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Entry version 28 (10 Feb 2021)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

GTPase KRas isoform X2

Gene

KRAS

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandGTP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-1169092, Activation of RAS in B cells
R-SSC-1250347, SHC1 events in ERBB4 signaling
R-SSC-1433557, Signaling by SCF-KIT
R-SSC-171007, p38MAPK events
R-SSC-179812, GRB2 events in EGFR signaling
R-SSC-180336, SHC1 events in EGFR signaling
R-SSC-186763, Downstream signal transduction
R-SSC-1963640, GRB2 events in ERBB2 signaling
R-SSC-210993, Tie2 Signaling
R-SSC-2179392, EGFR Transactivation by Gastrin
R-SSC-2424491, DAP12 signaling
R-SSC-2871796, FCERI mediated MAPK activation
R-SSC-375165, NCAM signaling for neurite out-growth
R-SSC-4086398, Ca2+ pathway
R-SSC-5218921, VEGFR2 mediated cell proliferation
R-SSC-5654688, SHC-mediated cascade:FGFR1
R-SSC-5654693, FRS-mediated FGFR1 signaling
R-SSC-5654699, SHC-mediated cascade:FGFR2
R-SSC-5654700, FRS-mediated FGFR2 signaling
R-SSC-5654704, SHC-mediated cascade:FGFR3
R-SSC-5654706, FRS-mediated FGFR3 signaling
R-SSC-5654712, FRS-mediated FGFR4 signaling
R-SSC-5654719, SHC-mediated cascade:FGFR4
R-SSC-5658442, Regulation of RAS by GAPs
R-SSC-5673000, RAF activation
R-SSC-5673001, RAF/MAP kinase cascade
R-SSC-5674135, MAP2K and MAPK activation
R-SSC-5675221, Negative regulation of MAPK pathway
R-SSC-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805, MET activates RAS signaling
R-SSC-8951936, RUNX3 regulates p14-ARF
R-SSC-9607240, FLT3 Signaling
R-SSC-9634635, Estrogen-stimulated signaling through PRKCZ
R-SSC-9648002, RAS processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GTPase KRas isoform X2Imported
Submitted name:
KRAS proto-oncogene, GTPaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRASImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:89569, KRAS

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A287B854, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A287B854

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni168 – 188DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi170 – 188BasicSequence analysisAdd BLAST19

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155871

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYKLVVM

Database of Orthologous Groups

More...
OrthoDBi
1259506at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type

The PANTHER Classification System

More...
PANTHERi
PTHR24070, PTHR24070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51421, RAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A287B854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI
110 120 130 140 150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QDLARSYGIP FIETSAKTRQ
160 170 180
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SKTKCIIM
Length:188
Mass (Da):21,439
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1B6C319BB259861
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3LCQ9I3LCQ9_PIG
GTPase KRas isoform X1
KRAS
189Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000034 Genomic DNA No translation available.
DQIR01159158 Transcribed RNA Translation: HDB14635.1

NCBI Reference Sequences

More...
RefSeqi
XP_003126475.1, XM_003126427.4
XP_005653209.1, XM_005653152.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000042185; ENSSSCP00000052259; ENSSSCG00000026969

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100518251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100518251

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000034 Genomic DNA No translation available.
DQIR01159158 Transcribed RNA Translation: HDB14635.1
RefSeqiXP_003126475.1, XM_003126427.4
XP_005653209.1, XM_005653152.2

3D structure databases

SMRiA0A287B854
ModBaseiSearch...

Genome annotation databases

EnsembliENSSSCT00000042185; ENSSSCP00000052259; ENSSSCG00000026969
GeneIDi100518251
KEGGissc:100518251

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3845
VGNCiVGNC:89569, KRAS

Phylogenomic databases

GeneTreeiENSGT00940000155871
OMAiEYKLVVM
OrthoDBi1259506at2759

Enzyme and pathway databases

ReactomeiR-SSC-1169092, Activation of RAS in B cells
R-SSC-1250347, SHC1 events in ERBB4 signaling
R-SSC-1433557, Signaling by SCF-KIT
R-SSC-171007, p38MAPK events
R-SSC-179812, GRB2 events in EGFR signaling
R-SSC-180336, SHC1 events in EGFR signaling
R-SSC-186763, Downstream signal transduction
R-SSC-1963640, GRB2 events in ERBB2 signaling
R-SSC-210993, Tie2 Signaling
R-SSC-2179392, EGFR Transactivation by Gastrin
R-SSC-2424491, DAP12 signaling
R-SSC-2871796, FCERI mediated MAPK activation
R-SSC-375165, NCAM signaling for neurite out-growth
R-SSC-4086398, Ca2+ pathway
R-SSC-5218921, VEGFR2 mediated cell proliferation
R-SSC-5654688, SHC-mediated cascade:FGFR1
R-SSC-5654693, FRS-mediated FGFR1 signaling
R-SSC-5654699, SHC-mediated cascade:FGFR2
R-SSC-5654700, FRS-mediated FGFR2 signaling
R-SSC-5654704, SHC-mediated cascade:FGFR3
R-SSC-5654706, FRS-mediated FGFR3 signaling
R-SSC-5654712, FRS-mediated FGFR4 signaling
R-SSC-5654719, SHC-mediated cascade:FGFR4
R-SSC-5658442, Regulation of RAS by GAPs
R-SSC-5673000, RAF activation
R-SSC-5673001, RAF/MAP kinase cascade
R-SSC-5674135, MAP2K and MAPK activation
R-SSC-5675221, Negative regulation of MAPK pathway
R-SSC-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-SSC-8851805, MET activates RAS signaling
R-SSC-8951936, RUNX3 regulates p14-ARF
R-SSC-9607240, FLT3 Signaling
R-SSC-9634635, Estrogen-stimulated signaling through PRKCZ
R-SSC-9648002, RAS processing

Gene expression databases

ExpressionAtlasiA0A287B854, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR020849, Small_GTPase_Ras-type
PANTHERiPTHR24070, PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421, RAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A287B854_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A287B854
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 28 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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