Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein tyrosine phosphatase, non-receptor type 3

Gene

PTPN3

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei679SubstrateUniRule annotation1
Active sitei710Phosphocysteine intermediateUniRule annotation1
Binding sitei754SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, non-receptor type 3Imported
Gene namesi
Name:PTPN3Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181FERMInterPro annotationAdd BLAST181
Domaini378 – 450PDZInterPro annotationAdd BLAST73
Domaini514 – 769Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini687 – 760TYR_PHOSPHATASE_2InterPro annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni710 – 716Substrate bindingUniRule annotation7

Phylogenomic databases

GeneTreeiENSGT00760000118823

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A287ARF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDICEGRLTC PLNSAVVLAS YAVQSHFGDH DSSIHPPGYL SDSQFIPDQN
60 70 80 90 100
DDFLTKVESL HEQHSGLKQS EAESCFINIA RTLDFYGVEL HSGRDLHNLD
110 120 130 140 150
LMIGIASAGI AVYRKYICTS FYPWVNILKI SFKRKKFFIH QRQKQTESRE
160 170 180 190 200
HIVAFNMLNY RSCKNLWKSC VEHHTFFQAK KLLPQEKNVL SQYWTMGSRN
210 220 230 240 250
PKKSVNNQYC KKVIGGMVWN PAMRRSLSVE HLETKSLPSR SPPITPNWRS
260 270 280 290 300
PRLRHEIRKP RHSSADNLAN EMTYITETED VFYTYKGSMS PKDSDSEVSQ
310 320 330 340 350
NRSPHRESIS ENNAAHGCLT QKSSSSASPS SNAPGSCSPD GVDQQFLEDF
360 370 380 390 400
HRVTKGGSTE DSSQYYCDKN DGDGYLVLIR ITPDEEGKFG FNLKGGVDQK
410 420 430 440 450
MPLVVSRINP ESPADTCIPK LNEGDQIVLI NGRDISEHTH DQVVMFIKAS
460 470 480 490 500
RESHTRELVL VIRRKAVHSF ADIKSEDELN QLFPEAIFPM CPEGGDTLEG
510 520 530 540 550
SMEQLKKGLE SGTVLIQFEQ LYRKKPGLAI TFAKLPQNLD KNRYKDVLPY
560 570 580 590 600
DTTRVLLQGN EDYINASYVN MEIPAAHLVN KYIAAQGPLP HTCAQFWQVV
610 620 630 640 650
WDQKLSLIVM LTTLTERGRT KCHQYWPNPP DVMEHGSFHI RCRSEDCTIA
660 670 680 690 700
YVFREMLVTN TETGEEHTVT HLQYVAWPDH GVPDDSSDFL EFVNYVRSLR
710 720 730 740 750
VDGEPVVVHC SAGIGRTGVL VTMETAMCLI ERNLPVYPLD IVRKMRDQRA
760 770 780
MMVQTSSQYK FVCEAILRVY EEGLVQMLDP S
Length:781
Mass (Da):88,739
Last modified:November 22, 2017 - v1
Checksum:iC52E65FFC1E1F0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000005 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000037525; ENSSSCP00000046477; ENSSSCG00000005449

Similar proteinsi

Entry informationi

Entry nameiA0A287ARF0_PIG
AccessioniPrimary (citable) accession number: A0A287ARF0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: May 23, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health