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Entry version 17 (12 Aug 2020)
Sequence version 1 (22 Nov 2017)
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Protein
Submitted name:

Protein furry homolog-like

Gene

FRYL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein furry homolog-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FRYLImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29127, FRYL

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000075539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A286YEZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A286YEZ9, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini140 – 199MOR2-PAG1_midInterPro annotationAdd BLAST60
Domaini285 – 406MOR2-PAG1_midInterPro annotationAdd BLAST122
Domaini548 – 800MOR2-PAG1_CInterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 47DisorderedSequence analysisAdd BLAST25
Regioni1007 – 1042DisorderedSequence analysisAdd BLAST36
Regioni1055 – 1086DisorderedSequence analysisAdd BLAST32
Regioni1095 – 1114DisorderedSequence analysisAdd BLAST20
Regioni1186 – 1212DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1415 – 1449Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 39PolarSequence analysisAdd BLAST17
Compositional biasi1010 – 1034PolarSequence analysisAdd BLAST25
Compositional biasi1186 – 1205AcidicSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086058

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid

The PANTHER Classification System

More...
PANTHERi
PTHR12295, PTHR12295, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A0A286YEZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XGVTHMDNPP YYRITSSYKI PSVTSGTTSS SNTMVAPTDG NPDNKPIKEN
60 70 80 90 100
IEESYVHLDI YSGLNSHLNR QHHRLESRYS SSSGGSYEEE KSDSMPLYSN
110 120 130 140 150
WRLKVMEHNQ GEPLPFPPAG GCWSPLVDYV PETSSPGLPL HRCNIAVILL
160 170 180 190 200
TDLIIDHSVK VEWGSYLHLL LHAIFIGFDH CHPEVYEHCK RLLLHLLIVM
210 220 230 240 250
GPNSNIRTVA SVLLRNKEFN EPRVLTVKQV AHLDYNFTAG INDFIPDYQP
260 270 280 290 300
SPMTDSGLSS SSTSSSISLG NNSAAISHLH TTILNEVDIS VEQDGKVKTL
310 320 330 340 350
MEFITSRKRG PLWNHEDVSA KNPSIKSAEQ LTTFLKHVVS VFKQSSSEGI
360 370 380 390 400
HLEHHLSEVA LQTALSCSSR HYAGRSFQIF RALKQPLTAT TLSDVLSRLV
410 420 430 440 450
ETVGDPGEDA QGFVIELLLT LESAIDTLAE TMKHYDLLSA LSQTSYHDPI
460 470 480 490 500
MGNKYAANRK STGQLNLSTS PINSSSYLGY NSNARSNSLR LSLIGDRRGD
510 520 530 540 550
RRRSNTLDIM DGRINHSSSL ARTRSLSSLR EKGMYDVQST TEPTNLMATI
560 570 580 590 600
FWIAASLLES DYEYEYLLAL RLLNKLLIHL PLDKSESREK IENVQSKLKW
610 620 630 640 650
TNFPGLQQLF LKGFTSASTQ EMTVHLLSKL ISVSKHTLVD PSQLSGFPLN
660 670 680 690 700
ILCLLPHLIQ HFDSPTQFCK ETASRIAKVC AEEKCPTLVN LAHMMSLYST
710 720 730 740 750
HTYSRDCSNW INVVCRYLHD SFSDTTFNLV TYLAELLEKG LSSMQQSLLQ
760 770 780 790 800
IIYSLLSHID LSAAPAKQFN LEIIKIIGKY VQSPYWKEAL NILKLVVSRS
810 820 830 840 850
ASLVVPSDIP KTYGGDTGSP EISFTKIFNN VSKELPGKTL DFHFDISETP
860 870 880 890 900
IIGNKYGDQH SAAGRNGKPK VIAVTRSTSS TSSGSNSNAL VPVSWKRPQL
910 920 930 940 950
SQRRTREKLM NVLSLCGPES GLPKNPSVVF SSNEDLEVGD QQTSLISTTE
960 970 980 990 1000
DINQEEEVAV EDNSSEQQFG VFKDFDFLDV ELEDAEELQG ESMDNFNWGV
1010 1020 1030 1040 1050
RRRSLDSIDK GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ
1060 1070 1080 1090 1100
ILSRTQMLNS DSATDETIPD HPDLLLQSED STGSITTEEV LQIRDETPTL
1110 1120 1130 1140 1150
EASLDNANSR LPEDTTSVLK EEHVTTFEDE GSYIIQEQQE SLVCQGILDL
1160 1170 1180 1190 1200
EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD FSGLSSQDEE
1210 1220 1230 1240 1250
EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG
1260 1270 1280 1290 1300
SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM
1310 1320 1330 1340 1350
MLCSECPTVF VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL
1360 1370 1380 1390 1400
DDCKRTFGAK EDMYRINTDA QQMEILAELE LCRRLYKLHF QLLLLFQAYC
1410 1420 1430 1440 1450
KLINQVNTIK NEAEVINMSE ELAQLESILK EAESASENEE IDISKAAQTT
1460 1470 1480 1490 1500
IETAIHSLIE TLKNKEFISA VAQVKAFRSL WPSDIFGSCE DDPVQTLLHI
1510 1520 1530 1540 1550
YFHHQTLGQT GSFAVIGSNL DMSEANYKLM ELNLEIRESL RMVQSYQLLA
1560
QAKPMGNMVS TGF
Length:1,563
Mass (Da):174,671
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19429853CAE0DF3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O94915FRYL_HUMAN
Protein furry homolog-like
FRYL AF4P12, KIAA0826
3,013Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2S2F2Z2S2_HUMAN
Protein furry homolog-like
FRYL
1,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9F2R7A0A2C9F2R7_HUMAN
Protein furry homolog-like
FRYL
1,716Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9X0H0Y9X0_HUMAN
Protein furry homolog-like
FRYL
1,455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6E1XQM6A0A6E1XQM6_HUMAN
Protein furry homolog-like
FRYL
1,233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KB90A0A669KB90_HUMAN
Protein furry homolog-like
FRYL
964Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9B9D6R9B9_HUMAN
Protein furry homolog-like
FRYL
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000641795; ENSP00000493144; ENSG00000075539

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068037 Genomic DNA No translation available.
AC096952 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Proteomic databases

PeptideAtlasiA0A286YEZ9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23821, 27 antibodies

Genome annotation databases

EnsembliENST00000641795; ENSP00000493144; ENSG00000075539

Organism-specific databases

HGNCiHGNC:29127, FRYL
OpenTargetsiENSG00000075539

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00610000086058

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FRYL, human

Gene expression databases

ExpressionAtlasiA0A286YEZ9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR025481, Cell_Morphogen_C
IPR039867, Furry/Tao3/Mor2
IPR029473, MOR2-PAG1_mid
PANTHERiPTHR12295, PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225, MOR2-PAG1_C, 1 hit
PF14228, MOR2-PAG1_mid, 2 hits
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A286YEZ9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A286YEZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: August 12, 2020
This is version 17 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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