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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Bacillus sp. 7705b
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processtRNA processingUniRule annotationSAAS annotation
LigandFADUniRule annotationSAAS annotation, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotationSAAS annotation (EC:2.1.1.74UniRule annotationSAAS annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotationImported
ORF Names:CJU60_11275Imported
OrganismiBacillus sp. 7705bImported
Taxonomic identifieri2028568 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000217863 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A2A2VVI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQQTVNVIG AGLAGSEAAW QLAKRGIQVR LYEMRPVKQT PAHHTDKFAE
60 70 80 90 100
LVCSNSLRSN TLANAVGVLK EEMRALDSAI IAAADECSVP AGGALAVDRH
110 120 130 140 150
EFAASVTNRV KNHPNVTVVN EEVTEIPEGP TIIATGPLTS ESLSAQLKEL
160 170 180 190 200
TGEDYLYFYD AAAPIVEKDS LDMDKVYLKS RYDKGEAAYL NCPMTEEEFD
210 220 230 240 250
RFHEALTSAE TVPLKEFEKE IFFEGCMPIE VMAKRGKKTM LFGPMKPVGL
260 270 280 290 300
EHPVTGKRPY AVVQLRQDDA AGTLYNIVGF QTHLKWGDQK EVLKLIPGLE
310 320 330 340 350
NVEIVRYGVM HRNTFINSPS LLKPTYQFKK RNDLFFAGQM TGVEGYVESA
360 370 380 390 400
ASGLVAGINA AKLVLGEELV TFPQETAIGS MAHYITTTNQ KNFQPMNANF
410 420 430
GLLKDLPVKI KNKKERNEQY ANRAIETIQT ISKTI
Length:435
Mass (Da):48,092
Last modified:December 20, 2017 - v1
Checksum:iEF3357E3FD799EBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NSDH01000028 Genomic DNA Translation: PAY12956.1
RefSeqiWP_024121391.1, NZ_NSDH01000028.1

Entry informationi

Entry nameiA0A2A2VVI3_9BACI
AccessioniPrimary (citable) accession number: A0A2A2VVI3
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: February 28, 2018
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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