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Entry version 10 (22 Apr 2020)
Sequence version 1 (22 Nov 2017)
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Protein

CARD domain-containing protein

Gene

BOX15_Mlig026612g2

Organism
Macrostomum lignano
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CARD domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BOX15_Mlig026612g2Imported, BOX15_Mlig026612g3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacrostomum lignanoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282301 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesRhabditophoraMacrostomorphaMacrostomidaMacrostomidaeMacrostomum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000215902 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini289 – 378CARDInterPro annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni635 – 703DisorderedSequence analysisAdd BLAST69
Regioni1264 – 1283DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili216 – 240Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi661 – 676PolyampholyteSequence analysisAdd BLAST16
Compositional biasi677 – 703PolarSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR041249, HEPN_DZIP3
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit
PF18738, HEPN_DZIP3, 1 hit
PF05729, NACHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A267DGN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEVRRMTLA ARPKNQVVFG VVDNTPKLQL DMTDERSVEN LSRVCHFLMR
60 70 80 90 100
EGKACLRSLF DSKHPTDELT EHLASPDIHR TLRRLKIKDM LTEDDWQTLY
110 120 130 140 150
PKEKSSVSAD NYDLRLLLLL VKYTCDVTKP QPNGWMGDPE PRDDSQGAAL
160 170 180 190 200
QRLLGIQREL ASLQTLKASA ANRLFSRIAE QLQRLGHSGA ADCMNAYKQD
210 220 230 240 250
TSMDETESRF ILGEFLVWYR QEVSQLKREI ENQERKKKRE EIPILQKRLK
260 270 280 290 300
TRDLDTSETK KRQSVVGKAT MDMSDKSRCQ RWAHIKTGMV LAERLILDKY
310 320 330 340 350
YEQLLNDVKA DTVVEHLMNK EIITQDESTE IFSTLRNNEQ MSTLIDFLVP
360 370 380 390 400
KSGNVLDEFV ESLKPKNEQV YQQMHQDYQA AKADILANKP QGLPYCNNIL
410 420 430 440 450
RERYSTAYAK WNPIPWYTKV ETDIAEFYCQ QQLLNLNGKS VNAFQVFDYK
460 470 480 490 500
EGEKDPHTVV IEGDPGTGKS TLAKYMAYKW SLDENVFGRP FQLLILLDLK
510 520 530 540 550
VTAPTVKVMM MEQLFGGDCK LAEREIWEVM NMHQASTLLI IDGYEDNLND
560 570 580 590 600
EMKSLLFENI MPELHILVFS QTNFTVRLMH RYQRKVILTG FAKSQAEEYV
610 620 630 640 650
QKYVKLAKKP WEHFSSFLNK LVVAKKSTEL QKLLDAAKKS QEPQRRRGSS
660 670 680 690 700
ESATSVTSAK PRDERPLERE NTDKVSTKLS RSSSKGQGND QQQQQDSNGE
710 720 730 740 750
NSNQSKIASL RHYSQVPLYC SFFCLLTDMR MSIDLNSPTT IVEQFVSCIK
760 770 780 790 800
LKLIEREKES RFEANRAYAM LSERAMDTIK KGSATFILAK EDHMMTKFGL
810 820 830 840 850
IQLATNLTAE DNQRYMFGNR LIQEYLAAKN LDTSGTDEAS RFFQNMSMTP
860 870 880 890 900
ISYNVVVFYC SIRKSDNDTP ATRELFAKIL QYNKRRGKAS RMKMPAATSP
910 920 930 940 950
EDSQLVEGKI MDYQLSLECV AVMDMARRDL GKKIVESLPE RFTVKHEGII
960 970 980 990 1000
PRLSLTGLSK MIKFNHTTIQ EVDLRLDLLA KETLEAYKSL ATAMKTNVHI
1010 1020 1030 1040 1050
KTLRIYWTEK DLMADFLQTV CCPEPEDPAN STGQMEIRRK KPDQTGFHLK
1060 1070 1080 1090 1100
NLECIDESGK KLDQLSPKML NNMREACSNM TKLETFAFQN CHHMSLVGSI
1110 1120 1130 1140 1150
IKNLPTKFAD NLRILDFSGC QMSIVASQDL NGKLMESKSL EGLILANLKI
1160 1170 1180 1190 1200
DAMAFNTFIA AFSSNRTIVL LDLSGIRLDN VCFFSLSEAL KINNKLEKLF
1210 1220 1230 1240 1250
LRQVPMDTRA CKEVARILKI NKMLKLLTVT QEIVSEEGRR VLGEESQTET
1260 1270 1280
RKNRAVVDGI GVEYRQRPTN ERANTKRNPL SVK
Length:1,283
Mass (Da):147,145
Last modified:November 22, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F40C80D0EB8520E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NIVC01004146 Genomic DNA Translation: PAA48443.1
NIVC01003379 Genomic DNA Translation: PAA51667.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NIVC01004146 Genomic DNA Translation: PAA48443.1
NIVC01003379 Genomic DNA Translation: PAA51667.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR041249, HEPN_DZIP3
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PF18738, HEPN_DZIP3, 1 hit
PF05729, NACHT, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A267DGN7_9PLAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A267DGN7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: April 22, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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