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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Clavibacter michiganensis subsp. michiganensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd), dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Important for bifunctional activityUniRule annotation2
Binding sitei119dCTPUniRule annotation1
Active sitei129Proton donor/acceptorUniRule annotation1
Binding sitei148dCTPUniRule annotation1
Binding sitei162dCTPUniRule annotation1
Binding sitei174dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106dCTP bindingUniRule annotation6
Nucleotide bindingi127 – 129dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processNucleotide metabolismUniRule annotationSAAS annotation
LigandNucleotide-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotationImported
ORF Names:CMMCAS07_05355Imported
OrganismiClavibacter michiganensis subsp. michiganensisImported
Taxonomic identifieri33013 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000195062 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 177dUTPaseInterPro annotationAdd BLAST108

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A0A251XMB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSDRDITA ELDAGRVALD PYDPGMLQPA SIDVRIDRFF RLFDNHKYPY
60 70 80 90 100
IDPAEDQPEL TRLIESKPGE PFILHPGEFV LGSTYELVTL PDDVAARLEG
110 120 130 140 150
KSSLGRLGLL THSTAGFIDP GFSGHVTLEL SNVATLPIKL WPGMKIGQLC
160 170 180 190 200
FFRLSSPAEK PYGSGEYASR YQGQRGPTAS RSHLNFVHTD VTVTDAGQPG

E
Length:201
Mass (Da):22,072
Last modified:November 22, 2017 - v1
Checksum:i87A6F9EC72F2AD40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MDHH01000001 Genomic DNA Translation: OUE04353.1

Similar proteinsi

Entry informationi

Entry nameiA0A251XMB8_CLAMM
AccessioniPrimary (citable) accession number: A0A251XMB8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: June 20, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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