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Protein

Octanoyltransferase LipM

Gene

lipM

Organism
Staphylococcus sciuri
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.UniRule annotation

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. The reaction proceeds via an octanoyl-thioester enzyme intermediate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Octanoyl-[acyl-carrier-protein] + protein = protein N6-(octanoyl)lysine + [acyl-carrier-protein].UniRule annotation

Pathwayi: protein lipoylation via endogenous pathway

This protein is involved in the subpathway that synthesizes protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].UniRule annotation This subpathway is part of the pathway protein lipoylation via endogenous pathway, which is itself part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein lipoylation via endogenous pathway and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149Acyl-thioester intermediateUniRule annotation1
Sitei164Lowers pKa of active site CysUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Octanoyltransferase LipMUniRule annotation (EC:2.3.1.181UniRule annotation)
Alternative name(s):
Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferaseUniRule annotation
Gene namesi
Name:lipMUniRule annotation
ORF Names:B5723_07430Imported
OrganismiStaphylococcus sciuriImported
Taxonomic identifieri1296 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000192630 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 247BPL/LPL catalyticInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili250 – 270Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the octanoyltransferase LipM family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

HAMAPiMF_02118 LipM, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024898 LipM
PANTHERiPTHR43679:SF3 PTHR43679:SF3, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1X0TUB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKETWHFLNT KSNNPYYNMA VDEALMNFVS RGEIDPVIRF YTWDPATLSI
60 70 80 90 100
GYFQKLTKEI DIEKVKEKGF GLVRRATGGR GVLHDKELTY SVIVPESYPN
110 120 130 140 150
MPKTVTEAYR VISEGLLEGF KSLGFDAYFS IPKTKEERDK LKTPRSSVCF
160 170 180 190 200
DAPSWYELVV EDRKIAGSAQ TRQKGVILQH GSILQDIDVD ELFDMFIYRN
210 220 230 240 250
DRLKDKMKAA FTNKAVAIND LSDKFITLEE METAFYEGFK KGLDIVYKPL
260 270
EFTEEQLAEI KQLEEKYKSE DWTYRK
Length:276
Mass (Da):32,068
Last modified:July 5, 2017 - v1
Checksum:i58E5B7A50C57252B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NADO01000002 Genomic DNA Translation: ORI03830.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NADO01000002 Genomic DNA Translation: ORI03830.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_02118 LipM, 1 hit
InterProiView protein in InterPro
IPR004143 BPL_LPL_catalytic
IPR024898 LipM
PANTHERiPTHR43679:SF3 PTHR43679:SF3, 1 hit
PfamiView protein in Pfam
PF03099 BPL_LplA_LipB, 1 hit
PROSITEiView protein in PROSITE
PS51733 BPL_LPL_CATALYTIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1X0TUB9_STASC
AccessioniPrimary (citable) accession number: A0A1X0TUB9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: April 25, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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