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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Persephonella hydrogeniphila
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN06265182_0354)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (SAMN06265182_0354)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11SubstrateUniRule annotation1
Binding sitei19ATPUniRule annotation1
Sitei19Transition state stabilizerUniRule annotation1
Binding sitei43SubstrateUniRule annotation1
Binding sitei77Substrate; via amide nitrogenUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei102ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 12ATPUniRule annotation2
Nucleotide bindingi92 – 94ATPUniRule annotation3
Nucleotide bindingi126 – 132ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processCoenzyme A biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
ORF Names:SAMN06265182_1730Imported
OrganismiPersephonella hydrogeniphilaImported
Taxonomic identifieri198703 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesHydrogenothermaceaePersephonella
Proteomesi
  • UP000219036 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homohexamer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 135CTP_transf_likeInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd02163 PPAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00151 PPAT_bact, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR001980 PPAT
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21342:SF1 PTHR21342:SF1, 1 hit
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
PRINTSiPR01020 LPSBIOSNTHSS
TIGRFAMsiTIGR01510 coaD_prev_kdtB, 1 hit
TIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

A0A285NMB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITKICVYPG TFDPVHYGHI DIVKRALNIF DYVVVAVAKN PRKKPLFTVE
60 70 80 90 100
ERVEMFRESV KDFGSERVII EPFDGLLVNF MKKYNTKIIV RGVRLFTDFE
110 120 130 140 150
YELQIAMTNY NLDKVETLFL MPSQELIHIS SSIVKDVASH HGDLSKMVHP
160
YVEKKLEERF I
Length:161
Mass (Da):18,799
Last modified:November 22, 2017 - v1
Checksum:i9D92A337C71ECE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
OBEI01000009 Genomic DNA Translation: SNZ10097.1

Similar proteinsi

Entry informationi

Entry nameiA0A285NMB4_9AQUI
AccessioniPrimary (citable) accession number: A0A285NMB4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: February 28, 2018
This is version 4 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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