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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Thermococcus pacificus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Activity regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
ORF Names:A3L08_03845Imported
OrganismiThermococcus pacificusImported
Taxonomic identifieri71998 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000197418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, ProteasomeUniRule annotationImported

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 32PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 259Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03432

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A218P6Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFVPPQAGY DRAITVFSPD GRLFQVNYAR EAVKRGATAV GVKWKDGVVL
60 70 80 90 100
AVEKRITSKL IEPSSYEKIF QIDDHIAAAP SGIIADARVL VDRARLEAQV
110 120 130 140 150
YRLTYGEPVP LTVLVKKICD LKQAHTQYGG VRPFGAALLM AGVNDKPELY
160 170 180 190 200
ETDPSGAYFE WKAVAIGSGR NVAMAIFEEH YTDDIDREGA VKLAILALAK
210 220 230 240 250
TLEEPSAEGI EVAYITTEDK RWKKLSKEDI EKYLAEILEE VKEEEVEERE
260
EDYSELDQNY
Length:260
Mass (Da):29,076
Last modified:September 27, 2017 - v1
Checksum:i4C6DC323FBF99D58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP015102 Genomic DNA Translation: ASJ06521.1

Genome annotation databases

KEGGitpaf:A3L08_03845

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP015102 Genomic DNA Translation: ASJ06521.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGitpaf:A3L08_03845

Phylogenomic databases

KOiK03432

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A218P6Y2_9EURY
AccessioniPrimary (citable) accession number: A0A218P6Y2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 27, 2017
Last sequence update: September 27, 2017
Last modified: September 12, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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