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Protein

Homoserine O-acetyltransferase

Gene

metX

Organism
Mycobacterium paratuberculosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metX)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei157NucleophileUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Active sitei320UniRule annotation1
Active sitei350UniRule annotation1
Binding sitei351SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Short name:
HATUniRule annotation
Alternative name(s):
Homoserine transacetylaseUniRule annotation
Short name:
HTAUniRule annotation
Gene namesi
Name:metXImported
Synonyms:metXAUniRule annotation
ORF Names:B0172_03716Imported, B0173_04218Imported
OrganismiMycobacterium paratuberculosisImported
Taxonomic identifieri1770 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000196522 Componenti: Unassembled WGS sequence
  • UP000196305 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiA0A200GPZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 356AB hydrolase-1InterPro annotationAdd BLAST305

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00641

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
HAMAPiMF_00296 MetX_acyltransf, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR008220 HAT_MetX-like
PANTHERiPTHR32268 PTHR32268, 1 hit
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000443 Homoser_Ac_trans, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR01392 homoserO_Ac_trn, 1 hit

Sequencei

Sequence statusi: Complete.

A0A200GPZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPDVPTQT LPDEGEIGFV HIGSLTTEAG AVIDDVHIAV QRWGELSPTR
60 70 80 90 100
DNVVVVLHAL TGDSHVTGPA GPGHPTGGWW DEMVGPGAPI DTDRWCAVAT
110 120 130 140 150
NVLGGCRGST GPSSRTRDGK PWGSRFPRIS IRDQVEADIA ALAALGIDEV
160 170 180 190 200
AAVVGGSMGG ARALEWIVGH PSRVRAGLLL AVGARATADQ IGTQCTQIAA
210 220 230 240 250
IKSDPNWQGG DYHDTGRTPD AGLAIARRFA HLTYRGEVEL DTRFGNDAQL
260 270 280 290 300
DEDPANSGRY AVQSYLEYQG VKLVERFDAG SYVVLTEALN SHDVGRARGG
310 320 330 340 350
VRKALRSCPV PVVVGGITSD RLYPLRLQQE LAEQLPGCAE LQVVDSICGH
360 370 380 390
DGFLVESEAV GEMIRKTLLL AGSQSAGPGG AGPGSRKGTT RR
Length:392
Mass (Da):41,244
Last modified:October 25, 2017 - v1
Checksum:iE63E8BA1AED0A911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MWPB01000023 Genomic DNA Translation: OUZ02286.1
MWQD01000027 Genomic DNA Translation: OVF01299.1
RefSeqiWP_003874462.1, NZ_NKRI01000005.1

Genome annotation databases

GeneIDi2720909
KEGGimavi:RC58_01520
mavu:RE97_01530

Similar proteinsi

Entry informationi

Entry nameiA0A200GPZ6_MYCPC
AccessioniPrimary (citable) accession number: A0A200GPZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 25, 2017
Last sequence update: October 25, 2017
Last modified: June 20, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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