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UniProtKB - A0A210V7E1 (A0A210V7E1_KLEPN)

Entry version 9 (31 Jul 2019)
Sequence version 1 (25 Oct 2017)
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Protein

Malate dehydrogenase (quinone)

Gene

B4U21_19905

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADSAAS annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).SAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Malate dehydrogenase (quinone) (DM062_14410), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_4), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (DM059_21065), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (DM062_23220), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_3), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (B4U25_23685), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (DM062_23225), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (CSC88_37850), Malate dehydrogenase (quinone) (B4U21_19900), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_1), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_3), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (mqo_5), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_4), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_4), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_2), Malate dehydrogenase (quinone) (mqo), Malate dehydrogenase (quinone) (B4U21_12005), Malate dehydrogenase (quinone) (mqo_3), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (CWN54_35015), Probable malate:quinone oxidoreductase (mqo_1), Malate dehydrogenase (quinone) (B4U30_22540), Malate dehydrogenase (quinone) (B4U21_19905), Malate dehydrogenase (quinone) (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_1), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo_2), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo), Malate dehydrogenase (quinone) (mqo_5), Probable malate:quinone oxidoreductase (mqo), Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseSAAS annotation
Biological processTricarboxylic acid cycleSAAS annotation
LigandFADSAAS annotation, Flavoprotein

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00223;UER01008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malate dehydrogenase (quinone)SAAS annotation (EC:1.1.5.4SAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:B4U21_19905Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri573 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Klebsiella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000196863 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MQO family.SAAS annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06039 Mqo, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A210V7E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKKMAVPRS QAVGPNSTRT NTRHEQETDV LLIGGGIMSA TLGTWLQELE 
        60         70         80         90        100
PDWSITMVEQ MSSVAEESSN GWNNAGTGHA ALMELNYTPQ TANGINIDKA 
       110        120        130        140        150
VDINEAFHIS RQFWAHQVTR GVLNKPKSFI NSVPHMSFVW GEDNVNFLRA 
       160        170        180        190        200
RYAALQQSEL FRGIRYSEDH QQIKAWAPLV MEGRDPLQKV AATRSEVGTD 
       210        220 
VNYGEITRQL IAGLQKHDNF SLQLGTVV
Length:228
Mass (Da):25,422
Last modified:October 25, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E1750E30AB3F367
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei228Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
NBSD01001533 Genomic DNA Translation: OWG05882.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBSD01001533 Genomic DNA Translation: OWG05882.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Enzyme and pathway databases

UniPathwayiUPA00223;UER01008

Family and domain databases

InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A210V7E1_KLEPN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A210V7E1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: July 31, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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