Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Urease

Gene
N/A
Organism
Hordeum vulgare subsp. vulgare (Domesticated barley)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease, Urease
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi354Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi356Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi437Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi437Nickel 2; via carbamate groupUniRule annotation1
Binding sitei439SubstratePROSITE-ProRule annotation1
Metal bindingi466Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi492Nickel 2; via tele nitrogenUniRule annotation1
Active sitei540Proton donorUniRule annotation1
Metal bindingi580Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingUniRule annotation, NickelUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00258;UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
UreaseUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolaseUniRule annotation
OrganismiHordeum vulgare subsp. vulgare (Domesticated barley)Imported
Taxonomic identifieri112509 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum
Proteomesi
  • UP000011116 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei437N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 792UreaseInterPro annotationAdd BLAST444

Sequence similaritiesi

In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
cd00407 Urease_beta, 1 hit
Gene3Di2.10.150.10, 1 hit
2.30.40.10, 2 hits
3.30.280.10, 1 hit
HAMAPiMF_01953 Urease_alpha, 1 hit
MF_01954 Urease_beta, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR008221 Urease
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
IPR036463 Urease_gamma_sf
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PF00699 Urease_beta, 1 hit
PIRSFiPIRSF001222 Urease, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51278 SSF51278, 1 hit
SSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
SSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR01792 urease_alph, 1 hit
TIGR00192 urease_beta, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

A0A287STA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GQDRNGPDGP RETDVGQETS SSSCSIPFGH CAGVEGTFMD GTKLITVHDP
60 70 80 90 100
ISSDDGNLEL ALHGSYLPVP SLEKFSGSDV EDYPGEVHFC SGRIILNLHR
110 120 130 140 150
RALTLKVVNK ADRPIQIGSH YHFIEANPYL VFDRLRAYGM RLNIPAGTAV
160 170 180 190 200
RFEPGDAKRV TLVSIGGRKV IRGGNGIADG AVDSSQLNEV IQKITENCFG
210 220 230 240 250
HEDYPDASEG LIGDGIFDCS VDHEKYSSMY GPTTGDKIRL GDTDLFAEIE
260 270 280 290 300
KDFAVYGDEC IFGGGKVLRD GMGQSAGYPA SASLDTVITN AVVIDYTGIY
310 320 330 340 350
KADIGIKDGL IIAIGKAGNP DVMDGVHSNM IVGVNTEVIA AQGMIVTAGG
360 370 380 390 400
IDCHVHFICP QLINEAIASG ITTLVGGGTG PAHGTCATTC TPAPSQMKLM
410 420 430 440 450
LQSTDEFPIN VGFTGKGNTA KPEGLSEIIK AGAMGLKLHE DWGSTPAAID
460 470 480 490 500
NCLSVAEAFD IQVNIHTDTL NEAGCVEHTI AAFKDRSIHT YHSEGAGGGH
510 520 530 540 550
APDIIKVCGV KNVLPSSTNP TRPFTSNTVD EHLDMLMVCH HLDKNIPEDV
560 570 580 590 600
AFAESRIRAE TIAAEDILHD MGAISIISSD SQAMGRIGEV IIRTWQTANK
610 620 630 640 650
MKVQRGWLPG PGESDPAKYN DNFRIRRYIA KYTINPAIVS GFSDFVGSVE
660 670 680 690 700
AGKLADLVLW KPAFFGAKPE LIIKGGAIAW ANMGDPNASI PTPEPVMMRP
710 720 730 740 750
MFGAYGKAGS SHSIAFVSKA AKEAGVASEY KLAKRVEAVG GVRSLTKLDM
760 770 780 790
KLNDALPKIE VDPETYTVTA DGEVLTCQPA ATVPLSRNYF LF
Length:792
Mass (Da):84,359
Last modified:November 22, 2017 - v1
Checksum:i1E46D6402E803D03
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0XRW3M0XRW3_HORVV
Urease
841Annotation score:
M0XRW4M0XRW4_HORVV
Urease
607Annotation score:
A0A287ST09A0A287ST09_HORVV
Urease
547Annotation score:
A0A287ST29A0A287ST29_HORVV
Urease
574Annotation score:
A0A287ST37A0A287ST37_HORVV
Urease
549Annotation score:
A0A287ST99A0A287ST99_HORVV
Urease
551Annotation score:
A0A287ST24A0A287ST24_HORVV
Urease
405Annotation score:
M0XRW6M0XRW6_HORVV
Urease
653Annotation score:
A0A287ST68A0A287ST68_HORVV
Urease
710Annotation score:
A0A287ST85A0A287ST85_HORVV
Urease
691Annotation score:
There are more potential isoformsShow all

Genome annotation databases

EnsemblPlantsiHORVU5Hr1G114090.23; HORVU5Hr1G114090.23; HORVU5Hr1G114090
GrameneiHORVU5Hr1G114090.23; HORVU5Hr1G114090.23; HORVU5Hr1G114090

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiHORVU5Hr1G114090.23; HORVU5Hr1G114090.23; HORVU5Hr1G114090
GrameneiHORVU5Hr1G114090.23; HORVU5Hr1G114090.23; HORVU5Hr1G114090

Enzyme and pathway databases

UniPathwayi
UPA00258;UER00370

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
cd00407 Urease_beta, 1 hit
Gene3Di2.10.150.10, 1 hit
2.30.40.10, 2 hits
3.30.280.10, 1 hit
HAMAPiMF_01953 Urease_alpha, 1 hit
MF_01954 Urease_beta, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR008221 Urease
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR002019 Urease_beta
IPR036461 Urease_betasu_sf
IPR036463 Urease_gamma_sf
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PF00699 Urease_beta, 1 hit
PIRSFiPIRSF001222 Urease, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51278 SSF51278, 1 hit
SSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
SSF54111 SSF54111, 1 hit
TIGRFAMsiTIGR01792 urease_alph, 1 hit
TIGR00192 urease_beta, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A287STA2_HORVV
AccessioniPrimary (citable) accession number: A0A287STA2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: October 10, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again