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Entry version 21 (07 Oct 2020)
Sequence version 1 (22 Nov 2017)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3870S-adenosyl-L-methionineUniRule annotation1
Binding sitei3872S-adenosyl-L-methionineUniRule annotation1
Binding sitei3914S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3940ZincUniRule annotation1
Metal bindingi3988ZincUniRule annotation1
Binding sitei3989S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3990ZincUniRule annotation1
Metal bindingi3995ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1180 – 1228CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-3214841, PKMTs methylate histone lysines
R-SSC-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-SSC-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A287AIX3, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1180 – 1228CXXC-typeInterPro annotationAdd BLAST49
Domaini1464 – 1515PHD-typeInterPro annotationAdd BLAST52
Domaini1512 – 1566PHD-typeInterPro annotationAdd BLAST55
Domaini1599 – 1660PHD-typeInterPro annotationAdd BLAST62
Domaini1736 – 1781BromoInterPro annotationAdd BLAST46
Domaini1903 – 2011PHD-typeInterPro annotationAdd BLAST109
Domaini2051 – 2107FYR N-terminalInterPro annotationAdd BLAST57
Domaini3697 – 3778FYR C-terminalInterPro annotationAdd BLAST82
Domaini3860 – 3976SETInterPro annotationAdd BLAST117
Domaini3984 – 4000Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 80DisorderedSequence analysisAdd BLAST80
Regioni188 – 264DisorderedSequence analysisAdd BLAST77
Regioni279 – 300DisorderedSequence analysisAdd BLAST22
Regioni358 – 377DisorderedSequence analysisAdd BLAST20
Regioni478 – 635DisorderedSequence analysisAdd BLAST158
Regioni746 – 979DisorderedSequence analysisAdd BLAST234
Regioni1071 – 1100DisorderedSequence analysisAdd BLAST30
Regioni1138 – 1198DisorderedSequence analysisAdd BLAST61
Regioni1233 – 1408DisorderedSequence analysisAdd BLAST176
Regioni1696 – 1737DisorderedSequence analysisAdd BLAST42
Regioni1839 – 1902DisorderedSequence analysisAdd BLAST64
Regioni2114 – 2166DisorderedSequence analysisAdd BLAST53
Regioni2179 – 2207DisorderedSequence analysisAdd BLAST29
Regioni2280 – 2368DisorderedSequence analysisAdd BLAST89
Regioni2394 – 2495DisorderedSequence analysisAdd BLAST102
Regioni2533 – 2652DisorderedSequence analysisAdd BLAST120
Regioni2678 – 2709DisorderedSequence analysisAdd BLAST32
Regioni2746 – 2830DisorderedSequence analysisAdd BLAST85
Regioni2835 – 2854DisorderedSequence analysisAdd BLAST20
Regioni2969 – 3078DisorderedSequence analysisAdd BLAST110
Regioni3165 – 3279DisorderedSequence analysisAdd BLAST115
Regioni3501 – 3675DisorderedSequence analysisAdd BLAST175
Regioni3816 – 3839DisorderedSequence analysisAdd BLAST24
Regioni3937 – 3938S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili406 – 426Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 58Pro-richSequence analysisAdd BLAST22
Compositional biasi237 – 259PolyampholyteSequence analysisAdd BLAST23
Compositional biasi478 – 528PolarSequence analysisAdd BLAST51
Compositional biasi568 – 588PolarSequence analysisAdd BLAST21
Compositional biasi589 – 609Pro-richSequence analysisAdd BLAST21
Compositional biasi746 – 764PolarSequence analysisAdd BLAST19
Compositional biasi780 – 878PolarSequence analysisAdd BLAST99
Compositional biasi879 – 931PolyampholyteSequence analysisAdd BLAST53
Compositional biasi957 – 979PolarSequence analysisAdd BLAST23
Compositional biasi1079 – 1094PolarSequence analysisAdd BLAST16
Compositional biasi1267 – 1281PolarSequence analysisAdd BLAST15
Compositional biasi1282 – 1305PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1335 – 1350Pro-richSequence analysisAdd BLAST16
Compositional biasi1359 – 1373Pro-richSequence analysisAdd BLAST15
Compositional biasi1855 – 1880Pro-richSequence analysisAdd BLAST26
Compositional biasi2129 – 2151PolarSequence analysisAdd BLAST23
Compositional biasi2281 – 2353PolarSequence analysisAdd BLAST73
Compositional biasi2435 – 2451PolarSequence analysisAdd BLAST17
Compositional biasi2452 – 2478PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2559 – 2627PolarSequence analysisAdd BLAST69
Compositional biasi2754 – 2779PolarSequence analysisAdd BLAST26
Compositional biasi2780 – 2817PolyampholyteSequence analysisAdd BLAST38
Compositional biasi2969 – 2984PolarSequence analysisAdd BLAST16
Compositional biasi2995 – 3010PolarSequence analysisAdd BLAST16
Compositional biasi3044 – 3078PolarSequence analysisAdd BLAST35
Compositional biasi3165 – 3181PolarSequence analysisAdd BLAST17
Compositional biasi3197 – 3216PolarSequence analysisAdd BLAST20
Compositional biasi3229 – 3248PolarSequence analysisAdd BLAST20
Compositional biasi3263 – 3279PolarSequence analysisAdd BLAST17
Compositional biasi3501 – 3560PolarSequence analysisAdd BLAST60
Compositional biasi3571 – 3596PolyampholyteSequence analysisAdd BLAST26
Compositional biasi3597 – 3637PolarSequence analysisAdd BLAST41
Compositional biasi3644 – 3660PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1180 – 1228CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160099

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A287AIX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTWGGG GGGRRGLGGA PRQRVPALLL PPGPPGGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAGSG GAGVPGGAAA ASAASSSSAS SSSSSSSSAS
110 120 130 140 150
SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGELTTQIP
160 170 180 190 200
CSWRTKGLIH DKKTEPFRLL AWSWCLNDEQ FLGFGSDEEV RVRSPTRSPS
210 220 230 240 250
VKTSPRKPRG RPRSGSDRNS ALLSDPPVFS PLNKSETRPG DKIKKKDSKS
260 270 280 290 300
IEKKRGRPPT FPGVKLKITH GKDITELPKG NKEDSLKKMK RTPSATFQQA
310 320 330 340 350
TKIKKLRAGK LSPLKSKFKT GKLQIGRKGV QIVRRRGRPP STERIKTPAG
360 370 380 390 400
LLINSELEKP QKVRKDKEGT PPLTKEDKTV VRQSPRRIKP VRIIPSSKRT
410 420 430 440 450
DATIAKQLLQ RAKKGAQKKI EKEAAQLQGR KVKTQVKNIR QFIMPVVSAI
460 470 480 490 500
SSRIIKTPRR FIEDEDYDPP IKIARLESTP NSRFSATSCG SSEKSSAASQ
510 520 530 540 550
HSSQMSSDSS RSSSPSVDTS TDSQASEEIQ VLPEERSDTP EVHTPLPISQ
560 570 580 590 600
SPENESTDRR SRRYSVSERS FGSRTTKKLS TLQSAPPQQT SSSPPPPLLT
610 620 630 640 650
PPPPLQPASS ISDHTPWLMP PTIPLASPFL PTSAAPMQGK RKSILREPTF
660 670 680 690 700
RWTSLKHSRS EPQYFSSAKY AKEGLIRKPI FDNFRPPPLT PEDVGFASGF
710 720 730 740 750
STSGTAASAR LFSPLHSGTR FDMHKRSPLL RAPRFTPSEA HSRIFESVTL
760 770 780 790 800
PSNRTSAGTS SSGLSNRKRK RKVFSPIRSE PRSPSHSMRT RSGRLSTSEL
810 820 830 840 850
SPLTPPSSVS SSLSISVSPL ATSALNPTFT FPSHSLTQSG ESAEKNQRPR
860 870 880 890 900
KQTSAPAEPF SSSSPTPLFP WFTPGSQTER GRNKDKAPEE LSKERDADKS
910 920 930 940 950
VEKDKSRERD REREKENKRE SRKEKRKKGS EIQSSSALYP VGRVSKEKVV
960 970 980 990 1000
DEDVATSSSA KKATGRKKSS SLDSGTDIAS VTLGDTTAVK TKILIKKGRG
1010 1020 1030 1040 1050
NLEKNNLDLG PTAPSLEKEK TLCLSTPSSS TVKHSTSSIG SMLAQADKLP
1060 1070 1080 1090 1100
MTDKRVASLL KKAKAQLCKI EKSKSLKQTD QPKAQGQESD SSETSVRGPR
1110 1120 1130 1140 1150
IKHVCRRAAV ALGRKRAVFP DDMPTLSALP WEEREKILSS MGNDDKSSIA
1160 1170 1180 1190 1200
GSEDAEPLAP PIKPIKPVTR NKAPQEPPVK KGRRSRRCGQ CPGCQVPEDC
1210 1220 1230 1240 1250
GVCTNCLDKP KFGGRNIKKQ CCKMRKCQNL QWMPSKAYLQ KQAKAVKKKE
1260 1270 1280 1290 1300
KKSKTSEKKE SKESSVVKNL VDSSQKSTPA AREDPTPKKS NSEPPPRKPV
1310 1320 1330 1340 1350
EDKSEEGNAS ASAPEAKQVA APTSRKSNKQ ASQPTPAIPP QPPSTAPPRK
1360 1370 1380 1390 1400
EVPKTTPSEP KKKQPPPPEP GPEQSKQKKV APRPSIPVKQ KPKEKEKPPP
1410 1420 1430 1440 1450
VNKQENAGTL NILSTFSNGN SSKQKIPADG VHRIRVDFKE DCEAENVWEM
1460 1470 1480 1490 1500
GGLGILTSVP ITPRVVCFLC ASSGHVEFVY CQVCCEPFHK FCLEENERPL
1510 1520 1530 1540 1550
EDQLENWCCR RCKFCHVCGR QHQATKQLLE CNKCRNSYHP ECLGPNYPTK
1560 1570 1580 1590 1600
PTKKKKVWIC TKCVRCKSCG STTPGKGWDA QWSHDFSLCH DCAKLFAKGN
1610 1620 1630 1640 1650
FCPLCDKCYD DDDYESKMMQ CGKCDRWVHS KCENLSDEMY EILSNLPESV
1660 1670 1680 1690 1700
AYTCVNCTER HPAEWRLALE KELQISLKQV LTALLNSRTT SHLLRYRQAA
1710 1720 1730 1740 1750
KPPDLNPETE ESIPSRSSPE GPDPPVLTEV SKQEDQQPLD LEGVKRKMDQ
1760 1770 1780 1790 1800
GNYTSVLEFS DDIVKIIQAA INSDGGQPEI KKANSMVKSF FIRQMERVFP
1810 1820 1830 1840 1850
WFSVKKSRFW EPNKVSSNSG MLPNAVLPPS LDHNYAQWQE REENSHTEQP
1860 1870 1880 1890 1900
PLMKKIIPAP KPKGPGEPDS PTPLHPPTPP ILSTDRSRED SPELNPPPGI
1910 1920 1930 1940 1950
EDNRQCALCL TYGDDSANDA GRLLYIGQNE WTHVNCALWS AEVFEDDDGS
1960 1970 1980 1990 2000
LKNVHMAVIR GKQLRCEFCQ KPGATVGCCL TSCTSNYHFM CSRAKNCVFL
2010 2020 2030 2040 2050
DDKKVYCQRH RDLIKGEVVP ENGFEVFRRV FVDFEGISLR RKFLNGLEPE
2060 2070 2080 2090 2100
NIHMMIGSMT IDCLGILNDL SDCEDKLFPI GYQCSRVYWS TTDARKRCVY
2110 2120 2130 2140 2150
TCKIVECRPP VVEPDINSTV EHDENRTIAH SPSSFAEISS KESQNTAEIV
2160 2170 2180 2190 2200
SPPSPDRPPH SQTSGSCFYH VISKVPRIRT PSYSPTQRSP GCRPLPSAGS
2210 2220 2230 2240 2250
PTPTTHEIVT VGDPLLSSGL RSIGSRRHST SSLSPQRSKL RIMSPMRTGG
2260 2270 2280 2290 2300
TYSRNSVSSL STIGTTTDLE SSAKAADHVL GPLNSNTNLG QNTPTSSNLQ
2310 2320 2330 2340 2350
RTVVTLGTKT SHLDGPSSSE MKHSSASDST SKSSSLKGEK TKMPSSKNSE
2360 2370 2380 2390 2400
GSAHNVAYPG IPKLAPQVHN TTSGELNVSK MGTFAELSSV PFSSKEALPF
2410 2420 2430 2440 2450
PPLHLRGQRN DRDQQPDSNQ LANPPPDEDT EVKTLKLSGV SSRASTISEH
2460 2470 2480 2490 2500
VGSSSRDRRQ KGKKSGKDTF KEKHSSKSFL EPGQVTTGEE GNLKPEFMDE
2510 2520 2530 2540 2550
VLTPEFMGQR PCNNVSSDKI GDKVHSIAGV PKAASMQVEG SAKELQTPRK
2560 2570 2580 2590 2600
RTVKVTLTPL KMESESQSKN TLKESSPVSP LQIEPASPTE PVSASESPGD
2610 2620 2630 2640 2650
GPVAQPSPNN TSSQDSQSNS YQNLPVQDRN LMLPDGPKPQ EDGSFKRRYP
2660 2670 2680 2690 2700
RRSARARSNM FFGLTPLYGV RSYGEEDIPF YSSSTGKKRG KRSAEGQVDG
2710 2720 2730 2740 2750
ADDLSTSDED DLYYYNFTRT VIASGGEERL ASHNLFREEE QCDLPKISQL
2760 2770 2780 2790 2800
DGVDDGTESD TSVTATTRKS SQIPKRNSKE NGTENLKMDR PEDAGEKEHV
2810 2820 2830 2840 2850
IKSSVGHKNE PKMDNCHSVS RVKTQGQDSL EAQLSSLESG RRVHTSTPSD
2860 2870 2880 2890 2900
KNLLDTYNTE LLKSDSDNNN SDDCGNILPS DIMDFVLKNT PSMQALGESP
2910 2920 2930 2940 2950
ESSSSELLNL GEGLGLDSNR EKDMGLFEVF SQQLPTAEPV DSSVSSSISA
2960 2970 2980 2990 3000
EEQFELPLEL PSDLSVLTTR SPTVPSQNPS RLAVISDSGE KRVSITEKSV
3010 3020 3030 3040 3050
ASSESDSALL SPGVDPTPEG HMTPDHFIQG HMDADHISSP PCGSVEQGHG
3060 3070 3080 3090 3100
NNQDLTRNSS TPGLQVPVSP TVPIQNQKYV PNSTDSPGPS QISNAAVQTT
3110 3120 3130 3140 3150
PPHLKPATEK LIVVNQNMQP LYVLQTLPNG VTQKIQLTSS VSSAPNVMET
3160 3170 3180 3190 3200
NTSVLGPMGS GLTLTTGLNP SLPTSQSLFP PASKGLLPMP HHQHLHSFPA
3210 3220 3230 3240 3250
ATQSSFPTNI SSPPSGLLIG VQPPPDPQLL VSEASQRTDL STTVATPPSG
3260 3270 3280 3290 3300
LKKRPISRLQ NRKNKKLAPS STPSNIAPSD VVSNMTLINF TPSQLPNHPN
3310 3320 3330 3340 3350
LLDLGSLNAS SHRTVPNIIK RSKSSIMYFE QAPLLPQSVG GSAAPAAGTS
3360 3370 3380 3390 3400
TISQDAGHLT SGPVSGLASG SSVLNVVSMQ TTTAPTSSAS VPGHVALTNP
3410 3420 3430 3440 3450
RLLGTPDIGS ISNLLIKASQ QSLGIQDQSV ALPPSSGMFP QLGTSQTPST
3460 3470 3480 3490 3500
AAMTAASSIC VLPSTQTAGI TAASPSGDTD EHYQLQHVNQ LLASKTGILS
3510 3520 3530 3540 3550
SQRDLDSAPG TQGSNFTQTV DAPNNMGLEQ NKTLSSAMQA SSTSPGGSPS
3560 3570 3580 3590 3600
SGQQSASPSV PAPTKPKPKS KRIQLPLDKG SGKKHKVSHL RTSSEAHIPD
3610 3620 3630 3640 3650
QEASTTALTS VTGTPGAEAE QQETASVEQS SQKGCGQPAG QVAVLPEIQT
3660 3670 3680 3690 3700
TQNPVNEQEN SEPKTAEEEE SNFSSPLMLW LQQEQKRKES IAEKKPKKGL
3710 3720 3730 3740 3750
VFEISSDDGF QICAESIEDA WKSLTDKVQE ARSNARLKQL SFAGVNGLRM
3760 3770 3780 3790 3800
LGILHDAVVF LIEQLSGAKH CRNYKFRFHK PEEANEPPLN PHGSARAEVH
3810 3820 3830 3840 3850
LRKSAFDMFN FLASKHRQPP EYNPNDEEEE EVQLKSARRA TSMDLPMPMR
3860 3870 3880 3890 3900
FRHLKKTSKE AVGVYRSPIH GRGLFCKRNI DAGEMVIEYA GNVIRSIQTD
3910 3920 3930 3940 3950
KREKYYDSKG IGCYMFRIDD SEVVDATMHG NAARFINHSC EPNCYSRVIN
3960 3970 3980 3990 4000
IDGQKHIVIF AMRKIYRGEE LTYDYKFPIE DASNKLPCNC GAKKCRKFLN
Length:4,000
Mass (Da):435,154
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i802B5C1F93B3E79F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287BFC1A0A287BFC1_PIG
Histone-lysine N-methyltransferase
KMT2A
3,687Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286ZRD9A0A286ZRD9_PIG
Histone-lysine N-methyltransferase
KMT2A
3,967Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A287B3M7A0A287B3M7_PIG
Histone-lysine N-methyltransferase
KMT2A
3,684Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000070 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000041538; ENSSSCP00000043846; ENSSSCG00000023324

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000070 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSSCT00000041538; ENSSSCP00000043846; ENSSSCG00000023324

Phylogenomic databases

GeneTreeiENSGT00940000160099

Enzyme and pathway databases

ReactomeiR-SSC-3214841, PKMTs methylate histone lysines
R-SSC-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-SSC-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene expression databases

ExpressionAtlasiA0A287AIX3, baseline and differential

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A287AIX3_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A287AIX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: October 7, 2020
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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