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Protein
Submitted name:

muscle, skeletal receptor tyrosine-protein kinase isoform X2

Gene

musk

Organism
Scleropages formosus (Asian bonytongue)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
muscle, skeletal receptor tyrosine-protein kinase isoform X2Imported
Gene namesi
Name:muskImported
OrganismiScleropages formosus (Asian bonytongue)Imported
Taxonomic identifieri113540 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOsteoglossocephalaOsteoglossomorphaOsteoglossiformesOsteoglossidaeScleropages
Proteomesi
  • UP000192224 Componenti: Genome assembly

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei567 – 593HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501073098224 – 944Sequence analysisAdd BLAST921

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 104Ig-likeInterPro annotationAdd BLAST77
Domaini121 – 201Ig-likeInterPro annotationAdd BLAST81
Domaini203 – 302Ig-likeInterPro annotationAdd BLAST100
Domaini311 – 449FZInterPro annotationAdd BLAST139
Domaini462 – 541KringleInterPro annotationAdd BLAST80
Domaini650 – 931Protein kinaseInterPro annotationAdd BLAST282

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, KringlePROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00130 KR, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 3 hits
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A1W5A063-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLPHILLA LAFLPATLRP IAGQQKAPRI TTLLETVDVL LDHNATFICE
60 70 80 90 100
VDSRPPADIT WTRNNVQIRT SETHYHTREN GQLLVIVNVR DSDNGEYCCT
110 120 130 140 150
ADNGIGEPAK SCGALQLKMR PQIKRHPSNV TLLIESKAVL PCVTLGNPKP
160 170 180 190 200
DISWIKDDEL VKVSDHITIL DYGALKIHSI KKEDAGQYRC VARNSLGTAY
210 220 230 240 250
SKPATIEVQA PARILKVPKE KRVPFGTEVT MECNATGNPV PTITWLENGN
260 270 280 290 300
AISGASVEDT IVGEVVLSVL RVVVNKPALY TCLATNRPSG GANTMKATAK
310 320 330 340 350
VTVSEWRLYK GNAGYCGTYR GEMCRGALRA DALLFFNTSL GDPEDTQELI
360 370 380 390 400
VQSSWAGLER VSTLCRQAAR ALICHHAFQD CNPSDLGPVP KPVCREHCLA
410 420 430 440 450
VRDFYCDKEW LSMEDSSHRG IYSSRTGITL PDCTHLPNQK TDDSACTAIS
460 470 480 490 500
YIDIKKDQVT TKCYNDRGQF YLGTANVTAS GVPCQKWSQQ SPHTHRLSPG
510 520 530 540 550
IIPELRNAEN YCRNPGAEKE RPWCFTTSPL LRWEYCNVPK CGEVMVPAST
560 570 580 590 600
YPRQLTPNLP PSVSPTYSMS VIIFVMAGVA AAAFLTILAL MCCKRKKLWK
610 620 630 640 650
SRKRVMETPA LTALPSELLL DRLHPNPMYQ RLPLLLNSKL LSLEYPRNNI
660 670 680 690 700
EYVRDIGEGA FGRVFQARAP GLLPMEPFTM VAVKMLKEEA SADMQNDFQR
710 720 730 740 750
EAALMAEFDH PNIVKLLGVC AVGKPMCLMF EYMAHGDLNE FLRRRSPNLQ
760 770 780 790 800
ASLSRTSLSG RSFSSELEAS PLTCLEQLYI SKQVAAGMAY LSERKFVHRD
810 820 830 840 850
LATRNCLVGG DLVVKIADFG LSRNIYSADY YKANENDAIP IRWMPPESIF
860 870 880 890 900
YNRYTTESDV WAYGVVLWEI FSHGMQPYYG MAHEEVIYYV RDGNILSCPE
910 920 930 940
GCPLELYNLM RLCWSGHPTD RPSFVSIHRI LERMHSQMLH ASLP
Length:944
Mass (Da):105,468
Last modified:June 7, 2017 - v1
Checksum:iE2DFFC4D0A8E00FA
GO

Sequence databases

RefSeqiXP_018606563.1, XM_018751047.1

Genome annotation databases

GeneIDi108933754

Similar proteinsi

Cross-referencesi

Sequence databases

RefSeqiXP_018606563.1, XM_018751047.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi108933754

Organism-specific databases

CTDi4593

Family and domain databases

CDDicd00108 KR, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.20.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF07679 I-set, 1 hit
PF00051 Kringle, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00130 KR, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50835 IG_LIKE, 3 hits
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A1W5A063_9TELE
AccessioniPrimary (citable) accession number: A0A1W5A063
Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: September 12, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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