Cyclin-dependent kinase inhibitor 1B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cyclin binding Source: Ensembl
• cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl
• kinase activity Source: UniProtKB-KW
• protein-containing complex binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl

GO - Biological processⁱ

• autophagic cell death Source: Ensembl
• cellular response to antibiotic Source: Ensembl
• cellular response to lithium ion Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• G1/S transition of mitotic cell cycle Source: Ensembl
• heart development Source: Ensembl
• inner ear development Source: Ensembl
• mitotic cell cycle arrest Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of cardiac muscle tissue regeneration Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of cellular component movement Source: Ensembl
• negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
• negative regulation of transcription, DNA-templated Source: Ensembl
• negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
• Notch signaling pathway Source: Ensembl
• placenta development Source: Ensembl
• positive regulation of cell death Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of microtubule polymerization Source: Ensembl
• positive regulation of protein catabolic process Source: Ensembl
• potassium ion transport Source: Ensembl
• regulation of cell cycle G1/S phase transition Source: Ensembl
• regulation of exit from mitosis Source: Ensembl
• regulation of lens fiber cell differentiation Source: Ensembl
• sensory perception of sound Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cyclin binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVNHEE LTRDLEKHRR 
        60         70         80         90        100
DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK 
       110        120        130        140        150
VPAQEGQDVS GSRQAVPLVG SQANSEDTHL VDQKTDPSAS QTGLAEQCAG 
       160        170        180        190 
IRKRPATDES STQNKRANRT EENVSDGSAN AGSVVEQTPK KPGLRRRQT  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ