Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetylornithine deacetylase

Gene

argE

Organism
Shigella flexneri 2a str. 301
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Co2+SAAS annotation
  • glutathioneUniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Cobalt or zinc 1UniRule annotation1
Active sitei95UniRule annotation1
Metal bindingi125Cobalt or zinc 1UniRule annotation1
Metal bindingi125Cobalt or zinc 2UniRule annotation1
Active sitei157UniRule annotation1
Metal bindingi158Cobalt or zinc 2UniRule annotation1
Metal bindingi182Cobalt or zinc 1UniRule annotation1
Metal bindingi368Cobalt or zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandCobaltUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
ORF Names:SF301_2360Imported
OrganismiShigella flexneri 2a str. 301Imported
Taxonomic identifieri198214 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000198358 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 301M20_dimerInterPro annotationAdd BLAST111

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A226KGU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDTIMTRG VSTMKNKLPP FIEIYRALIA TPSISATEEA LDQSNADLIT
60 70 80 90 100
LLADWFKDLG FNVEVQPVPG TRNKFNMLAS YGQGAGGLLL AGHTDTVPFD
110 120 130 140 150
DGRWTRDPFT LTEHDGKLYG LGTADMKGFF AFILDALRDV DVTKLKKPLY
160 170 180 190 200
ILATADEETS MAGARYFAET TALRPDCAII GEPTSLQPVR AHKGHISNAI
210 220 230 240 250
RIQGQSGHSS DPARGINAIE LMHDAIGHIL QLRDNLKERY HYEAFTVPYP
260 270 280 290 300
TLNLGHIHGG DASNRICACC ELHMDIRPQP GMTLNELNGL LNDALAPVSE
310 320 330 340 350
RWPGRLTVDE LHPPIPGYEC PPNHQLVEVV EKLLGAKTEV VNYCTEAPFI
360 370 380 390
QTLCPTLVLG PGSINQAHQP DEYLETRFIK PTRELIIQVI HHFCWH
Length:396
Mass (Da):43,859
Last modified:October 25, 2017 - v1
Checksum:iDF39999229F48480
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NEDR01000001 Genomic DNA Translation: OXB30163.1

Entry informationi

Entry nameiA0A226KGU6_SHIFL
AccessioniPrimary (citable) accession number: A0A226KGU6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: December 20, 2017
This is version 3 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health