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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Shewanella bicestrii
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotationSAAS annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotationSAAS annotation

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (deoA)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotationSAAS annotation (EC:2.4.2.4UniRule annotationSAAS annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotationImported
ORF Names:CF168_15525Imported
OrganismiShewanella bicestriiImported
Taxonomic identifieri2018305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000198367 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A220UQE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 424PYNP_CInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00758

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_01628 Thymid_phosp, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
IPR013465 Thymidine_Pase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02643 T_phosphoryl, 1 hit
TIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A220UQE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAQEIIRK KRNGLALSTE EIQFFVKGIT TNAVSEGQIA ALGMAVYFND
60 70 80 90 100
MNMDERIALT TAMRDSGTVL NWQSLGLNGP VIDKHSTGGV GDVISLMLGP
110 120 130 140 150
MAAACGGYVP MISGRGLGHT GGTLDKFDAI PGYQTEPSSE LFRKVVKDVG
160 170 180 190 200
VAIIGQTGDL VPADKRFYSI RDNTATVESI SLITASILSK KLACSLDALA
210 220 230 240 250
MDVKVGSGAF MPTYEASEEL ARSIAAVANG AGTKTTALLT DMNQVLASCA
260 270 280 290 300
GNAVEVKEAI DFLTGAYRNP RLYAVTMGLC AEMLLLGGLA TDEADARAKL
310 320 330 340 350
NRVLDNGRAA EIFGKMVSGL GGPVDFVENY SKYLPQSQII RPVFADTQGY
360 370 380 390 400
AHSMDTRELG LAVVTLGGGR RKPGDALDYS VGLTQVCALG DKIDASTPIA
410 420 430 440
VIHAQSEDAF AQAEEAVKKA IRIDEVAPEK TPEIYAYIRA ADL
Length:443
Mass (Da):46,864
Last modified:November 22, 2017 - v1
Checksum:iC5376AF555F29CE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP022358 Genomic DNA Translation: ASK70151.1
RefSeqiWP_011625502.1, NZ_CP022358.1

Genome annotation databases

KEGGisbj:CF168_15525

Similar proteinsi

Entry informationi

Entry nameiA0A220UQE1_9GAMM
AccessioniPrimary (citable) accession number: A0A220UQE1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: November 22, 2017
Last modified: March 28, 2018
This is version 5 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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