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Entry version 21 (02 Jun 2021)
Sequence version 1 (07 Jun 2017)
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Protein

Sodium channel protein

Gene

LOC108097930

Organism
Drosophila ficusphila (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC108097930Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila ficusphila (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30025 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000192221 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei144 – 171HelicalUniRule annotationAdd BLAST28
Transmembranei215 – 237HelicalUniRule annotationAdd BLAST23
Transmembranei249 – 267HelicalUniRule annotationAdd BLAST19
Transmembranei273 – 295HelicalUniRule annotationAdd BLAST23
Transmembranei405 – 427HelicalUniRule annotationAdd BLAST23
Transmembranei810 – 833HelicalUniRule annotationAdd BLAST24
Transmembranei854 – 871HelicalUniRule annotationAdd BLAST18
Transmembranei883 – 907HelicalUniRule annotationAdd BLAST25
Transmembranei938 – 960HelicalUniRule annotationAdd BLAST23
Transmembranei980 – 997HelicalUniRule annotationAdd BLAST18
Transmembranei1018 – 1039HelicalUniRule annotationAdd BLAST22
Transmembranei1316 – 1334HelicalUniRule annotationAdd BLAST19
Transmembranei1355 – 1377HelicalUniRule annotationAdd BLAST23
Transmembranei1383 – 1409HelicalUniRule annotationAdd BLAST27
Transmembranei1430 – 1461HelicalUniRule annotationAdd BLAST32
Transmembranei1548 – 1574HelicalUniRule annotationAdd BLAST27
Transmembranei1637 – 1655HelicalUniRule annotationAdd BLAST19
Transmembranei1667 – 1686HelicalUniRule annotationAdd BLAST20
Transmembranei1698 – 1717HelicalUniRule annotationAdd BLAST20
Transmembranei1761 – 1784HelicalUniRule annotationAdd BLAST24
Transmembranei1847 – 1870HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1891 – 1926EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 83DisorderedSequence analysisAdd BLAST56
Regioni552 – 571DisorderedSequence analysisAdd BLAST20
Regioni670 – 690DisorderedSequence analysisAdd BLAST21
Regioni1196 – 1254DisorderedSequence analysisAdd BLAST59
Regioni2014 – 2102DisorderedSequence analysisAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili431 – 481Sequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 64Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi552 – 570Polar residuesSequence analysisAdd BLAST19
Compositional biasi1210 – 1239Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1240 – 1254Acidic residuesSequence analysisAdd BLAST15
Compositional biasi2074 – 2090Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1W4VVN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEP
60 70 80 90 100
QYGRKKKQKE IRYDDEDEDE GPQPDPTLEQ GVPIPVRLQG SFPPELASTP
110 120 130 140 150
LEDIDPYYSN VLTFVVVSKG KDIFRFSASK AMWLLDPFNP IRRVAIYILV
160 170 180 190 200
HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF ESAVKVMARG
210 220 230 240 250
FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
260 270 280 290 300
AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
310 320 330 340 350
IKKFPLDGSW GNLTDENWDY HNRNSSNWYS EDEGISFPLC GNISGAGQCD
360 370 380 390 400
DDYVCLQGFG PNPNYGYTSF DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA
410 420 430 440 450
GPWHMLFFIV IIFLGSFYLV NLILAIVAMS YDELQKKAEE EEAAEEEAIR
460 470 480 490 500
EAEEAAAAKA AKLEERANAQ AQAAADAAAA EEAALHPEMA KSPTYSCISY
510 520 530 540 550
ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAHQATKVRK
560 570 580 590 600
VSTTSLSLPG SPFNIRRGSR SSHKYTIRNG RGRFGIPGSD RKPLVLSTYQ
610 620 630 640 650
DAQQHLPYAD DSNAVTPMSE ENGAIIVPVY YGNLGSRHSS YTSHQSRISY
660 670 680 690 700
TSHGDLLGGM AVMGVSTMTK ESKLRNRNTR NQSVGATNGG TTCLDTNHKL
710 720 730 740 750
EHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ TQTVVDMKDV MVLNDIIEQA
760 770 780 790 800
AGRHSRASDR GVSVYYFPTE DDDEDGPTFK DKALEVILKG IDVFCVWDCC
810 820 830 840 850
WVWLKFQEWV SLIVFDPFVE LFITLCIVVN TMFMAMDHHD MNKEMERVLK
860 870 880 890 900
SGNYFFTATF AIEATMKLMA MSPKYYFQEG WNIFDFIIVA LSLLELGLEG
910 920 930 940 950
VQGLSVLRSF RLLRVFKLAK SWPTLNLLIS IMGRTMGALG NLTFVLCIII
960 970 980 990 1000
FIFAVMGMQL FGKNYHDHKD RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW
1010 1020 1030 1040 1050
IESMWDCMYV GDVSCIPFFL ATVVIGNLVV LNLFLALLLS NFGSSSLSAP
1060 1070 1080 1090 1100
TADNDTNKIA EAFNRIGRFK SWVKRNIADC FKLIRNKLTN QISDQPSGER
1110 1120 1130 1140 1150
TNQISWIWSE EHGDNELELG HDEILADGLI KKGIKEQTQL EVAIGDGMEF
1160 1170 1180 1190 1200
TIHGDMKNNK PKKSKYLNNA TMIGNSINHQ DNRLEHELNH RGLSLQDDDT
1210 1220 1230 1240 1250
ASINSYGSHK NRPFKDESHK GSAETMEGEE KRDASKEDLG LDEELDEEGE
1260 1270 1280 1290 1300
CEEGPLDGDI IIHAHDEDIL DEYPADCCPD SYYKKFPILA GDDDSPFWQG
1310 1320 1330 1340 1350
WGNLRLKTFQ LIENKYFETA VITMILMSSL ALALEDVHLP QRPILQDILY
1360 1370 1380 1390 1400
YMDRIFTVIF FLEMLIKWLA LGFKVYFTNA WCWLDFVIVM VSLINFVASL
1410 1420 1430 1440 1450
VGAGGIQAFK TMRTLRALRP LRAMSRMQGM RVVVNALVQA IPSIFNVLLV
1460 1470 1480 1490 1500
CLIFWLIFAI MGVQLFAGKY FKCEDMNGTK LSHEIIPNRN ACESENYTWV
1510 1520 1530 1540 1550
NSAMNFDHVG NAYLCLFQVA TFKGWIQIMN DAIDSREVDK QPIRETNIYM
1560 1570 1580 1590 1600
YLYFVFFIIF GSFFTLNLFI GVIIDNFNEQ KKKAGGSLEM FMTEDQKKYY
1610 1620 1630 1640 1650
NAMKKMGSKK PLKAIPRPRW RPQAIVFEIV TDKKFDIIIM LFIGLNMFTM
1660 1670 1680 1690 1700
TLDRYDASDT YNAVLDYLNA IFVVIFSSEC LLKIFALRYH YFIEPWNLFD
1710 1720 1730 1740 1750
VVVVILSILG LVLSDIIEKY FVSPTLLRVV RVAKVGRVLR LVKGAKGIRT
1760 1770 1780 1790 1800
LLFALAMSLP ALFNICLLLF LVMFIFAIFG MSFFMHVKEK SGINDVYNFK
1810 1820 1830 1840 1850
TFGQSMILLF QMSTSAGWDG VLDAIINEEA CDPPDNDKGY PGNCGSATVG
1860 1870 1880 1890 1900
ITFLLSYLVI SFLIVINMYI AVILENYSQA TEDVQEGLTD DDYDMYYEIW
1910 1920 1930 1940 1950
QQFDPEGTQY IRYDQLSEFL DVLEPPLQIH KPNKYKIISM DIPICRGDLM
1960 1970 1980 1990 2000
YCVDILDALT KDFFARKGNP IEETGEIGEI AARPDTEGYE PVSSTLWRQR
2010 2020 2030 2040 2050
EEYCARLIQH AWRKHKARGS GGDGGGSFEP DPEQGDHQGG GGNGGEPEAG
2060 2070 2080 2090 2100
APAPGDAADG EAPTDGEAHP AVNGNGTGNG NVNVNMNGNG TGDGAAGADE
2110 2120 2130 2140 2150
SNVNSPIEDA VAAAAAAAVA TAAGAVTTTT TAAGSPGAGS AGRQTAVLVE
2160 2170
SDGFVTKNGH KVVIHSRSPS ITSRTADV
Length:2,178
Mass (Da):244,232
Last modified:June 7, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C4147D24D86DCD2
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_017055977.1, XM_017200488.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108097930

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_017055977.1, XM_017200488.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi108097930

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1W4VVN8_DROFC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1W4VVN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2017
Last sequence update: June 7, 2017
Last modified: June 2, 2021
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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