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Entry version 9 (05 Jun 2019)
Sequence version 1 (22 Nov 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

SIPA1L3

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1L3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCavia porcellus (Guinea pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10141 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005447 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini597 – 814Rap-GAPInterPro annotationAdd BLAST218
Domaini952 – 1016PDZInterPro annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 160DisorderedSequence analysisAdd BLAST118
Regioni217 – 320DisorderedSequence analysisAdd BLAST104
Regioni1032 – 1494DisorderedSequence analysisAdd BLAST463
Regioni1507 – 1554DisorderedSequence analysisAdd BLAST48
Regioni1567 – 1631DisorderedSequence analysisAdd BLAST65
Regioni1674 – 1701DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1711 – 1766Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 65PolarSequence analysisAdd BLAST23
Compositional biasi89 – 125PolarSequence analysisAdd BLAST37
Compositional biasi262 – 279PolyampholyteSequence analysisAdd BLAST18
Compositional biasi290 – 315PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1067 – 1110PolarSequence analysisAdd BLAST44
Compositional biasi1183 – 1203PolarSequence analysisAdd BLAST21
Compositional biasi1246 – 1270PolarSequence analysisAdd BLAST25
Compositional biasi1288 – 1311PolarSequence analysisAdd BLAST24
Compositional biasi1364 – 1378PolarSequence analysisAdd BLAST15
Compositional biasi1410 – 1433PolarSequence analysisAdd BLAST24
Compositional biasi1514 – 1531PolarSequence analysisAdd BLAST18
Compositional biasi1580 – 1614PolarSequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159183

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF15 PTHR15711:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A286XGV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYRPLPND GVDLAASCGA RGTDVLPGPH TGDYTSMGFW AQNGSMSQPL
60 70 80 90 100
SESPATATTR PSPTTPAMPK MGVRARVADW PPKREALREQ NNPSPSQDTD
110 120 130 140 150
GMKATKVTHS MRSIQNGQPP ASTPAASGSK AFHRISRRRS KDVEFQDGWP
160 170 180 190 200
RSPGRAFLPL RHRSSSEITL SECDVEDMVE PRGPRHTGGV LPLFREYGST
210 220 230 240 250
SSIDVQGVPE QSFFDILNEF RSEQPDASGG QSLSEFLQAD PGHGTKGDSR
260 270 280 290 300
NGQPPKDNLL PLQPLKEKEK ARKKPTRGLA SGDTVDSSIF RKLRSCKPEG
310 320 330 340 350
EASRTLGEAE EGRSPPEASR PWVCQKSFAH FDVQSMLFDL NEAAANRVSV
360 370 380 390 400
AQRRNTTTGA SAASAASTMA SLTASRAHSL GGLDLAFTST EDLNCKENLE
410 420 430 440 450
QDLGDDNSND LLLSCPHFRN EIGGECERNV SFSRASVGSP GEGHLAEPAL
460 470 480 490 500
STYRTNASIS VLEVPKEQQR TQNRPRQYSI EHVDLGARYY QDYFVGKEHA
510 520 530 540 550
NYFGVDEKLG PVAVSIKREK LEDHKDHGPQ YQYRIIFRTR ELITLRGSIL
560 570 580 590 600
EDATPTATKH GTGRGLPLKD ALEYVIPELN IHCLRLALNT PKVTEQLLKL
610 620 630 640 650
DEQGLCQKHK VGILYCKAGQ SSEEEMYNNE EAGPAFEEFL ELLGEKVCLK
660 670 680 690 700
GFTKYAAQLD VKTDSTGTHS LYTTYQDYEI MFHVSTLLPY TPNNRQQLLR
710 720 730 740 750
KRHIGNDIVT IIFQEPGALP FTPKNIRSHF QHVFIIVRVH NPCTENVCYS
760 770 780 790 800
MAVTRSKDAP PFGPPIPNGT TFRKSDVFRD FLLAKVINAE NAAHKSDKFH
810 820 830 840 850
TMATRTRQEY LKDLAENCVS NTPIDSTGKF NLISLTSKKK EKTKARAGAE
860 870 880 890 900
QHSAGAIAWR VAAQDYAQGV EIDCILGISN EFVVLLDLRT KEVVFNCYCG
910 920 930 940 950
DVIGWTPDSS TLKIFYGRGD HIFVQAAEGS VEDIREIVQR LKVMTNGWET
960 970 980 990 1000
VDMTLRRNGL GQLGFHVKYD GTVAEVEDYG FAWQAGLRQG SRLVEICKVA
1010 1020 1030 1040 1050
VVTLTHDQMI DLLRTSVTVK VVIIPPFEDG TPRRGWPETY EMNTSEPKTE
1060 1070 1080 1090 1100
PESIAPGGRP PYRSNAPWQW SGPSSHNSLP ASKWVTPATP GHAQSLNRPP
1110 1120 1130 1140 1150
KQTSMVPFRE SQPPHSKRPV SFPETPYTAS PAGADRVPPY RQPSGSFSTP
1160 1170 1180 1190 1200
GSVTYARYKP SPERYAAAPH PLLSFDPHFS HDGMSSGDSS SGGLTSQEST
1210 1220 1230 1240 1250
MERQKPEPLW HVPAQARLST IAGSSGSKHV PRQDAAGKDS PNRHSKGEPQ
1260 1270 1280 1290 1300
YSSHSSSNTL SSNASSSHSD DRWFDPLDPL EPEQDPLSKG GSSDSGIDTT
1310 1320 1330 1340 1350
LYTSSPSCMS LAKAPRPTKS HKPPGSMGLS GGGREAAGRP HHTDRRREVS
1360 1370 1380 1390 1400
PAPAVAGQSK GYRPKLYSSG SSTPTGLAGG SRDLPRQPSD MGSRAGYPAQ
1410 1420 1430 1440 1450
VYKMASAETP RPSQLAQSGP FQLSTSVPKS FFSKQPVRNK HPAGWKRMDE
1460 1470 1480 1490 1500
PPPRLLPFTD PKKQVDASTK NVFGQPRLRA SLRDLRSPRK NYKSTIEDDL
1510 1520 1530 1540 1550
KKLIIMDNLG PEQERDTGSP QKSLQRTLSD ESLCSGRREP SFANPASLEP
1560 1570 1580 1590 1600
GLPSDVLFTS TCAFPSSTLP ARRQHQHPLP PGSSGGSSSN SPSTIPATGN
1610 1620 1630 1640 1650
GFPEKKSAIS TSELSLADGR DRPLRRLDPG MMPLPDTAAG LEWSSLVNAA
1660 1670 1680 1690 1700
KAYEVQRAVS LFSLNDPTLS PDVPPAHSPV HSHLSLERAP PAPRTTPTMS
1710 1720 1730 1740 1750
EEPALDLSGK VHQLEVMLKQ LHTDLQKEKQ DKVVLQSEVA SLRQNNQRLQ
1760 1770
EESQAASEQL RKFAELFSRE KKEL
Length:1,774
Mass (Da):194,560
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F96D1CF29A8892C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0VLR9H0VLR9_CAVPO
Uncharacterized protein
SIPA1L3
1,767Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAKN02042197 Genomic DNA No translation available.
AAKN02042198 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005002599.1, XM_005002542.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCPOT00000032201; ENSCPOP00000024708; ENSCPOG00000012585
ENSCPOT00000038209; ENSCPOP00000022039; ENSCPOG00000012585

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100731274

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02042197 Genomic DNA No translation available.
AAKN02042198 Genomic DNA No translation available.
RefSeqiXP_005002599.1, XM_005002542.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000032201; ENSCPOP00000024708; ENSCPOG00000012585
ENSCPOT00000038209; ENSCPOP00000022039; ENSCPOG00000012585
GeneIDi100731274

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23094

Phylogenomic databases

GeneTreeiENSGT00940000159183

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF15 PTHR15711:SF15, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A286XGV7_CAVPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A286XGV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: June 5, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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