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Entry version 11 (05 Jun 2019)
Sequence version 1 (22 Nov 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

HDLBP

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDLBPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCavia porcellus (Guinea pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10141 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005447 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini284 – 352KHInterPro annotationAdd BLAST69
Domaini356 – 424KHInterPro annotationAdd BLAST69
Domaini429 – 497KHInterPro annotationAdd BLAST69
Domaini498 – 564KHInterPro annotationAdd BLAST67
Domaini569 – 637KHInterPro annotationAdd BLAST69
Domaini641 – 710KHInterPro annotationAdd BLAST70
Domaini715 – 783KHInterPro annotationAdd BLAST69
Domaini787 – 856KHInterPro annotationAdd BLAST70
Domaini861 – 930KHInterPro annotationAdd BLAST70
Domaini934 – 1003KHInterPro annotationAdd BLAST70
Domaini1007 – 1104KHInterPro annotationAdd BLAST98
Domaini1105 – 1171KHInterPro annotationAdd BLAST67
Domaini1183 – 1254KHInterPro annotationAdd BLAST72
Domaini1258 – 1327KHInterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1047 – 1079DisorderedSequence analysisAdd BLAST33
Regioni1365 – 1399DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili409 – 429Sequence analysisAdd BLAST21
Coiled coili625 – 645Sequence analysisAdd BLAST21
Coiled coili911 – 938Sequence analysisAdd BLAST28
Coiled coili984 – 1008Sequence analysisAdd BLAST25
Coiled coili1156 – 1176Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1063 – 1079PolyampholyteSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141059

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.10, 14 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00013 KH_1, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00322 KH, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A286XDJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFKIPLLL GHRVAGTRVS GAAPLPRCLS TVKGANFLAP TLTARPRTPG
60 70 80 90 100
VGGPAGTPAG GAGAAGLTCL GGIGAAALYS RAGPGAEPRS PASPVRCGAV
110 120 130 140 150
RRCVAWRGVV RRARTDSGRG THDGLPGFRV GVRSTMSSVA VLTQESFAEH
160 170 180 190 200
RSGLVPQQIK VATLNSEEES DPPTYKDAFP PLPEKSACLE SAQEPAGAWN
210 220 230 240 250
NKIRPIKASV ITQVFHVPLE ERKYKDMNQF GEGEQAKICL EIMQRTGAHL
260 270 280 290 300
ELSLAKDQGL SIMVSGKLDA VMKARKDIVA RLQTQASATV PIPKEHHRFV
310 320 330 340 350
IGKNGEKLQD LELKTATKIQ IPRPDDPSNQ IKITGTKEGI EKARHEVLLI
360 370 380 390 400
SAEQDKRAVE RLEVEKAFHP FIAGPYNRLV GEIMQETGTR INIPPPSVSR
410 420 430 440 450
TEIVFTGEKE QLAQAVARIK KIYEEKKKKT TTIAVEVKKS QHKYVIGPKG
460 470 480 490 500
NSLQEILERT GVSVEIPPSD STSETVILRG EPEKLGQALT EVYAKANSFT
510 520 530 540 550
VSSVSAPSWL HRFIIGKKGQ NLAKITQQMP KVHIEFTEGE DKITLEGPTE
560 570 580 590 600
DVTVAQEQIE SMVKDLINRM DYVEINIDHR FHRHLIGKSG ANINRIKDQY
610 620 630 640 650
KVSVRIPPDS EKSNLIRIEG DPQGVQQAKR ELLDLASRME NERTKDLIIE
660 670 680 690 700
QRFHRTIIGQ KGERIREIRD KFPEVIINFP DPAQKSDIVQ LRGPKNEVEK
710 720 730 740 750
CTKYMQKMVA DLVENSYSIS VPIFKQFHKN IIGKGGANIK KIREESNTKI
760 770 780 790 800
DLPAENSNSE TIVITGKRAN CEAARSRILS IQKDLANIAE VEVSIPAKLH
810 820 830 840 850
NSLIGTKGRL IRSIMEECGG VHIHFPVEGS GSDTVVIRGP SSDVEKAKKQ
860 870 880 890 900
LLHLAEEKQT KSFTVDIRAK PEYHKFLIGK GGGKIRKVRD STGARIIFPA
910 920 930 940 950
AEDKDQDLIT IIGKEDAVRE AQRELEALIQ NLDNVVEDYM LVDPKHHRHF
960 970 980 990 1000
VIRRGQVLRE IAEEYGGVMV SFPRSGTQSD KVTLKGAKDC VEAAKKRIQE
1010 1020 1030 1040 1050
IIEDLEAQVT MECAIPQKFH RSVMGPKGSR IQQITRDYNV QIKFPDREET
1060 1070 1080 1090 1100
PAHGMEPAIQ ENGDEASEGR EADPGSPRRC DIITISGRKE KCEAAKEALE
1110 1120 1130 1140 1150
ALVPVTIEVE VPFDLHRYII GQKGSGIRKM MDEFEVNIHV PAPELQSDVI
1160 1170 1180 1190 1200
AITGLAANLD RAKAGLLERV KELQAEQEDR ALRSFKLNVT VDPRYHPKII
1210 1220 1230 1240 1250
GRKGAVITQI RLEHDVNIQF PDKDDGSQPQ DQITITGYEK NTEAARDAIL
1260 1270 1280 1290 1300
KIVGELEQMV SEDVPLDHRV HARIIGARGK AIRKIMDEFK VDIRFPQSGA
1310 1320 1330 1340 1350
PDPNCVTVTG LPENVEEAID HILNLEEEYL ADVVDTEALQ VYMKPPAHEE
1360 1370 1380 1390
AKAPSKGFVV RDAPWASSSE KAPDMSSSEE FPSFGAQVAP KTLPWGPKR
Length:1,399
Mass (Da):154,687
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30880866861ED19D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286XPE5A0A286XPE5_CAVPO
Uncharacterized protein
HDLBP
1,264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0V7G7H0V7G7_CAVPO
Uncharacterized protein
HDLBP
1,195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAKN02019251 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCPOT00000047840; ENSCPOP00000023520; ENSCPOG00000006297

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02019251 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000047840; ENSCPOP00000023520; ENSCPOG00000006297

Phylogenomic databases

GeneTreeiENSGT00900000141059

Family and domain databases

Gene3Di3.30.1370.10, 14 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 14 hits
SMARTiView protein in SMART
SM00322 KH, 14 hits
SUPFAMiSSF54791 SSF54791, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A286XDJ3_CAVPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A286XDJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: June 5, 2019
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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