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UniProtKB - A0A1W2PRT3 (A0A1W2PRT3_HUMAN)
Protein
Glial fibrillary acidic protein
Gene
GFAP
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Glial fibrillary acidic proteinARBA annotation |
Gene namesi | Name:GFAP |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4235, GFAP |
VEuPathDBi | HostDB:ENSG00000131095 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
- intermediate filament cytoskeleton Source: HPA
Keywords - Cellular componenti
Intermediate filamentUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 262 | IF rodInterPro annotationAdd BLAST | 262 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 5 – 106 | Sequence analysisAdd BLAST | 102 | |
Coiled coili | 160 – 233 | Sequence analysisAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the intermediate filament family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000159539 |
Family and domain databases
InterProi | View protein in InterPro IPR027701, GFAP IPR018039, IF_conserved IPR039008, IF_rod_dom |
PANTHERi | PTHR45652:SF9, PTHR45652:SF9, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
A0A1W2PRT3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
YQAELRELRL RLDQLTANSA RLEVERDNLA QDLATVRQKL QDETNLRLEA
60 70 80 90 100
ENNLAAYRQE ADEATLARLD LERKIESLEE EIRFLRKIHE EEVRELQEQL
110 120 130 140 150
ARQQVHVELD VAKPDLTAAL KEIRTQYEAM ASSNMHEAEE WYRSKFADLT
160 170 180 190 200
DAAARNAELL RQAKHEANDY RRQLQSLTCD LESLRGTNES LERQMREQEE
210 220 230 240 250
RHVREAASYQ EALARLEEEG QSLKDEMARH LQEYQDLLNV KLALDIEIAT
260 270 280 290 300
YRKLLEGEEN RITIPVQTFS NLQIRETSLD TKSVSEGHLK RNIVVKTVEM
310 320
RDGEAAPASE PLGLLLLNPS KPLPHV
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP14136 | GFAP_HUMAN | Glial fibrillary acidic protein | GFAP | 432 | Annotation score: | ||
A0A1W2PR46 | A0A1W2PR46_HUMAN | Glial fibrillary acidic protein | GFAP | 505 | Annotation score: | ||
A0A1X7SBR3 | A0A1X7SBR3_HUMAN | Glial fibrillary acidic protein | GFAP | 472 | Annotation score: | ||
K7EJU1 | K7EJU1_HUMAN | Glial fibrillary acidic protein | GFAP | 248 | Annotation score: | ||
A0A1X7SCE1 | A0A1X7SCE1_HUMAN | Glial fibrillary acidic protein | GFAP | 334 | Annotation score: | ||
K7EPI4 | K7EPI4_HUMAN | Glial fibrillary acidic protein | GFAP | 124 | Annotation score: | ||
A0A1W2PPA3 | A0A1W2PPA3_HUMAN | Glial fibrillary acidic protein | GFAP | 69 | Annotation score: | ||
K7EKH9 | K7EKH9_HUMAN | Glial fibrillary acidic protein | GFAP | 261 | Annotation score: | ||
K7ELP4 | K7ELP4_HUMAN | Glial fibrillary acidic protein | GFAP | 189 | Annotation score: | ||
B4DIR1 | B4DIR1_HUMAN | Glial fibrillary acidic protein | GFAP | 179 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015936 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000638618.1; ENSP00000492832.1; ENSG00000131095.14 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC015936 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A1W2PRT3 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A1W2PRT3 |
Protocols and materials databases
Antibodypediai | 3505, 3004 antibodies from 60 providers |
Genome annotation databases
Ensembli | ENST00000638618.1; ENSP00000492832.1; ENSG00000131095.14 |
Organism-specific databases
HGNCi | HGNC:4235, GFAP |
OpenTargetsi | ENSG00000131095 |
VEuPathDBi | HostDB:ENSG00000131095 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000159539 |
Miscellaneous databases
ChiTaRSi | GFAP, human |
Gene expression databases
ExpressionAtlasi | A0A1W2PRT3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR027701, GFAP IPR018039, IF_conserved IPR039008, IF_rod_dom |
PANTHERi | PTHR45652:SF9, PTHR45652:SF9, 1 hit |
Pfami | View protein in Pfam PF00038, Filament, 1 hit |
SMARTi | View protein in SMART SM01391, Filament, 1 hit |
PROSITEi | View protein in PROSITE PS00226, IF_ROD_1, 1 hit PS51842, IF_ROD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A1W2PRT3_HUMAN | |
Accessioni | A0A1W2PRT3Primary (citable) accession number: A0A1W2PRT3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 7, 2017 |
Last sequence update: | June 7, 2017 | |
Last modified: | May 25, 2022 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |