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Entry version 34 (02 Jun 2021)
Sequence version 1 (30 Aug 2017)
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Protein

Probable sugar efflux transporter

Gene

sotB

Organism
Klebsiella pneumoniae subsp. pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transportUniRule annotationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable sugar efflux transporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sotBUniRule annotationImported
ORF Names:C4Z38_017695Imported, E3U37_16695Imported, E3U38_21895Imported, EJ893_11515Imported, I5002_14085Imported, JMY88_12580Imported, NCTC9504_03548Imported, RJA_14060Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKlebsiella pneumoniae subsp. pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri72407 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000285583 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000269786 Componenti: Unassembled WGS sequence
  • UP000254020 Componenti: Unassembled WGS sequence
  • UP000297959 Componenti: Unassembled WGS sequence
  • UP000196356 Componenti: Chromosome
  • UP000298346 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei54 – 73HelicalUniRule annotationAdd BLAST20
Transmembranei80 – 99HelicalUniRule annotationAdd BLAST20
Transmembranei105 – 127HelicalUniRule annotationAdd BLAST23
Transmembranei139 – 160HelicalUniRule annotationAdd BLAST22
Transmembranei166 – 189HelicalUniRule annotationAdd BLAST24
Transmembranei210 – 232HelicalUniRule annotationAdd BLAST23
Transmembranei244 – 264HelicalUniRule annotationAdd BLAST21
Transmembranei276 – 295HelicalUniRule annotationAdd BLAST20
Transmembranei301 – 321HelicalUniRule annotationAdd BLAST21
Transmembranei333 – 352HelicalUniRule annotationAdd BLAST20
Transmembranei364 – 384HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membraneUniRule annotationARBA annotation, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 388MFSInterPro annotationAdd BLAST375

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00517, MFS_SotB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR023495, Sugar_effux_transptr_put

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1Y0PYF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTNTVSRKV AWLRVVTLAI AAFIFNTTEF APVGLLSDIA DSFGMETAQV
60 70 80 90 100
GMMLTIYAWV VALMSLPFML LTSKVERRRL LIGLFILFIA SHVLSFFAWN
110 120 130 140 150
FDVLVISRIG IAFAHAVFWS ITSALAIRMA PPGKRAQALS LIATGTALAM
160 170 180 190 200
VFGIPIGRII GQYFGWRMTF LAIGLGALAT LACLVKLLPT LPSEHSGSLK
210 220 230 240 250
SLPVLFRRPA LVSVYILTVV VVTAHYTAYS YIEPFVQTVA GLSGNFATVL
260 270 280 290 300
LLILGGAGII GSILFGKLGN QHASGLISLA IALLLACLLL LLPASHNPQH
310 320 330 340 350
LMLLSIFWGV AIMIIGLGMQ VKVLASAPDA TDVAMSLFSG IFNIGIGAGA
360 370 380 390
LVGSQVSLHL SMASVGYVGA IPALVALVWS LMIFRRWPVS LEDHQPHHS
Length:399
Mass (Da):42,609
Last modified:August 30, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E5073D38B11A3D5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP019047 Genomic DNA Translation: ARV40234.1
CP068689 Genomic DNA Translation: QQZ96199.1
CP068684 Genomic DNA Translation: QRA06640.1
PTHN02000058 Genomic DNA Translation: ROC08877.1
RWYL01000076 Genomic DNA Translation: RTD76874.1
UGMA01000005 Genomic DNA Translation: STU81367.1
SOMK01000072 Genomic DNA Translation: TFB51887.1
SOMI01000050 Genomic DNA Translation: TFB68914.1

NCBI Reference Sequences

More...
RefSeqi
WP_002904407.1, NZ_WNWP01000016.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ARV40234; ARV40234; RJA_14060
STU81367; STU81367; NCTC9504_03548
THH59589; THH59589; E9152_18125
THH73594; THH73594; E9156_05190
THI06246; THI06246; E9171_04340
THI51295; THI51295; E9149_18235
THI89920; THI89920; E9159_01395
THK72319; THK72319; FAM97_09485
THK89123; THK89123; FAM70_03370
THL44080; THL44080; FAM87_15555
THL96337; THL96337; FAN16_10150
THM27105; THM27105; FAN59_09900
THM40219; THM40219; FAN83_00480
THM72959; THM72959; FAP95_12335
THM82083; THM82083; FAO25_05190
THM97563; THM97563; FAO13_01695
THN00051; THN00051; FAO18_01695
THO14101; THO14101; FAR05_10045
THO20103; THO20103; FAR03_15580
THO30360; THO30360; FAR06_11390
THQ82368; THQ82368; FAT64_11340
THR38383; THR38383; FAS48_01945
THS97826; THS97826; FAT94_10690
THT21005; THT21005; FAT86_07610
THT34703; THT34703; FAT84_10170
THU14291; THU14291; FAT98_02055
THU33933; THU33933; FAU02_05410

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
kpg:KPNIH32_13040
kpv:KPNIH29_12900
kpw:KPNIH30_13190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP019047 Genomic DNA Translation: ARV40234.1
CP068689 Genomic DNA Translation: QQZ96199.1
CP068684 Genomic DNA Translation: QRA06640.1
PTHN02000058 Genomic DNA Translation: ROC08877.1
RWYL01000076 Genomic DNA Translation: RTD76874.1
UGMA01000005 Genomic DNA Translation: STU81367.1
SOMK01000072 Genomic DNA Translation: TFB51887.1
SOMI01000050 Genomic DNA Translation: TFB68914.1
RefSeqiWP_002904407.1, NZ_WNWP01000016.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiARV40234; ARV40234; RJA_14060
STU81367; STU81367; NCTC9504_03548
THH59589; THH59589; E9152_18125
THH73594; THH73594; E9156_05190
THI06246; THI06246; E9171_04340
THI51295; THI51295; E9149_18235
THI89920; THI89920; E9159_01395
THK72319; THK72319; FAM97_09485
THK89123; THK89123; FAM70_03370
THL44080; THL44080; FAM87_15555
THL96337; THL96337; FAN16_10150
THM27105; THM27105; FAN59_09900
THM40219; THM40219; FAN83_00480
THM72959; THM72959; FAP95_12335
THM82083; THM82083; FAO25_05190
THM97563; THM97563; FAO13_01695
THN00051; THN00051; FAO18_01695
THO14101; THO14101; FAR05_10045
THO20103; THO20103; FAR03_15580
THO30360; THO30360; FAR06_11390
THQ82368; THQ82368; FAT64_11340
THR38383; THR38383; FAS48_01945
THS97826; THS97826; FAT94_10690
THT21005; THT21005; FAT86_07610
THT34703; THT34703; FAT84_10170
THU14291; THU14291; FAT98_02055
THU33933; THU33933; FAU02_05410
KEGGikpg:KPNIH32_13040
kpv:KPNIH29_12900
kpw:KPNIH30_13190

Family and domain databases

HAMAPiMF_00517, MFS_SotB, 1 hit
InterProiView protein in InterPro
IPR011701, MFS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR023495, Sugar_effux_transptr_put
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1Y0PYF5_KLEPN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1Y0PYF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 30, 2017
Last sequence update: August 30, 2017
Last modified: June 2, 2021
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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