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Entry version 16 (16 Oct 2019)
Sequence version 1 (30 Aug 2017)
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Protein
Submitted name:

Phosphatidate phosphatase LPIN1

Gene

Lpin1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphatidate phosphatase LPIN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lpin1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891340 Lpin1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini675 – 831LNS2InterPro annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 264DisorderedSequence analysisAdd BLAST132
Regioni281 – 393DisorderedSequence analysisAdd BLAST113
Regioni413 – 457DisorderedSequence analysisAdd BLAST45
Regioni594 – 616DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 264PolarSequence analysisAdd BLAST50
Compositional biasi300 – 329PolarSequence analysisAdd BLAST30
Compositional biasi430 – 457PolarSequence analysisAdd BLAST28

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157219

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSDGEWS

Database of Orthologous Groups

More...
OrthoDBi
866929at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412 HAD-like_sf
IPR026058 LIPIN
IPR031703 Lipin_mid
IPR007651 Lipin_N
IPR013209 LNS2
IPR031315 LNS2/PITP
IPR028794 LPIN1

The PANTHER Classification System

More...
PANTHERi
PTHR12181 PTHR12181, 2 hits
PTHR12181:SF10 PTHR12181:SF10, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16876 Lipin_mid, 1 hit
PF04571 Lipin_N, 1 hit
PF08235 LNS2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00775 LNS2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A1Y7VLN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GSLQCSPFHV
60 70 80 90 100
RFGKMGVLRS REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEIIP
110 120 130 140 150
MYLATSPILS EGAARMESQL KRNSVDRIRC LDPTTAAQGL PPSDTPSTGS
160 170 180 190 200
LGKKRRKRRR KAQLDNLKRD DNVNTSEDED MFPIEMSSDE DTAPMDGSRT
210 220 230 240 250
LPNDVPPFQD DIPKENFPSI STYPQSASYP SSDREWSPSP SPSGSRPSTP
260 270 280 290 300
KSDSELVSKS ADRLTPKNNL EMLWLWGELP QAAKSSSPHK MKESSPLGSR
310 320 330 340 350
KTPDKMNFQA IHSESSDTFS DQSPTMARGL LIHQSKAQTE MQFVNEEDLE
360 370 380 390 400
SLGAAAPPSP VAEELKAPYP NTAQSSSKTD SPSRKKDKRS RHLGADGVYL
410 420 430 440 450
DDLTDMDPEV AALYFPKNGD PGGLPKQASD NGARSANQSP QSVGGSGIDS
460 470 480 490 500
GVESTSDSLR DLPSIAISLC GGLSDHREIT KDAFLEQAVS YQQFADNPAI
510 520 530 540 550
IDDPNLVVKV GNKYYNWTTA APLLLAMQAF QKPLPKATVE SIMRDKMPKK
560 570 580 590 600
GGRWWFSWRG RNATIKEESK PEQCLTGKGH NTGEQPAQLG LATRIKHESS
610 620 630 640 650
SSDEEHAAAK PSGSSHLSLL SNVSYKKTLR LTSEQLKSLK LKNGPNDVVF
660 670 680 690 700
SVTTQYQGTC RCEGTIYLWN WDDKVIISDI DGTITRSDTL GHILPTLGKD
710 720 730 740 750
WTHQGIAKLY HKVSQNGYKF LYCSARAIGM ADMTRGYLHW VNERGTVLPQ
760 770 780 790 800
GPLLLSPSSL FSALHREVIE KKPEKFKVQC LTDIKNLFFP NTEPFYAAFG
810 820 830 840 850
NRPADVYSYK QVGVSLNRIF TVNPKGELVQ EHAKTNISSY VRLCEVVDHV
860 870 880 890
FPLLKRSHSC DFPCSDTFSN FTFWREPLPP FENQDMHSAS A
Length:891
Mass (Da):98,536
Last modified:August 30, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8724C8C2858F4D82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91ZP3LPIN1_MOUSE
Phosphatidate phosphatase LPIN1
Lpin1 Fld
924Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QKQ5E9QKQ5_MOUSE
Phosphatidate phosphatase LPIN1
Lpin1
924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJ01A0A1Y7VJ01_MOUSE
Phosphatidate phosphatase LPIN1
Lpin1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122228 Genomic DNA No translation available.
AC159631 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001123884.1, NM_001130412.1
NP_766538.2, NM_172950.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000221230; ENSMUSP00000152466; ENSMUSG00000020593
ENSMUST00000222989; ENSMUSP00000152276; ENSMUSG00000020593

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14245

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122228 Genomic DNA No translation available.
AC159631 Genomic DNA No translation available.
RefSeqiNP_001123884.1, NM_001130412.1
NP_766538.2, NM_172950.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000221230; ENSMUSP00000152466; ENSMUSG00000020593
ENSMUST00000222989; ENSMUSP00000152276; ENSMUSG00000020593
GeneIDi14245

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23175
MGIiMGI:1891340 Lpin1

Phylogenomic databases

GeneTreeiENSGT00940000157219
OMAiHSDGEWS
OrthoDBi866929at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lpin1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR026058 LIPIN
IPR031703 Lipin_mid
IPR007651 Lipin_N
IPR013209 LNS2
IPR031315 LNS2/PITP
IPR028794 LPIN1
PANTHERiPTHR12181 PTHR12181, 2 hits
PTHR12181:SF10 PTHR12181:SF10, 2 hits
PfamiView protein in Pfam
PF16876 Lipin_mid, 1 hit
PF04571 Lipin_N, 1 hit
PF08235 LNS2, 1 hit
SMARTiView protein in SMART
SM00775 LNS2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1Y7VLN4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1Y7VLN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2017
Last sequence update: August 30, 2017
Last modified: October 16, 2019
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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