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Entry version 27 (02 Jun 2021)
Sequence version 1 (30 Aug 2017)
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Protein
Submitted name:

MutL homolog 3

Gene

Mlh3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damageARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MutL homolog 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mlh3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1353455, Mlh3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
336539

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A1Y7VMP7, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1Y7VMP7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00800000124176

Database of Orthologous Groups

More...
OrthoDBi
735423at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.20, 1 hit
3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014762, DNA_mismatch_repair_CS
IPR013507, DNA_mismatch_S5_2-like
IPR036890, HATPase_C_sf
IPR028830, Mlh3
IPR038973, MutL/Mlh/Pms
IPR014790, MutL_C
IPR042120, MutL_C_dimsub
IPR042121, MutL_C_regsub
IPR037198, MutL_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR10073, PTHR10073, 1 hit
PTHR10073:SF47, PTHR10073:SF47, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01119, DNA_mis_repair, 1 hit
PF08676, MutL_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01340, DNA_mis_repair, 1 hit
SM00853, MutL_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118116, SSF118116, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00058, DNA_MISMATCH_REPAIR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A1Y7VMP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRCLSDDVK TKLRSGLAIS SLGQCVEELT LNSIDAEATC VAIRVNMETF
60 70 80 90 100
QVQVIDNGLG MAGDDVEKVG NRYFTSKCHS VRDLENPAFY GFRGEALASI
110 120 130 140 150
ADMAGAVEIS SKKNTTLKTF VKMFQNGKAL ATHEADLTRP SVGTTVTVYN
160 170 180 190 200
LFYQFPVRRK SMDPRLEFEK VRQRVEALSL MHPSISFSLR NDVSGSMVLQ
210 220 230 240 250
LPKTKDICSR FCQIYGLGKS QKLREIRFKY KEFEFSGYIS SEAHYNKNMQ
260 270 280 290 300
FLFVNRRLVL RTKLHKLIDF LLRKESIICR PKNGSASRQM NSSPRHRSAS
310 320 330 340 350
ELHGIYVINV QCPFCEYDVC IEPAKTLIEF QSWDTVLICI QEGVKRFLKQ
360 370 380 390 400
EKLFVELSGE DIKEFNEDNG FSLFGTTLQT HVSTHEKCDQ SSFREACNKI
410 420 430 440 450
LDSYEMFNLQ SKAVKRIATL ENKTRQNPGD SETIRKKTVG SLYTDASDGP
460 470 480 490 500
CYSKSVESVL QDSNNSAYLE PRVSEEEVAK TSHSGENEKW KKSFLENKTS
510 520 530 540 550
GRIHETSPKM FSSPIQMHHL LEEREADLEM QTISSTVNVM AANIPQNNDI
560 570 580 590 600
PSQLEKWKDA PEVGCQPLPF ETTLLRVRGT QRKKERRKKE PSSRGRVNVF
610 620 630 640 650
SYGQVKLCST GFITHVVQSE HAKSTETEHS FKNYARPGPV SAQETFGKRT
660 670 680 690 700
HHAIETPDSS DLTSTLSKES SQPPNKRFCR TNTGYGTENK PVATDDNLAL
710 720 730 740 750
FQESCKESHT DRLLPDASSF PWCRYVSDGC RKIDKRGSFK QVVRRKLSLR
760 770 780 790 800
SQVGSLEKFK RQYGKVSSSL DTEKDNNTEV RTHLDPQNEP DVLLKDKSHL
810 820 830 840 850
DMSDGCEITT VEHSETCQPL SPILYPEKIL FSKEDRLEQM PHLRESPITL
860 870 880 890 900
EELSHCNRKA DVEKSAASLA SKLSKLKDSE KEMQTVGMTG HTSELPDSNP
910 920 930 940 950
SWKDNSQCTR LDLDFCELLK NKLEKIESDM LPMADSATED GPINKNSELH
960 970 980 990 1000
PNNTTDDTEK PETPLLFPCN DSKISRDSDV LIRTSEQPTG NPDSVGKVIM
1010 1020 1030 1040 1050
SQVEDGIGSQ GGVCPQGDES KARSCSKNEP NAHCMDWQQH FDVTLGRMVY
1060 1070 1080 1090 1100
INRMTGLSTF VAPTDDLHTA CTKDLTTVAV DVLLGNGAQY RCHPFRSDLV
1110 1120 1130 1140 1150
LPFLPRAQEE RTMLRHNSNA VDAAAAAVSE PLQSLFSEWS NPVFARYPEV
1160 1170 1180 1190 1200
AVDVSSGQAE SLAVKIHNVL YPYRFTKEMI HSVKVLQQVD NKFIACLMST
1210 1220 1230 1240 1250
RMDEDGRTGG NLLVLVDQHA AHERIRLEQL ITDSYEKQDP QSAGRKKLLS
1260 1270 1280 1290 1300
STIIPPLAIT VSEEQRRLLR SYHKHLEDLG LELLFPDASD SLILVGKVPL
1310 1320 1330 1340 1350
CFVEREASEL RRGRSTVTKS IVEELIREQV ELLQTTGGIQ GTLPLTVQKV
1360 1370 1380 1390 1400
LASQACHGAI KFNDRLSLEE SCRLIEALSL SQLPFQCAHG RPSMLPLADL
1410 1420 1430 1440
DHLEQEKQVK PNLAKLRKMV RAWHLFGKTE QNLQQPIRPC EPP
Length:1,443
Mass (Da):162,524
Last modified:August 30, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6622642A3D2A3A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68FG1Q68FG1_MOUSE
MutL homolog 3
Mlh3
1,411Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJX4A0A1Y7VJX4_MOUSE
MutL homolog 3
Mlh3
197Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_006515766.1, XM_006515703.3
XP_006515767.1, XM_006515704.3
XP_006515769.1, XM_006515706.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000220854; ENSMUSP00000152840; ENSMUSG00000021245

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217716

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006515766.1, XM_006515703.3
XP_006515767.1, XM_006515704.3
XP_006515769.1, XM_006515706.3

3D structure databases

SMRiA0A1Y7VMP7
ModBaseiSearch...

Proteomic databases

ProteomicsDBi336539

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25763, 152 antibodies

The DNASU plasmid repository

More...
DNASUi
217716

Genome annotation databases

EnsembliENSMUST00000220854; ENSMUSP00000152840; ENSMUSG00000021245
GeneIDi217716

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27030
MGIiMGI:1353455, Mlh3

Phylogenomic databases

GeneTreeiENSGT00800000124176
OrthoDBi735423at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mlh3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiA0A1Y7VMP7, baseline and differential

Family and domain databases

Gene3Di2.30.42.20, 1 hit
3.30.1370.100, 1 hit
3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR014762, DNA_mismatch_repair_CS
IPR013507, DNA_mismatch_S5_2-like
IPR036890, HATPase_C_sf
IPR028830, Mlh3
IPR038973, MutL/Mlh/Pms
IPR014790, MutL_C
IPR042120, MutL_C_dimsub
IPR042121, MutL_C_regsub
IPR037198, MutL_C_sf
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073, PTHR10073, 1 hit
PTHR10073:SF47, PTHR10073:SF47, 1 hit
PfamiView protein in Pfam
PF01119, DNA_mis_repair, 1 hit
PF08676, MutL_C, 1 hit
SMARTiView protein in SMART
SM01340, DNA_mis_repair, 1 hit
SM00853, MutL_C, 1 hit
SUPFAMiSSF118116, SSF118116, 1 hit
SSF54211, SSF54211, 1 hit
SSF55874, SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00058, DNA_MISMATCH_REPAIR_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1Y7VMP7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1Y7VMP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2017
Last sequence update: August 30, 2017
Last modified: June 2, 2021
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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