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Protein

Alanine racemase

Gene

B7492_12645

Organism
Bacillus mycoides
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (BWINRASL_01926), Alanine racemase (BWINRASL_00237), Alanine racemase (BTH41_03616), Alanine racemase (BWGOE11_21800), Alanine racemase (bcere0026_2190), Alanine racemase (AWW70_10470), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (BW900_21375), Alanine racemase (B7492_11275), Alanine racemase (BWGOE11_03250), Alanine racemase (S3E15_01890), Alanine racemase (BTJ45_01846), Alanine racemase (BW664_02081), Alanine racemase (alr2), Alanine racemase (COL41_07040), Alanine racemase (alr), Alanine racemase (BLX04_21345), Alanine racemase (bcere0007_2170), Alanine racemase (BTJ45_01173), Alanine racemase (bcere0026_18830), Alanine racemase (bcere0007_21440), Alanine racemase (alr), Alanine racemase (B7492_01365), Alanine racemase (alr), Alanine racemase (bcere0007_19400), Alanine racemase (alr), Alanine racemase (BTH41_02681), Alanine racemase (BWINRA5_00372), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (BWGOE8_02420), Alanine racemase (alr1), Alanine racemase (AWW70_23770), Alanine racemase (BWGO95_01965), Alanine racemase (B7492_12645), Alanine racemase (BW664_00250), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (BWGOE8_57430), Alanine racemase (alr), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei268Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei316Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:B7492_12645Imported
OrganismiBacillus mycoidesImported
Taxonomic identifieri1405 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000192932 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 375Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1W6A851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVNYGRHTI IEVDLNALQR NFQQYKQAIP FGTAIMTVVK ANAYGHGAVP
60 70 80 90 100
IAKAVIEAGT SHLAVAFVDE GIELREAGIT VPILIFGYTP YEAIVDAITY
110 120 130 140 150
DLSMTVYTIE DLHAIEEVAS QMEKNAYIHI KIDTGMSRLG LQLNEVTLFL
160 170 180 190 200
QTLKCTKYIQ VEGMYTHFAC ADERDKMYTL MQQEVFQKAV SKAEELQIVI
210 220 230 240 250
PWIHANNSAA TIDMRETKGN MVRLGIALYG LYPSADVNQE AIWLQPILTF
260 270 280 290 300
KSKVAHIKKV KKGNGVSYGA TYTATGEEWI ATIPVGYADG VSRQLSNKGF
310 320 330 340 350
VLIKGMKVPI IGRICMDQLM LDVTKIMPIH VGDEVVFYGN QGEESISVDC
360 370 380 390
VADILSTINY EITCMLSRRI PRIYIKDNKP IEIINELRRS PISLCINE
Length:398
Mass (Da):44,425
Last modified:July 5, 2017 - v1
Checksum:iE490572AD4AEC0D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP020743 Genomic DNA Translation: ARJ22033.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP020743 Genomic DNA Translation: ARJ22033.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1W6A851_BACMY
AccessioniPrimary (citable) accession number: A0A1W6A851
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2017
Last sequence update: July 5, 2017
Last modified: October 10, 2018
This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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