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UniProtKB - A0A1X7SBS6 (A0A1X7SBS6_HUMAN)
Protein
Submitted name:
Potassium voltage-gated channel subfamily H member 1
Gene
KCNH1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- voltage-gated potassium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation, Ion channel, Potassium channelARBA annotation, Voltage-gated channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Names & Taxonomyi
Protein namesi | Submitted name: Potassium voltage-gated channel subfamily H member 1Imported |
Gene namesi | Name:KCNH1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6250, KCNH1 |
VEuPathDBi | HostDB:ENSG00000143473 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 220 – 239 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 349 – 373 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 422 – 439 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 451 – 475 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A1X7SBS6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 94 | PASInterPro annotationAdd BLAST | 81 | |
Domaini | 93 – 145 | PACInterPro annotationAdd BLAST | 53 | |
Domaini | 554 – 654 | Cyclic nucleotide-bindingInterPro annotationAdd BLAST | 101 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 835 – 859 | DisorderedSequence analysisAdd BLAST | 25 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155793 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR030170, EAG1 IPR005821, Ion_trans_dom IPR003949, K_chnl_volt-dep_EAG IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR001610, PAC IPR000014, PAS IPR000700, PAS-assoc_C IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR10217:SF530, PTHR10217:SF530, 2 hits |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01464, EAGCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00086, PAC, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50113, PAC, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A1X7SBS6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMAGGRRGL VAPQNTFLEN IVRRSNDTNF VLGNAQIVDW PIVYSNDGFC
60 70 80 90 100
KLSGYHRAEV MQKSSTCSFM YGELTDKDTI EKVRQTFENY EMNSFEILMY
110 120 130 140 150
KKNRTPVWFF VKIAPIRNEQ DKVVLFLCTF SDITAFKQPI EDDSCKGWGK
160 170 180 190 200
FARLTRALTS SRGVLQQLAP SVQKGENVHK HSRLAEVLQL GSDILPQYKQ
210 220 230 240 250
EAPKTPPHII LHYCVFKTTW DWIILILTFY TAILVPYNVS FKTRQNNVAW
260 270 280 290 300
LVVDSIVDVI FLVDIVLNFH TTFVGPAGEV ISDPKLIRMN YLKTWFVIDL
310 320 330 340 350
LSCLPYDVIN AFENVDEGIS SLFSSLKVVR LLRLGRVARK LDHYIEYGAA
360 370 380 390 400
VLVLLVCVFG LAAHWMACIW YSIGDYEIFD EDTKTIRNNS WLYQLAMDIG
410 420 430 440 450
TPYQFNGSGS GKWEGGPSKN SVYISSLYFT MTSLTSVGFG NIAPSTDIEK
460 470 480 490 500
IFAVAIMMIG SLLYATIFGN VTTIFQQMYA NTNRYHEMLN SVRDFLKLYQ
510 520 530 540 550
VPKGLSERVM DYIVSTWSMS RGIDTEKVLQ ICPKDMRADI CVHLNRKVFK
560 570 580 590 600
EHPAFRLASD GCLRALAMEF QTVHCAPGDL IYHAGESVDS LCFVVSGSLE
610 620 630 640 650
VIQDDEVVAI LGKGDVFGDV FWKEATLAQS CANVRALTYC DLHVIKRDAL
660 670 680 690 700
QKVLEFYTAF SHSFSRNLIL TYNLRKRIVF RKISDVKREE EERMKRKNEA
710 720 730 740 750
PLILPPDHPV RRLFQRFRQQ KEARLAAERG GRDLDDLDVE KGNVLTEHAS
760 770 780 790 800
ANHSLVKASV VTVRESPATP VSFQAASTSG VPDHAKLQAP GSECLGPKGG
810 820 830 840 850
GGDCAKRKSW ARFKDACGKS EDWNKVSKAE SMETLPERTK ASGEATLKKT
860 870 880 890 900
DSCDSGITKS DLRLDNVGEA RSPQDRSPIL AEVKHSFYPI PEQTLQATVL
910
EGLTLLPRLV SNS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO95259 | KCNH1_HUMAN | Potassium voltage-gated channel sub... | KCNH1 EAG, EAG1 | 989 | Annotation score: | ||
A0A1W2PPA2 | A0A1W2PPA2_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 605 | Annotation score: | ||
A0A0S1TJ81 | A0A0S1TJ81_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 454 | Annotation score: | ||
A0A1W2PNI2 | A0A1W2PNI2_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 940 | Annotation score: | ||
A0A1W2PP68 | A0A1W2PP68_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 354 | Annotation score: | ||
A0A1W2PRV9 | A0A1W2PRV9_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 327 | Annotation score: | ||
A0A1W2PRD8 | A0A1W2PRD8_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 208 | Annotation score: | ||
A0A1W2PRZ5 | A0A1W2PRZ5_HUMAN | Potassium voltage-gated channel sub... | KCNH1 | 427 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092017 Genomic DNA No translation available. AC096636 Genomic DNA No translation available. AC099755 Genomic DNA No translation available. AC217414 Genomic DNA No translation available. AL590132 Genomic DNA No translation available. AL603791 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000367007; ENSP00000355974; ENSG00000143473 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092017 Genomic DNA No translation available. AC096636 Genomic DNA No translation available. AC099755 Genomic DNA No translation available. AC217414 Genomic DNA No translation available. AL590132 Genomic DNA No translation available. AL603791 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A1X7SBS6 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1X7SBS6 |
Protocols and materials databases
Antibodypediai | 20707, 229 antibodies from 28 providers |
Genome annotation databases
Ensembli | ENST00000367007; ENSP00000355974; ENSG00000143473 |
Organism-specific databases
HGNCi | HGNC:6250, KCNH1 |
OpenTargetsi | ENSG00000143473 |
VEuPathDBi | HostDB:ENSG00000143473 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155793 |
Miscellaneous databases
ChiTaRSi | KCNH1, human |
Gene expression databases
ExpressionAtlasi | A0A1X7SBS6, baseline and differential |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR030170, EAG1 IPR005821, Ion_trans_dom IPR003949, K_chnl_volt-dep_EAG IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR001610, PAC IPR000014, PAS IPR000700, PAS-assoc_C IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
PANTHERi | PTHR10217:SF530, PTHR10217:SF530, 2 hits |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01464, EAGCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00086, PAC, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50113, PAC, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1X7SBS6_HUMAN | |
Accessioni | A0A1X7SBS6Primary (citable) accession number: A0A1X7SBS6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2017 |
Last sequence update: | July 5, 2017 | |
Last modified: | January 19, 2022 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |