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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Thiomonas sp. 15-66-11
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
ORF Names:B7X46_00045Imported
OrganismiThiomonas sp. 15-66-11Imported
Taxonomic identifieri1970452 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesThiomonas

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei713N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A259PBN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMQTEPTLT ELEDTRAFQR RHIGPSAAEQ AHMLHALGQP DLDALLRDVI
60 70 80 90 100
PADIRRRSSF SLPAASSEVQ ALAELRRIAA QNRVMRSFIG QGYANAHMPG
110 120 130 140 150
VIQRNVLENP AWYTAYTPYQ PEISQGRLEA LINFQTMVTD LTALDVANAS
160 170 180 190 200
MLDEATAAAE AMTLALRAGK SASRSMFVAD DVLPQTLEVI RTRAAPIGVQ
210 220 230 240 250
VVVGPAAQAA QADYFAVLLQ YPGVDGGVHD HRTLIAEVKA RGGLVIMAAD
260 270 280 290 300
ILALTLLVPP GELGADIAVG NTQRFGLPLG FGGPHAAYMA VRDALKRQMP
310 320 330 340 350
GRLVGVSVDT HGQPAYRLAL QTREQHIRRE KATSNICTAQ VLPAVLASMY
360 370 380 390 400
AVYHGPQGLR RIARRVHAYT AILADALQAQ GWELQHARFF DTLTVLSGAH
410 420 430 440 450
TARLHAAAVD AGINLRRVDD ARVGVTLDET VDRNDLLALL GVFADARGAL
460 470 480 490 500
KPSGSVFDAY AKGVLPRYAA ELVRTSGFLT HPVFHRYQSE TEMLRYLRRL
510 520 530 540 550
ADRDIALDRA MIPLGSCTMK LNATSEMVPI TWPEFAAIHP YAPADQTQGY
560 570 580 590 600
AHLAADLEQW LAQATGYDAV SLQPNAGSQG EYAGLLAIHA WHASRGDARR
610 620 630 640 650
DVCLIPSSAH GTNPASAQMA GMQVVVVACD AQGSVDLDDL RAKAAQHADR
660 670 680 690 700
LAACMITYPS THGVFEPRVR EICDVVHAHG GQVYVDGANM NAMVGLASPP
710 720 730 740 750
EFGADVSHLN LHKTFCIPHG GGGPGVGPVA VRAHLAPFLP GHAASGRAGG
760 770 780 790 800
PVGAVSAAAL GNASVLPITW MYIRMMGADG LTAASAVSIL GANYLAKRLA
810 820 830 840 850
PYYPVLYTGE GGFVAHECIL DLRGLKDASG ISNEDVAKRL MDYGFHAPTM
860 870 880 890 900
SFPVPGTLMI EPTESESLAE LDRFVEAMIA IRAEIGQVEQ GSWPREDNPL
910 920 930 940 950
KAAPFTAAAL LGADWPHAYS REQAAFPVPA LRAHKYWVPV GRIDNVWGDR
960
NLQCACIPVA AYAQEPEVA
Length:969
Mass (Da):103,821
Last modified:December 20, 2017 - v1
Checksum:i13FB4A266A4F4EF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NCKA01000001 Genomic DNA Translation: OZB46261.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NCKA01000001 Genomic DNA Translation: OZB46261.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A259PBN7_9BURK
AccessioniPrimary (citable) accession number: A0A259PBN7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 20, 2017
Last sequence update: December 20, 2017
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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