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Entry version 10 (22 Apr 2020)
Sequence version 1 (22 Nov 2017)
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Protein
Submitted name:

Uncharacterized protein

Gene

BOX15_Mlig003760g3

Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi173 – 184PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BOX15_Mlig003760g3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesRhabditophoraMacrostomorphaMacrostomidaMacrostomidaeMacrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000215902 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 81EF-handInterPro annotationAdd BLAST36
Domaini82 – 117EF-handInterPro annotationAdd BLAST36
Domaini160 – 195EF-handInterPro annotationAdd BLAST36
Domaini196 – 231EF-handInterPro annotationAdd BLAST36
Domaini268 – 303EF-handInterPro annotationAdd BLAST36
Domaini378 – 413EF-handInterPro annotationAdd BLAST36
Domaini414 – 449EF-handInterPro annotationAdd BLAST36
Domaini485 – 520EF-handInterPro annotationAdd BLAST36
Domaini539 – 557EF-handInterPro annotationAdd BLAST19
Domaini615 – 650EF-handInterPro annotationAdd BLAST36
Domaini723 – 758EF-handInterPro annotationAdd BLAST36
Domaini759 – 794EF-handInterPro annotationAdd BLAST36
Domaini831 – 866EF-handInterPro annotationAdd BLAST36
Domaini867 – 902EF-handInterPro annotationAdd BLAST36
Domaini969 – 997EF-handInterPro annotationAdd BLAST29
Domaini1081 – 1116EF-handInterPro annotationAdd BLAST36
Domaini1229 – 1264EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1034 – 1066DisorderedSequence analysisAdd BLAST33
Regioni1160 – 1179DisorderedSequence analysisAdd BLAST20
Regioni1259 – 1314DisorderedSequence analysisAdd BLAST56
Regioni1436 – 1457DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili592 – 612Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1052 – 1066PolarSequence analysisAdd BLAST15
Compositional biasi1259 – 1275PolarSequence analysisAdd BLAST17
Compositional biasi1286 – 1314PolarSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom
IPR000048, IQ_motif_EF-hand-BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08976, EF-hand_11, 2 hits
PF13202, EF-hand_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 17 hits
PS50096, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A267FVL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSVSGVSQT NFAAQGRNGS IMPVASTSRT PQASAVDIAI SKHVKENFDE
60 70 80 90 100
LLSAFKVYDI ENNGSVTKGE LRRIIEINIT AINTADFGKV LKNATVNRNG
110 120 130 140 150
SVQYMTFLKF YKDLGQGASK EAEGEKRKQA DATGLNGKKP IDPNLNAGEI
160 170 180 190 200
EKLLKNAIES NLSSVLRGFR LFDYNRDRKI QFHELRKILE QYCFPMSNVQ
210 220 230 240 250
FEKLWNSIDY SKMGLIDYMD FLGRLGVAVP NAGSKNVGQR TERKKLQLGS
260 270 280 290 300
SGMNMDQLEV EYRRRLKEQH GLLKKACLVV DSKHSGLMPI KNFKAILDEF
310 320 330 340 350
VIAVSDQEFS KLMERFSVKA SHDIQWYGFL QKFVDPQSLS NGQTLPIRPS
360 370 380 390 400
HKANVVRGSH VEASVQDLIQ LLYNHILSAY SSLRNAFLQI DINRKGKITI
410 420 430 440 450
ADFRRLVQGF KFELSEVQIK EIMVQLDPEH TGFITYQKFL DIFEEKESAD
460 470 480 490 500
GHKWLVSTHK YNKDTKPPIL AWKTVEDLLH QKIVLRWKSF TAALKHYDST
510 520 530 540 550
GTGYINPTNL KKVLDKIAIP LSDEHYDSLL KRLSHKTADG KVNYLEFLAV
560 570 580 590 600
MQIDVYPGDV EGVSAQIASG NEARLQMRQS QHEKAMADIE THASLRTNMM
610 620 630 640 650
SLEEIIVRLR DRSSQTRQHI RDAFLQMDDA RKGFVSKAKF RLFLESHGIF
660 670 680 690 700
LSDENFSQLT RELEFGREGL DYMRFVKHFE GRDSELNPSY LPMQNHKYNP
710 720 730 740 750
VRGDEFGMSA PAVENKLRSK IRENFTTLRE AFHKMDSDGR GYLTKQDFRR
760 770 780 790 800
LLDQLMCLTN DAEFNKLCNK LGIDDDCKLS YRDFLGKFQE KDDLATGHKW
810 820 830 840 850
LVSNHRYNEL GDIKPKTAAE VHQLMAEKVH QNYKDIARAF CHIDYLGRGY
860 870 880 890 900
ITKREFKELL VRLNVTMDQE EFKKLWAYYD TANRNAITHD AFLKRVGVAS
910 920 930 940 950
AFSSGDGQGT SAKIIQNSAE YIAVHLEGQE NRQENLVFNQ AVLTVGLDAD
960 970 980 990 1000
ALFIILQKRI RDFFPTTYAA FRALDGKEKG YLSQEDFRIA VHQMHLFVRD
1010 1020 1030 1040 1050
ESFAELMRRI GLSQPIAQMT YEAFCLAFDE KFSGPRESQR PKTAGPMLDG
1060 1070 1080 1090 1100
ARGGQQQQQQ QPQQRQDAKA FLKRLRASVV KDGEILEKVF RSMDTKQESR
1110 1120 1130 1140 1150
IGASDFRRVV DGFCFKLTDA QFKEVVKGLL SQGDQVDYYR FLANFSQTQE
1160 1170 1180 1190 1200
AAERREWMEA ANGGGGGAGG SAEDGESLSQ QEVEARVSEF VSARPHLLAQ
1210 1220 1230 1240 1250
AFAEADYAQL GVLAKTDFRD ILFRLVMRMS NEQFDQLMTR VPTNEYGNVD
1260 1270 1280 1290 1300
YKEFLSRFAS AEQPQQQQQQ PTAGGDARPD SPISLTPPAS ADQAQQQQQQ
1310 1320 1330 1340 1350
PQQPTLSLET EAEAQLRRAM SQSWKTLFSR FKLLDQATPD KPKQIHVDDF
1360 1370 1380 1390 1400
CAVLRSSGAV DLAPSQVAPI LRRFGLRGDG YFRYQDCMRA FVSGDGPSSF
1410 1420 1430 1440 1450
GIGARASARG GPETAQIVRR KMERARISFV APTAASAAPA AEPPATVRSG

GGVGGGG
Length:1,457
Mass (Da):164,642
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9BF30E965B46CA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1457Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NIVC01000773 Genomic DNA Translation: PAA77002.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NIVC01000773 Genomic DNA Translation: PAA77002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00051, EFh, 3 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom
IPR000048, IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF08976, EF-hand_11, 2 hits
PF13202, EF-hand_5, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 12 hits
SUPFAMiSSF47473, SSF47473, 7 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 17 hits
PS50096, IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A267FVL1_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A267FVL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: April 22, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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