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Protein

Urease

Gene
N/A
Organism
Hordeum vulgare subsp. vulgare (Domesticated barley)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi169Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi171Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi252Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi252Nickel 2; via carbamate groupUniRule annotation1
Binding sitei254SubstratePROSITE-ProRule annotation1
Metal bindingi281Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi307Nickel 2; via tele nitrogenUniRule annotation1
Active sitei355Proton donorUniRule annotation1
Metal bindingi395Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation
LigandMetal-bindingUniRule annotation, NickelUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UreaseUniRule annotation (EC:3.5.1.5UniRule annotation)
OrganismiHordeum vulgare subsp. vulgare (Domesticated barley)Imported
Taxonomic identifieri112509 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum
Proteomesi
  • UP000011116 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei252N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 549UreaseInterPro annotationAdd BLAST386

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

A0A287ST37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEEKCVLNL LWLRCLPLKF GCSEGLIGDG IFDCSVDHEK YSSMYGPTTG
60 70 80 90 100
DKIRLGDTDL FAEIEKDFAV YGDECIFGGG KVLRDGMGQS AGYPASASLD
110 120 130 140 150
TVITNAVVID YTGIYKADIG IKDGLIIAIG KAGNPDVMDG VHSNMIVGVN
160 170 180 190 200
TEVIAAQGMI VTAGGIDCHV HFICPQLINE AIASGITTLV GGGTGPAHGT
210 220 230 240 250
CATTCTPAPS QMKLMLQSTD EFPINVGFTG KGNTAKPEGL SEIIKAGAMG
260 270 280 290 300
LKLHEDWGST PAAIDNCLSV AEAFDIQVNI HTDTLNEAGC VEHTIAAFKD
310 320 330 340 350
RSIHTYHSEG AGGGHAPDII KVCGVKNVLP SSTNPTRPFT SNTVDEHLDM
360 370 380 390 400
LMVCHHLDKN IPEDVAFAES RIRAETIAAE DILHDMGAIS IISSDSQAMG
410 420 430 440 450
RIGEVIIRTW QTANKMKVQR GWLPGPGESD PAKYNDNFRI RRYIAKYTIN
460 470 480 490 500
PAIVSGFSDF VGSVEAGKLA DLVLWKPAFF GAKPELIIKG GAIAWANMGD
510 520 530 540
PNASIPTPEP VMMRPMFGAY GKAGSSHSIA FVSKAAKEAG VASEYKLAK
Length:549
Mass (Da):58,253
Last modified:November 22, 2017 - v1
Checksum:i1F0BB8479F7F4CBA
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0XRW3M0XRW3_HORVV
Urease
841Annotation score:
A0A287STA2A0A287STA2_HORVV
Urease
792Annotation score:
M0XRW4M0XRW4_HORVV
Urease
607Annotation score:
A0A287ST09A0A287ST09_HORVV
Urease
547Annotation score:
A0A287ST29A0A287ST29_HORVV
Urease
574Annotation score:
A0A287ST99A0A287ST99_HORVV
Urease
551Annotation score:
A0A287ST24A0A287ST24_HORVV
Urease
405Annotation score:
M0XRW6M0XRW6_HORVV
Urease
653Annotation score:
A0A287ST68A0A287ST68_HORVV
Urease
710Annotation score:
A0A287ST85A0A287ST85_HORVV
Urease
691Annotation score:
There are more potential isoformsShow all

Genome annotation databases

EnsemblPlantsiHORVU5Hr1G114090.14; HORVU5Hr1G114090.14; HORVU5Hr1G114090
HORVU5Hr1G114090.15; HORVU5Hr1G114090.15; HORVU5Hr1G114090
HORVU5Hr1G114090.22; HORVU5Hr1G114090.22; HORVU5Hr1G114090
GrameneiHORVU5Hr1G114090.14; HORVU5Hr1G114090.14; HORVU5Hr1G114090
HORVU5Hr1G114090.15; HORVU5Hr1G114090.15; HORVU5Hr1G114090
HORVU5Hr1G114090.22; HORVU5Hr1G114090.22; HORVU5Hr1G114090

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiHORVU5Hr1G114090.14; HORVU5Hr1G114090.14; HORVU5Hr1G114090
HORVU5Hr1G114090.15; HORVU5Hr1G114090.15; HORVU5Hr1G114090
HORVU5Hr1G114090.22; HORVU5Hr1G114090.22; HORVU5Hr1G114090
GrameneiHORVU5Hr1G114090.14; HORVU5Hr1G114090.14; HORVU5Hr1G114090
HORVU5Hr1G114090.15; HORVU5Hr1G114090.15; HORVU5Hr1G114090
HORVU5Hr1G114090.22; HORVU5Hr1G114090.22; HORVU5Hr1G114090

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A287ST37_HORVV
AccessioniPrimary (citable) accession number: A0A287ST37
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: October 10, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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