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Protein

Deoxyribonuclease

Gene

DNASE1

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei100UniRule annotation1
Active sitei156UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
DeoxyribonucleaseUniRule annotation
Gene namesi
Name:DNASE1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501153961223 – 284DeoxyribonucleaseSequence analysisAdd BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 126UniRule annotation
Disulfide bondi195 ↔ 231Essential for enzymatic activityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 274Endo/exonuclease/phosphataseInterPro annotationAdd BLAST233

Sequence similaritiesi

Belongs to the DNase I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000013146
OMAiRYLFVFR

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR018057 Deoxyribonuclease-1_AS
IPR016202 DNase_I
IPR033125 DNASE_I_2
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PIRSFiPIRSF000988 DNase_I_euk, 1 hit
PRINTSiPR00130 DNASEI
SMARTiView protein in SMART
SM00476 DNaseIc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS00919 DNASE_I_1, 1 hit
PS00918 DNASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

A0A287BNY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAARLMGAL LALAGLLQLA LSLRIAAFNI RTFGETKMSN ATLSNYIVRI
60 70 80 90 100
LSRYDIALIQ EVRDSHLTAV GKLLNELNQD DPNNYHHVVS EPLGRSTYKE
110 120 130 140 150
RYLFVFRPDQ VSVLDSYLYD DGCEPCGNDT FNREPSVVKF SSPFTQVKEF
160 170 180 190 200
AIVPLHAAPS DAAAEIDSLY DVYLNVRQKW DLEDIMLMGD FNAGCSYVTT
210 220 230 240 250
SHWSSIRLRE SPPFQWLIPD TADTTVSSTH CAYDRIVVAG PLLQRAVVPD
260 270 280
SAAPFDFQAA FGLSEQTALA ISDHYPVEVT LKRA
Length:284
Mass (Da):31,686
Last modified:November 22, 2017 - v1
Checksum:i1348DA680D1E18C8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P11936DNAS1_PIG
Deoxyribonuclease-1
DNASE1 DNL1
284Annotation score:
A0A287BJ79A0A287BJ79_PIG
Deoxyribonuclease
DNASE1
275Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000018 Genomic DNA No translation available.
RefSeqiXP_013851153.1, XM_013995699.1
XP_013851154.1, XM_013995700.1
XP_013851155.1, XM_013995701.1
UniGeneiSsc.9

Genome annotation databases

EnsembliENSSSCT00000042628; ENSSSCP00000058337; ENSSSCG00000036527
GeneIDi397051

Similar proteinsi

Entry informationi

Entry nameiA0A287BNY8_PIG
AccessioniPrimary (citable) accession number: A0A287BNY8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: April 25, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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