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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Mycobacterium parafortuitum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
ORF Names:BST38_13175Imported
OrganismiMycobacterium parafortuitumImported
Taxonomic identifieri39692 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium
Proteomesi
  • UP000192827 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei703N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1X0HTK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKSQSPSV PQFVDRHIGP DPAAVDTLLN TIGVSSLDEL AAKALPAGIL
60 70 80 90 100
DPLSADGVAP GLEHLPPAAS EHEALAELRA LADSNTVAVS MIGQGYYDTL
110 120 130 140 150
TPPVLRRNIL ENPAWYTAYT PYQPEISQGR LEALLNFQTV VTDLTGLEVA
160 170 180 190 200
NASMLDEGTA AAEAMTLMHR AVRGPANTLA VDIDIYPQTA AILATRAEPL
210 220 230 240 250
GIEIVTADLR DGLPDGEFFG AIVQSPGASG RITDWTALVG QAHERGALVA
260 270 280 290 300
VGADLLAATL ITPPGEIGAD VAFGTTQRFG VPMGFGGPHA GYLAVHSKHA
310 320 330 340 350
RQLPGRLVGV SVDADGSPAY RLALQTREQH IRRDKATSNI CTAQVLLAVM
360 370 380 390 400
AAMYASYHGP DGLRAIAQRV HDKARAIAAG LAGAGVEVVH DRFFDTVLAR
410 420 430 440 450
VPGRAEQVRA AAKERGINVW VADVDHVSVA CDEATTDAIV ADVLAAFGAT
460 470 480 490 500
PAAGDFAGPA IQNRTSEFLT HPAFSKYRTE TSMMRYLRAL ADKDIALDRS
510 520 530 540 550
MIPLGSCTMK LNAAAEMEAI TWSEFARQHP FAPASDTPGL RRLIADLQSW
560 570 580 590 600
LTGITGYDEI SLQPNAGSQG EYAGLLAIQA YHNERGDTGR TVCLIPSSAH
610 620 630 640 650
GTNAASAAMV GMKVVVVACR ANGDVDLDDL RAKVAEHADR LSALMITYPS
660 670 680 690 700
THGVYEHDVA EICAAVHDAG GQVYVDGANL NALVGLARPG RFGGDVSHLN
710 720 730 740 750
LHKTFCIPHG GGGPGVGPVA VRAHLAPYLP GHPLAAELSD RHTVSAAPYG
760 770 780 790 800
SASILPITWA YIRMMGAAGL RSATLVAIAS ANYIARRLDE YYPVLYTGEN
810 820 830 840 850
GMVAHECILD LRGITKATGV TVDDVAKRLA DYGFHAPTMS FPVAGTLMVE
860 870 880 890 900
PTESESLAEI DAFCDAMIAI RAEIDKVGSG EWPVDDNPLR GAPHTAESLL
910 920 930 940 950
IDEWAHPYTR EQAAYPLGKG FRPKVWPPVR RIDGAYGDRN LVCSCPPVEA

FA
Length:952
Mass (Da):100,634
Last modified:July 5, 2017 - v1
Checksum:iD2D973788D2EB54C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MVID01000010 Genomic DNA Translation: ORB29785.1

Similar proteinsi

Entry informationi

Entry nameiA0A1X0HTK3_MYCPF
AccessioniPrimary (citable) accession number: A0A1X0HTK3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: June 20, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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