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Protein
Submitted name:

Myosin VIIAa

Gene

myo7aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-2453902 The canonical retinoid cycle in rods (twilight vision)

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin VIIAaImported
Gene namesi
Name:myo7aaImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-020709-1 myo7aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 752Myosin motorInterPro annotationAdd BLAST677
Domaini1028 – 1264MyTH4InterPro annotationAdd BLAST237
Domaini1269 – 1577FERMInterPro annotationAdd BLAST309
Domaini1575 – 1644SH3InterPro annotationAdd BLAST70
Domaini1720 – 1869MyTH4InterPro annotationAdd BLAST150
Domaini1875 – 2178FERMInterPro annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni629 – 651Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili871 – 946Sequence analysisAdd BLAST76
Coiled coili1091 – 1111Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140810

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd01381 MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 2 hits
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 2 hits
PF00612 IQ, 3 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
SSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 2 hits
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A0A286Y9F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIKARRLSY RCTILVQGDY VWLDLKTGHE FEVPIGAVVK LCDSGQIQVL
60 70 80 90 100
DDEGNEHWIS PQNATNIKPM HPTSIHGVED MIRLGDLNEA GILRNLLIRY
110 120 130 140 150
REHLIYTYTG SILVAVNPYQ LLPIYTADQI RLYTNKKIGE MPPHIFAIAD
160 170 180 190 200
NCYFNMQRNN KDQCCIISGE SGAGKTESTK LILQFLAAIS GQHSWIEQQV
210 220 230 240 250
LEANPILEAF GNAKTIRNDN SSRFGKYIDI HFNKRGAIEG AKIEQYLLEK
260 270 280 290 300
SRVCRQARDE RNYHIFYCML KGMTPDQKKQ LGLSKATDYT YLTIGNCTVC
310 320 330 340 350
DGRDDQKEYS NIRSAMKVLM FTDKENWEIS KLLAAILHMG NLRYEARTYD
360 370 380 390 400
NLDACEVVRC SALTTAAVLL EVDLKDLMNC LTSRTIITRG ETVSTPLSIE
410 420 430 440 450
QALDVRDAFV KGIYGRLFVW IVEKINAAIY KPPSLELKAV RRSIGLLDIF
460 470 480 490 500
GFENFMVNSF EQLCINFANE NLQQFFVRHV FKLEQEEYNL ENINWQHIEF
510 520 530 540 550
TDNQDALDMI AIKPMNIISL IDEESKFPKG TDTTMLNKLN SQHKLNTNYI
560 570 580 590 600
PPKNTYETQF GIQHFAGVVY YETRGFLEKN RDTLHGDIIQ LVHSSKNKFI
610 620 630 640 650
KQIFQADVAM GAETRKRSPT LSSQFKRSLE LLMRTLSVCQ PFFVRCIKPN
660 670 680 690 700
EYKKPMLFDR ELCVRQLRYS GMMETIRIRR AGYPIRYTFV EFVDRYRVLM
710 720 730 740 750
PGVKPAYKQE DLRGTCQRIA EAVLGRDDDW QMGKTKIFLK DHHDMLLEIE
760 770 780 790 800
RDKAITDKVI LIQKVVRGFK DRSNFLKMKK SAMLIQKTWR GYYCRKNYGA
810 820 830 840 850
MRGGFSRLQA LYRSRKLYQT YHVARQRIML FQGRCRGFLV RRAFRHRLWA
860 870 880 890 900
VITIQAYTRG MIARRLYKRL KGEYRRRLEA EKLRLAEEQK LRNQMSARKA
910 920 930 940 950
KEEAEKMHQE RLAQLAREDA EREKKERQEA RRKMEMLDQM EKARQEPVND
960 970 980 990 1000
SDMVDKMFGF LGTTNSFPGQ EGQAPAGFED LERTHRELEV EDLDESLPLP
1010 1020 1030 1040 1050
EDDLEDLSEY KFAKFSATYF QGTSTHTYMR RPLKQPLLFH EDEGDQLAAL
1060 1070 1080 1090 1100
AVWITVLRFM GDLPEPKYHT AISDGSEKIP VMTKIYETLG KKTYKRELQA
1110 1120 1130 1140 1150
LQGEGENTNI ESHKKSSVRH KLVSLTLKKK SKITEEVTKR LNDGEYTVHG
1160 1170 1180 1190 1200
NSMLEDRPTS NLEKLHFIIG NGILRPGLRD EIYCQICKQL NQNPSKSSHA
1210 1220 1230 1240 1250
RGWILMSLCV GCFAPSEKFV KYLRNFISEG PPGYAPYCEE RLRRTFVNGT
1260 1270 1280 1290 1300
RTQPPSWLEL QATKSKKPIM LPVTFMDGTT KTLLTDSATT AKELCNALSD
1310 1320 1330 1340 1350
KISLQDRFGF SLYIALFDKV SSLGSGNDHV MDAVSQCEQY AKEQGAQERN
1360 1370 1380 1390 1400
APWRLFFRKE IFTPWHDPAE DAVATNLIYQ QIVRGVKFGE YRCDREDLAE
1410 1420 1430 1440 1450
LASQQYYVDY GSEILVERLL SLIPSYIPDR EISSAKTVER WAQFIMAAHK
1460 1470 1480 1490 1500
KGVYTQKRVD PQKVKEEVVD FARYKWPLLF SRFYEAFKFS GPSLPKNDVI
1510 1520 1530 1540 1550
VAVNWTGVYF VDEQEQVLLE LSFPEITAVS SSKGGKLQAQ SFTLATIKAD
1560 1570 1580 1590 1600
EFTFTSNNAE DIRDLVVTFL EGLRKRSKFV VALQDNPSPA ADDSTFLSFL
1610 1620 1630 1640 1650
KGDLIVLDQD TGEQVMTSGW AHGTNDRTKQ RGDFPADCVY VLPTVVRPPH
1660 1670 1680 1690 1700
DVVAFVTMTP DQRQESLRIS HVPALTETEE RVKPYTLEEF SYDYFRPPPK
1710 1720 1730 1740 1750
HTLSRVMITK NRGKDKLWCC TREPIKQALL KKCGGHEELS QEACMAFIAV
1760 1770 1780 1790 1800
MKYMGDYPSK RTRSVNELTD QIFEGALKAE PLKDEIYCQI LKQLTENHIK
1810 1820 1830 1840 1850
YSEEKGWELL WLCVGLFPPS NVLLPHVQRF LQSKKHHPLA LDCMQRLQKA
1860 1870 1880 1890 1900
LRNGSRKYPP HLVEVEAIQH KTTQIFHKVY FPDDTDEAFE VESSTKAKDF
1910 1920 1930 1940 1950
CLNISSRLLL KTPEGFSLFV KISDKVISVP EGDFFFDFVR HLTDWIKKAR
1960 1970 1980 1990 2000
PAKDGIVPSL TYQVFFMKKL WTTTVPGKDS FADSIFHYYQ ELPKYLRGYH
2010 2020 2030 2040 2050
KCSREEVFQL GALIYRVKFE DDKSHFPSIP KMLKEMIPQD LIRQLSPDDW
2060 2070 2080 2090 2100
KRSIVAYFNR HAGKSREEAK LMFLKIIFKW PTFGSAFFEV KQTTEPHFPE
2110 2120 2130 2140 2150
ILLIAINKYG VSLIDPKNKD ILTTYPFTKI SNWSSGNTYF HITIGNLVQG
2160 2170 2180 2190
SKLLCETSLG YKMDDLLTSY ISQMLTTMSK QRNSRGGSSK
Length:2,190
Mass (Da):252,993
Last modified:June 20, 2018 - v2
Checksum:iCC044F63E1B80564
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9DGG8Q9DGG8_DANRE
Myosin VIIA
myo7aa myo7A, myo7a
2,179Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU459145 Genomic DNA No translation available.
FO834908 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSDART00000174975; ENSDARP00000143601; ENSDARG00000099871

Similar proteinsi

Entry informationi

Entry nameiA0A286Y9F5_DANRE
AccessioniPrimary (citable) accession number: A0A286Y9F5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: June 20, 2018
Last modified: September 12, 2018
This is version 10 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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