UniProtKB - A0A1X9ZBN4 (A0A1X9ZBN4_9SPHI)
Protein
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Gene
accA
Organism
Sphingobacteriaceae bacterium GW460-11-11-14-LB5
Status
Functioni
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation
Catalytic activityi
- acetyl-CoA + N6-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N6-biotinyl-L-lysyl-[protein]UniRule annotationARBA annotationEC:2.1.3.15UniRule annotationARBA annotation
: malonyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (CA265_18365), Biotin carboxylase (CA265_02215), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- carboxyl- or carbamoyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-UniRule
- malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseUniRule annotationImportedARBA annotation |
Biological process | Fatty acid biosynthesisUniRule annotationARBA annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation)Short name: ACCase subunit alphaUniRule annotation Short name: Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation |
Gene namesi | Name:accAUniRule annotation ORF Names:CA265_24715Imported |
Organismi | Sphingobacteriaceae bacterium GW460-11-11-14-LB5Imported |
Taxonomic identifieri | 1986952 [NCBI] |
Taxonomic lineagei | Bacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Sphingobacteriaceae › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- acetyl-CoA carboxylase complex Source: InterPro
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 295 | CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST | 258 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 14 – 34 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the AccA family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
HAMAPi | MF_00823, AcetylCoA_CT_alpha, 1 hit |
InterProi | View protein in InterPro IPR001095, Acetyl_CoA_COase_a_su IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C |
PANTHERi | PTHR42853, PTHR42853, 1 hit |
Pfami | View protein in Pfam PF03255, ACCA, 1 hit |
PRINTSi | PR01069, ACCCTRFRASEA |
SUPFAMi | SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR00513, accA, 1 hit |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A1X9ZBN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQIKTSFDF EKPIADLVQQ IEKVKQVAEK TKVDMSATLD ELDGKLDETT
60 70 80 90 100
NNLYKNLTGW NKVQMSRHPD RPQTLDYINM ICDDFIEMHG DRTVKDDKAI
110 120 130 140 150
IGGFASINGQ TVMVIGHQKG KNTKERQFRN FGMANPEGYR KALRLMRLAE
160 170 180 190 200
KFNKPVVSFI DTMGAYPGLE AEERGQGEAI ARNLLEMSIL RVPIICIVVG
210 220 230 240 250
EGASGGALGI GIGDKVYMLE HTWYSVISPE SCSSILWRSW DFKEKAAECL
260 270 280 290 300
KLTSDDMFGN KLIDGIIPEP LGGAHQDPEL MGRTLKDYLV KDLAALGKLK
310 320
TDKLIEQRIE KFCAMGVVNE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP021237 Genomic DNA Translation: ARS42690.1 |
Genome annotation databases
KEGGi | sbx:CA265_24715 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP021237 Genomic DNA Translation: ARS42690.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
KEGGi | sbx:CA265_24715 |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Family and domain databases
HAMAPi | MF_00823, AcetylCoA_CT_alpha, 1 hit |
InterProi | View protein in InterPro IPR001095, Acetyl_CoA_COase_a_su IPR029045, ClpP/crotonase-like_dom_sf IPR011763, COA_CT_C |
PANTHERi | PTHR42853, PTHR42853, 1 hit |
Pfami | View protein in Pfam PF03255, ACCA, 1 hit |
PRINTSi | PR01069, ACCCTRFRASEA |
SUPFAMi | SSF52096, SSF52096, 1 hit |
TIGRFAMsi | TIGR00513, accA, 1 hit |
PROSITEi | View protein in PROSITE PS50989, COA_CT_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1X9ZBN4_9SPHI | |
Accessioni | A0A1X9ZBN4Primary (citable) accession number: A0A1X9ZBN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 30, 2017 |
Last sequence update: | August 30, 2017 | |
Last modified: | December 2, 2020 | |
This is version 16 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |