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Protein
Submitted name:

Dynein, cytoplasmic 1, intermediate chain 2a

Gene

dync1i2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2500257 Resolution of Sister Chromatid Cohesion
R-DRE-2565942 Regulation of PLK1 Activity at G2/M Transition
R-DRE-380259 Loss of Nlp from mitotic centrosomes
R-DRE-380270 Recruitment of mitotic centrosome proteins and complexes
R-DRE-380320 Recruitment of NuMA to mitotic centrosomes
R-DRE-5620912 Anchoring of the basal body to the plasma membrane
R-DRE-5663220 RHO GTPases Activate Formins
R-DRE-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Submitted name:
Dynein, cytoplasmic 1, intermediate chain 2aImported
Gene namesi
Name:dync1i2aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-060929-1086 dync1i2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 577WD_REPEATS_REGIONInterPro annotationAdd BLAST298

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 41Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110228

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR025956 DYNC1I1/DYNC1I2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF11540 Dynein_IC2, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A286YAG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKEAELK KDAVPLQDDS
60 70 80 90 100
DLEKKRREAD ALLQSMGITS DVSAAPAPMS PTAKSVGSPS EAGSQDSGDG
110 120 130 140 150
TTGPRRGPLK LAMTKMTHVD FPPKEVVSYT KETQTPTMTE QKDEEDEEEE
160 170 180 190 200
TPAAQPEAET EKEKPEEKQV EEALPHELTE EEKLQILHSE EFMDFFDHST
210 220 230 240 250
RIVERALSEH VDVFFDYSGR DMEEKEGEMQ AGTKLSLNRK FVDDRWSKQR
260 270 280 290 300
VVTCLDWSPQ YPELLVASYN NNEEAPHEPD GVALVWNMKY KKATPEYVFH
310 320 330 340 350
CQSAVMSAAF AKFHPNLVVG GTYSGQIVLW DNRSNRRTPV QRTPLSAAAH
360 370 380 390 400
THPVYCVNVV GTQNAHNLIS ISTDGKMCSW SLDMLSQPQD SMELVFKQSK
410 420 430 440 450
SVAVTSMSFP LGDVNNFVVG SEDGSVYTAS RHGSRAGISE MFEGHHGPIT
460 470 480 490 500
GIHCHTAAGP VDFSHLFLTA SFDWTVKLWS NKNNKPLYSF EDNSDYVYDV
510 520 530 540 550
MWSPVHPALF ACVDGLGRVD LWNLNNDTEV PTASVAVDGS PALNRLRWSQ
560 570 580 590 600
SGREIAVGDS EGQIHIYDVG EQIAVPRNDE WTRFVRTLVE INENRDDAEE

LAAQRLAA
Length:608
Mass (Da):68,167
Last modified:November 22, 2017 - v1
Checksum:i8F5E4A5C64939819
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7F6H7E7F6H7_DANRE
Dynein, cytoplasmic 1, intermediate...
dync1i2a
626Annotation score:
A0A0R4IU59A0A0R4IU59_DANRE
Dynein, cytoplasmic 1, intermediate...
dync1i2a
326Annotation score:
A0A0R4IHQ1A0A0R4IHQ1_DANRE
Dynein, cytoplasmic 1, intermediate...
dync1i2a
308Annotation score:
A0A0R4IPR1A0A0R4IPR1_DANRE
Dynein, cytoplasmic 1, intermediate...
dync1i2a
471Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU222541 Genomic DNA No translation available.
CU929261 Genomic DNA No translation available.
FP245477 Genomic DNA No translation available.
FQ377636 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000179022; ENSDARP00000144159; ENSDARG00000078386
ENSDART00000182108; ENSDARP00000150754; ENSDARG00000078386

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU222541 Genomic DNA No translation available.
CU929261 Genomic DNA No translation available.
FP245477 Genomic DNA No translation available.
FQ377636 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000179022; ENSDARP00000144159; ENSDARG00000078386
ENSDART00000182108; ENSDARP00000150754; ENSDARG00000078386

Organism-specific databases

ZFINiZDB-GENE-060929-1086 dync1i2a

Phylogenomic databases

GeneTreeiENSGT00730000110228

Enzyme and pathway databases

ReactomeiR-DRE-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-DRE-2467813 Separation of Sister Chromatids
R-DRE-2500257 Resolution of Sister Chromatid Cohesion
R-DRE-2565942 Regulation of PLK1 Activity at G2/M Transition
R-DRE-380259 Loss of Nlp from mitotic centrosomes
R-DRE-380270 Recruitment of mitotic centrosome proteins and complexes
R-DRE-380320 Recruitment of NuMA to mitotic centrosomes
R-DRE-5620912 Anchoring of the basal body to the plasma membrane
R-DRE-5663220 RHO GTPases Activate Formins
R-DRE-8854518 AURKA Activation by TPX2

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR025956 DYNC1I1/DYNC1I2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF11540 Dynein_IC2, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A286YAG4_DANRE
AccessioniPrimary (citable) accession number: A0A286YAG4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: September 12, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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