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Protein

L-lactate dehydrogenase

Gene

LDHA

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase C chain (LDHC), L-lactate dehydrogenase A chain (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHAL6B), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase (LDHA), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHA)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:LDHAImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Expressioni

Gene expression databases

ExpressionAtlasiA0A286ZNX3 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 245Ldh_1_NInterPro annotationAdd BLAST139
Domaini249 – 409Ldh_1_CInterPro annotationAdd BLAST161

Phylogenomic databases

GeneTreeiENSGT00550000074541

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A286ZNX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKPLGCARC AAFLQLRLEF FQNQRARDFG FFSEVAAKLV PQVQEAPPAS
60 70 80 90 100
RSEYRSSCRQ VRIRHCAPPT PARSALPIPF GSKSTMATLK DQLIHNLLKE
110 120 130 140 150
EHVPHNKITV VGVGAVGMAC AISILMKELA DEIALVDVME DKLKGEMMDL
160 170 180 190 200
QHGSLFLRTP KIVSGKDYNV TANSRLVVIT AGARQQEGES RLNLVQRNVN
210 220 230 240 250
IFKFIIPNIV KYSPNCKLLV VSNPVDILTY VAWKISGFPK NRVIGSGCNL
260 270 280 290 300
DSARFRYLMG ERLGVHPLSC HGWILGEHGD SSVPVWSGVN VAGVSLKNLH
310 320 330 340 350
PELGTDADKE HWKAVHKQVV DSAYEVIKLK GYTSWAIGLS VADLAESIMK
360 370 380 390 400
NLRRVHPIST MIKGLYGIKE DVFLSVPCIL GQNGISDVVK VTLTPEEEAH
410
LKKSADTLWG IQKELQF
Length:417
Mass (Da):46,039
Last modified:November 22, 2017 - v1
Checksum:i961C8F04368A7F0F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P00339LDHA_PIG
L-lactate dehydrogenase A chain
LDHA
332Annotation score:
A0A287B2H7A0A287B2H7_PIG
L-lactate dehydrogenase
LDHA
361Annotation score:
A0A286ZP12A0A286ZP12_PIG
L-lactate dehydrogenase
LDHA
388Annotation score:
A0A287AFC1A0A287AFC1_PIG
L-lactate dehydrogenase
LDHA
346Annotation score:
A0A287AD16A0A287AD16_PIG
L-lactate dehydrogenase
LDHA
279Annotation score:
A0A286ZXT7A0A286ZXT7_PIG
L-lactate dehydrogenase
LDHA
443Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000009 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000053481; ENSSSCP00000033168; ENSSSCG00000013366

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000009 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000053481; ENSSSCP00000033168; ENSSSCG00000013366

Phylogenomic databases

GeneTreeiENSGT00550000074541

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Gene expression databases

ExpressionAtlasiA0A286ZNX3 baseline and differential

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A286ZNX3_PIG
AccessioniPrimary (citable) accession number: A0A286ZNX3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: October 10, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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