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Protein

Hemagglutinin-esterase-fusion glycoprotein

Gene

HE

Organism
Influenza C virus (C/Minnesota/20/2015)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.UniRule annotation

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutininUniRule annotation, HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-esterase-fusion glycoproteinUniRule annotation (EC:3.1.1.53UniRule annotation)
Gene namesi
Name:HEUniRule annotationImported
OrganismiInfluenza C virus (C/Minnesota/20/2015)Imported
Taxonomic identifieri2025143 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeGammainfluenzavirus

Subcellular locationi

  • Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei625 – 652HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host membrane, Membrane, VirionUniRule annotation

PTM / Processingi

Post-translational modificationi

In natural infection, inactive HEF is matured into HEF1 and HEF2 outside the cell by one or more trypsin-like, arginine-specific endoprotease.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HEF1-HEF2.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 419Hema_esteraseInterPro annotationAdd BLAST381
Domaini151 – 304Hema_HEFGInterPro annotationAdd BLAST154
Domaini447 – 621Hema_stalkInterPro annotationAdd BLAST175

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili509 – 536Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR008980 Capsid_hemagglutn
IPR007142 Hemagglutn-estrase_core
IPR003860 Hemagglutn-estrase_hemagglutn
IPR014831 Hemagglutn_stalk_influenz-C
PfamiView protein in Pfam
PF03996 Hema_esterase, 1 hit
PF02710 Hema_HEFG, 1 hit
PF08720 Hema_stalk, 1 hit
SUPFAMiSSF49818 SSF49818, 1 hit

Sequencei

Sequence statusi: Complete.

A0A223FLE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFSLLLVFG LTEAEKIKIC LQKQVNSSFS LHNGFGGNLY ATEEKRMFEL
60 70 80 90 100
VKPKAGASVL NQSTWIGFGD SRTDKSNSAF PRSADVSEKT ADKFRSLSGG
110 120 130 140 150
SLMLSMFGPP GKVDYLYQGC GKHKVFYEGV NWSPHAAIDC YRKNWTDIKL
160 170 180 190 200
NFQKNIYELA SQSHCLSLVN ALDKTIPLRV TKGVAGNCND SFLKNPALYT
210 220 230 240 250
QEVNPSENKC GEENLASFTL PTRFGTYDCK IHLVASCYFI YDSKEVYNKR
260 270 280 290 300
GCGNYFQVIY DSSGKVVGGL DNRVSPYTGN SGDTPTMQCD MLQLKPGRYS
310 320 330 340 350
VRSSPRFLLM PERSYCFDMK EKGPVTAVQS IWGKGRKSDY AVDQACLSTP
360 370 380 390 400
GCMLIQKQKP YVGEADAHHG DQEMRELLSG LDYEARCVSQ SGWVNETSPF
410 420 430 440 450
AKEYLLPPKF GRCPLAAKEE SIPKIPDGLL IPTSGTDTTV TKPKSRIFGI
460 470 480 490 500
DDLIIGLLFV AIVEAGIGGY LLGSRKESGG GVTKESAEKG FEKIGNDIQI
510 520 530 540 550
LRSSTNTAIE KLNDRISHDE QAIRDLTLEI ENARSEALLG ELGIIRALLV
560 570 580 590 600
GNISIGLQES LWELASEITN RAGDLAVEVS PGCWIIDNNI CDQSCQDFIF
610 620 630 640 650
KFNETAPVPT IPPLDTKIDL QSDPFYWGSS LGLAITAAIS LAALVISGIA

ICRTK
Length:655
Mass (Da):71,909
Last modified:October 25, 2017 - v1
Checksum:i526A68542F568277
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY239452 Viral cRNA Translation: AST08249.1

Similar proteinsi

Entry informationi

Entry nameiA0A223FLE3_9ORTO
AccessioniPrimary (citable) accession number: A0A223FLE3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: April 25, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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