYI AINLRKDTYL AMTERDIQQC
2260 2270 2280 2290 2300
VQYDDLTRLC HSRKPIFQFK SEDSMCIKET SANRCRTNTA ACRNNWMELS
2310 2320 2330 2340 2350
KTNTYLYYCC GQCALRVICE HQITAIQVAK AGVITLDSDC VIKGEDFTVF
2360 2370 2380 2390 2400
SHKMQHSEVR TATDLESQQI APINHIINVS VPEIEINITD HQASFRHIKE
2410 2420 2430 2440 2450
QIEQMKSEKA LYSEISSHDI HQYSVIYMLV LGAVLTVLVF LCRWFYRRRQ
2460 2470 2480 2490 2500
RSADLQSNSE TQHPKAPVAA CREFATSIVG PPPHTRDASN QSREETVELR
2510 2520 2530 2540 2550
NFNSILSSIK QHKKTPPLAV PEDKVGSFGM TLPGHGVTEA QAVLIEALIT
2560 2570 2580 2590 2600
FLLVMVVHGV CDARRNDIKG SAPLAIGLSI TACHAACIPF SGASMNPARS
2610 2620 2630 2640
IGPALVLGVW TSQWVYWVGP IVGGVIAGLV YKFIFRIGKT GDSGSYDF
Length:2,648
Mass (Da):303,430
Last modified:December 20, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85542D3D698FB4D9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NWSH01000070 Genomic DNA Translation: PCG79985.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NWSH01000070 Genomic DNA Translation: PCG79985.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR005312 DUF1759
IPR040676 DUF5641
IPR022048 Envelope_fusion-like
IPR001584 Integrase_cat-core
IPR041588 Integrase_H2C2
IPR000425 MIP
IPR008737 Peptidase_asp_put
IPR008042 Retrotrans_Pao
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF12259 Baculo_F, 1 hit
PF05585 DUF1758, 1 hit
PF03564 DUF1759, 1 hit
PF18701 DUF5641, 1 hit
PF17921 Integrase_H2C2, 1 hit
PF00230 MIP, 1 hit
PF05380 Peptidase_A17, 1 hit
PF00665 rve, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF53098 SSF53098, 1 hit
SSF81338 SSF81338, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2A4K6T9_HELVI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2A4K6T9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: December 11, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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