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Protein

Elongator complex protein 3

Gene

ELP3

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandIron, Iron-sulfurUniRule annotation, Metal-binding, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3UniRule annotation (EC:2.3.1.48UniRule annotation)
Gene namesi
Name:ELP3Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini487 – 638N-acetyltransferaseInterPro annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013141

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A287A5Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPILPLYSKA CILQPLTPAR LPPEPFYPAS CGSASRRWEA GRTLALFRDQ
60 70 80 90 100
LYDTWTVILR QDGVALWLSI FSEVRIRRYF FCGGGWHGSG EMRQKRKGDL
110 120 130 140 150
SPAELMMLTI GDVIKQLIEA HEQGKDIDLN KVKTRTAAKY GLSAQPRLVD
160 170 180 190 200
IIAAVPPQYR KVLVPKLKAK PIRTASGIAV VAVMCKPHRC PHISFTGNIC
210 220 230 240 250
VYCPGGPDSD FEYSTQSYTG YEPTSMRAIR ARYDPYLQTR HRIEQLKQLG
260 270 280 290 300
HSVDKVEFIV MGGTFMALPE EYRDYFIRNL HDALSGHTSN NIYEAVKYSE
310 320 330 340 350
RSLTKCVGIT IETRPDYCMK RHLSDMLTYG CTRLEIGVQS VYEDVARDTN
360 370 380 390 400
RGHTVKAVCE SFHLAKDSGF KVVAHMMPDL PNVGLERDIE QFTEFFENPA
410 420 430 440 450
FRPDGLKLYP TLVIRGTGLY ELWKSGRYKS YSPSDLIELV ARILALVPPW
460 470 480 490 500
TRVYRVQRDI PMPLVSSGVE HGNLRELAFA RMKDLGIQCR DVRTREVGIQ
510 520 530 540 550
EIHHKVRPYQ VELVRRDYVA NGGWETFLSY EDPDQDILIG LLRLRKCSEE
560 570 580 590 600
TFRFELVGGV SIVRELHVYG SVVPVSSRDP TKFQHQGFGM LLMEEAERIA
610 620 630
REEHGSGKIA VISGVGTRNY YRKIGYRLQG PYMVKTLK
Length:638
Mass (Da):72,661
Last modified:November 22, 2017 - v1
Checksum:iF55F85FA991450AC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1RJR2F1RJR2_PIG
Elongator complex protein 3
ELP3
533Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000096 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000050177; ENSSSCP00000039280; ENSSSCG00000009674

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000096 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000050177; ENSSSCP00000039280; ENSSSCG00000009674

Phylogenomic databases

GeneTreeiENSGT00390000013141

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A287A5Q9_PIG
AccessioniPrimary (citable) accession number: A0A287A5Q9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: July 18, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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