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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (A8G17_29440), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (A8G17_29440), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional purine biosynthesis protein PurH (purH), Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/inosine monophosphate cyclohydrolase (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported, Multifunctional enzymeUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotationImported
Biological processPurine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotationImported
ORF Names:BMR26_22945Imported, CDL37_18310Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000224973 Componenti: Unassembled WGS sequence
  • UP000214591 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-acetyllysineUniRule annotation1

Keywords - PTMi

AcetylationUniRule annotation

Structurei

3D structure databases

SMRiA0A229AHX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 132MGSInterPro annotationAdd BLAST114

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A229AHX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQRRPVRRA LLSVSDKAGI VEFAQALSAR GVELLSTGGT ARLLAEKGLP
60 70 80 90 100
VTEVSDYTGF PEMMDGRVKT LHPKVHGGIL GRRGQDDTIM EEHQIQPIDM
110 120 130 140 150
VVVNLYPFAQ TVAREGCSLE DAVENIDIGG PTMVRSAAKN HKDVAIVVKS
160 170 180 190 200
SDYDAIIKEI DANEGSLTLE TRFDLAIKAF EHTAAYDSMI ANYFGSMVPA
210 220 230 240 250
YHGESKEAAG RFPRTLNLNF IKKQDMRYGE NSHQQAAFYI EENVKEASVA
260 270 280 290 300
TATQVQGKAL SYNNIADTDA ALECVKEFAE PACVIVKHAN PCGVAIGNSI
310 320 330 340 350
LDAYDRAYKT DPTSAFGGII AFNRELDAET AQAIISRQFV EVIIAPSASE
360 370 380 390 400
EALKITAAKQ NVRVLTCGQW GERVPGLDFK RVNGGLLVQD RDLGMVGAEE
410 420 430 440 450
LRVVTKRQPS EQELRDALFC WKVAKFVKSN AIVYAKNNMT IGIGAGQMSR
460 470 480 490 500
VYSAKIAGIK AADEGLEVKG SSMASDAFFP FRDGIDAAAA AGVTCVIQPG
510 520
GSIRDDEVIA AADEHGIAML FTDMRHFRH
Length:529
Mass (Da):57,370
Last modified:October 25, 2017 - v1
Checksum:i55DD409EAC77ACA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NIIS01000060 Genomic DNA Translation: OXK50264.1
MPIE01000054 Genomic DNA Translation: PGF93903.1
RefSeqiWP_001187583.1, NZ_PVQI01000075.1

Similar proteinsi

Entry informationi

Entry nameiA0A229AHX7_ECOLX
AccessioniPrimary (citable) accession number: A0A229AHX7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: July 18, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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